2-(2-chlorophenyl)-2-nitrocyclohexanone can be converted to ketamine

[dd^YrVmgVfy#8nL4GN^J]

2-(2-chlorophenyl)-2-nitrocyclohexanone can be converted to ketamine. I have seen vendors offering it.

"We found that 2-CPNCH was used as the precursor. Using zinc powder and formic acid, 2-CPNCH was reduced to norketamine. Through the Eschweiler–Clarke reaction, norketamine was reacted with formaldehyde and formic acid to synthesize ketamine; the advantages of this process are a short duration of reaction and the requirement of small amounts of chemicals."

but I havent seen noone talking about this. Seems pretty straight forward.

@G.Patton or @William Dampier , Do you know anything about this reaction?

Perhaps I am wrong, but I wonder if formamide + formic acid could be used, instead of formadelhyde + formic acid

 

[Lokitaste]

What are the approximate costs for the syntesis for 1 kg?
I'm asking because I've looked around at the Chinese sellers and the reagents seem too expensive to me.
Because locally I can get 1kg ketamine for 6700 USD.

 

[Dopey]

zn, formic acid and formaldehyde shouldn't be more than 1k for a kg (excluding the nitro precursor) .I have found a seller on alibaba selling the nitro precursor for 500gr / 900USD. but if the price is 6.7usd/gr, i would say forget it. unless you want to work in really large scale which requires importing tens or hundreds of kilos of that precursor from china. in the country I live, the price of clean racemic k is around 50-40 USD/gr, and still I wouldn't do it.
and even if i was, I wouldn't choose this route. this route has low yields and produces a tertiary amine impurity.

 

[G.Patton]

Hello, I know that it's possible but I haven't seen synthesis write-up data. So far as formamide + formic acid concerned, formamide wont work as formic acid and protonate oxygen of nitro group.

 

[hider8028]

what is it cas?

 

[firskycindy]

It is cas 2079878-75-2

 

[hider8028]

boss, can you provide technology?

 

[DIRECTLABEXPRESS]

Yes its possible, we have done this exact synth. Yeilds not very impressive. I suggest using sodium borohydride with activated charcoal to reduce the nitro, better yields. Then follow up with formic acid, formaldahyde. We got 50% yield. The precurser you mention is way over priced. Other methods are more efficiant and cheaper.

 

[hider8028]

sir, can i learn for you?

 

[DIRECTLABEXPRESS]

Hi bro, we are not in the business of teachers, but maybe if you have a specific question we could attempt to help.

 

[hider8028]

can you prepare your method, raw materials and steps for me,your help is not free

 

[weare.kaos]

tenho algumas dúvidas, pode me ajudar ?

quais são as condições para a primeira ocorrência de redução? pó de zinco e ácido fórmico, reagem sob aquecimento ou aquecimento ? eu preciso de um reator encamisado para que a reação seja possível?

não me leve a mal, sou novato. Mas sei que há um grande vácuo de mercado, em meu país, a fonte sólida é o desvio das farmacêuticas. apenas .