5-Meo-Mipt from 5-Meo tryptamine , will this work ?

Bennychairman

Don't buy from me
New Member
Joined
Jul 7, 2022
Messages
25
Reaction score
17
Points
3
thikal has some complicated method i've wonder if there is another way ,

generally something like this.

10g of 5-MeO-Tryptamine is dissolved in methanol and stirred in 5g of acetone for 24 hours. Afterwards the reaction vessel is left to cool in the freezer and transferred to an ice bath/dry ice bath. 70mL of 37% formaldehyde dissolved in methanol is added all at once, and the reaction mixture is stirred for 30 mins before 10g of NaBH4 powder is added very slowly such that the temperature of the reaction does not exceed 0C.

After all of the NaBH4 has been added the mixture is left to stir for one hour at room temperature, filtered if there are solids formed, HCl is added until the mixture has a pH of about 3, and the methanol is evaporated (preferably under vacuum). The remaining mixture is then washed with 3x 25mL DCM, which is discarded/recycled. NaOH is then added to the aqueous solution until the pH is about 10, and the solution is again washed with 3x 25mL DCM which is collected and saved.

5-MeO-MiPT freebase is now dissolved in the DCM. Do what you want with it from there.

how does this sound ? , basically do the imine with acetone first , then methylation with formalin like dmt , even if yields will be low , few grams is enough its very potent.

any suggestions or tweaks ? ill try in in about a month would you do something different ?
 

Attachments

  • IsE7nTKRi6.jpg
    IsE7nTKRi6.jpg
    166.4 KB · Views: 433

chemistrydude

Don't buy from me
Resident
Joined
Jul 2, 2022
Messages
74
Reaction score
18
Points
8
Sounds good, but if you don't have DCM you can replace on ethyl alcohol.
 

chemistrydude

Don't buy from me
Resident
Joined
Jul 2, 2022
Messages
74
Reaction score
18
Points
8
Using NaBH4 might be dangerous replace on Na2CO3
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,404
Solutions
3
Reaction score
2,365
Points
113
Deals
1
thikal has some complicated method i've wonder if there is another way ,

generally something like this.

10g of 5-MeO-Tryptamine is dissolved in methanol and stirred in 5g of acetone for 24 hours. Afterwards the reaction vessel is left to cool in the freezer and transferred to an ice bath/dry ice bath. 70mL of 37% formaldehyde dissolved in methanol is added all at once, and the reaction mixture is stirred for 30 mins before 10g of NaBH4 powder is added very slowly such that the temperature of the reaction does not exceed 0C.

After all of the NaBH4 has been added the mixture is left to stir for one hour at room temperature, filtered if there are solids formed, HCl is added until the mixture has a pH of about 3, and the methanol is evaporated (preferably under vacuum). The remaining mixture is then washed with 3x 25mL DCM, which is discarded/recycled. NaOH is then added to the aqueous solution until the pH is about 10, and the solution is again washed with 3x 25mL DCM which is collected and saved.

5-MeO-MiPT freebase is now dissolved in the DCM. Do what you want with it from there.

how does this sound ? , basically do the imine with acetone first , then methylation with formalin like dmt , even if yields will be low , few grams is enough its very potent.

any suggestions or tweaks ? ill try in in about a month would you do something different ?
BennychairmanWhere did you take this manual?
 

Bennychairman

Don't buy from me
New Member
Joined
Jul 7, 2022
Messages
25
Reaction score
17
Points
3
Where did you take this manual?
G.Patton
just a friend came up with it , i guess i forgot , after stirring with acetone , reduce with nabh4 , and the methylate with formalin and nabh4 , how does that sound.
i came across a MIPT synthesis from tryptamine , i guess it would be the same only use 5meo-t
 

HerrHaber

Don't buy from me
Resident
Joined
Jan 15, 2023
Messages
436
Reaction score
227
Points
43
just a friend came up with it , i guess i forgot , after stirring with acetone , reduce with nabh4 , and the methylate with formalin and nabh4 , how does that sound.
i came across a MIPT synthesis from tryptamine , i guess it would be the same only use 5meo-t
BennychairmanI was writing it in my notebook as it occured to me that the acetone imine must be first reduced to T-HN-iPr brfore methylation...
 

Bennychairman

Don't buy from me
New Member
Joined
Jul 7, 2022
Messages
25
Reaction score
17
Points
3
It sound interesting, try and share us your results please =)
G.Patton
gladly id like to contribute to the forum , here is a synthesis for Mipt from tryptamine from reddit , so in theory just doing it with 5meo-t , should yield 5meo-mipt right ? , only suggestion , what would be better for the first step for the formation of 5 meo - Isopropyl ? , stirring for 24 hours at RT to give imine , or do it like the reaction bellow ? because in this post it seems 15m at 0C it enough and then reduce it.

4 grams of tryptamine (25mmol) was dissolved into 100ml of methanol, this was cooled to 0c in an ice salt bath. 3.70ml (50mmol) of acetone was added to the stirring methanol, 15 minutes later 1.45g of NaBH4 (37.5 mmol) was added slow enough to keep the solution below 5c. This was stirred for 60 minutes in the ice bath. After 60 minutes it was stirred in a 35c water bath to quench the NaBH4, the methanol was cooled back to 0c and 2.20ml (25mmol) of a 37% formaldehyde solution was added. This was stirred for 60 minutes followed by slow addition of 0.65g of NaBH4 (17.5mmol) , this was quenched and the formaldehyde addition was repeated. After the addition it was stirred at RT for 48 hours. The reaction mix was then poured into 100ml of 5% acetic acid, the methanol was distilled off and the acid phase was washed 2x30ml xylene. The acid phase went from a amber color to a very light yellow. The aqueous phase was basified and extracted 3x25ml of acetone, the acetone was dried over MgSO4 and precipitated as the fumerate salt. 2.38g of MiPT fumerate was recovered.
 

