1. G.Patton

    Trimeperidine (Promedol) synthesis

    Introduction The silylation of (1) by a mixture of trimethylchlorosilane and NaI in the presence of Et3N in MeCN leads to the formation of 2-trimethylsilyloxy-3-methyl-1,3-butadiene (2) in an 82.3% yield. By carrying out the reaction in a MeCN solution with addition of NaI, it is possible to...