HerrHaber

Don't buy from me
Resident
Joined
Jan 15, 2023
Messages
436
Reaction score
227
Points
43
gladly id like to contribute to the forum , here is a synthesis for Mipt from tryptamine from reddit , so in theory just doing it with 5meo-t , should yield 5meo-mipt right ? , only suggestion , what would be better for the first step for the formation of 5 meo - Isopropyl ? , stirring for 24 hours at RT to give imine , or do it like the reaction bellow ? because in this post it seems 15m at 0C it enough and then reduce it.

4 grams of tryptamine (25mmol) was dissolved into 100ml of methanol, this was cooled to 0c in an ice salt bath. 3.70ml (50mmol) of acetone was added to the stirring methanol, 15 minutes later 1.45g of NaBH4 (37.5 mmol) was added slow enough to keep the solution below 5c. This was stirred for 60 minutes in the ice bath. After 60 minutes it was stirred in a 35c water bath to quench the NaBH4, the methanol was cooled back to 0c and 2.20ml (25mmol) of a 37% formaldehyde solution was added. This was stirred for 60 minutes followed by slow addition of 0.65g of NaBH4 (17.5mmol) , this was quenched and the formaldehyde addition was repeated. After the addition it was stirred at RT for 48 hours. The reaction mix was then poured into 100ml of 5% acetic acid, the methanol was distilled off and the acid phase was washed 2x30ml xylene. The acid phase went from a amber color to a very light yellow. The aqueous phase was basified and extracted 3x25ml of acetone, the acetone was dried over MgSO4 and precipitated as the fumerate salt. 2.38g of MiPT fumerate was recovered.
Bennychairmanthis one makes a lot more sense
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,404
Solutions
3
Reaction score
2,365
Points
113
Deals
1
so in theory just doing it with 5meo-t , should yield 5meo-mipt right ?
BennychairmanHi, yes
only suggestion , what would be better for the first step for the formation of 5 meo - Isopropyl ?
Why do you think than IPA is better than MeOH (which is shown in both methods)?
stirring for 24 hours at RT to give imine , or do it like the reaction bellow ? because in this post it seems 15m at 0C it enough and then reduce it.
You can use TLC to check the reaction completion
 

Opal

Don't buy from me
New Member
Joined
Jul 29, 2022
Messages
4
Reaction score
0
Points
1
I don't grasp the order of the reactions, why do you add the formaldehyde before the NaBH4, wouldn't you first want to reduce the isopropyl-imine to the isopropyl-amine, and then add the formaldehyde, and then reduce it again, yielding MiPT
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,404
Solutions
3
Reaction score
2,365
Points
113
Deals
1
I don't grasp the order of the reactions, why do you add the formaldehyde before the NaBH4,
OpalI think you understood wrong. There is correct sequence: formaldehyde and than NaBH4
70mL of 37% formaldehyde dissolved in methanol is added all at once, and the reaction mixture is stirred for 30 mins before 10g of NaBH4 powder is added very slowly
 

Opal

Don't buy from me
New Member
Joined
Jul 29, 2022
Messages
4
Reaction score
0
Points
1
I think you understood wrong. There is correct sequence: formaldehyde and than NaBH4
G.PattonBut don't you need to first reduce the imine formed by the reaction of the tryptamine with acetone? That is
Base tryptamine + acetone -> imine
imine + nabh4 -> isopropyltryptamine
isopropyltryptamine + formaldehyde -> another imine
this another imine + nabh4 -> MiPT

I didnt know that the unreduced imine could react with the formaldehyde. Is that so?
 

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,404
Solutions
3
Reaction score
2,365
Points
113
Deals
1
But don't you need to first reduce the imine formed by the reaction of the tryptamine with acetone? That is
Base tryptamine + acetone -> imine
imine + nabh4 -> isopropyltryptamine
isopropyltryptamine + formaldehyde -> another imine
this another imine + nabh4 -> MiPT

I didnt know that the unreduced imine could react with the formaldehyde. Is that so?
OpalI asked him to share result of this synthesis. Your scheme has more sense. Author, probably, got some small yield by reason that everything react in one pot.
 

Bennychairman

Don't buy from me
New Member
Joined
Jul 7, 2022
Messages
25
Reaction score
17
Points
3

G.Patton

Expert
Joined
Jul 5, 2021
Messages
2,404
Solutions
3
Reaction score
2,365
Points
113
Deals
1
@Bennychairman @Opal An author writes about 2.38g from 4 grams tryptamine. 44% yield. Not so bad according low difficulty of this synthesis.
 

HerrHaber

Don't buy from me
Resident
Joined
Jan 15, 2023
Messages
436
Reaction score
227
Points
43
what about getting it from Isopropyl thyptamine with a direct methylatin by Me2SO4but I ont know if 1H is prone to be methylated therefore a most convinient protection on the nr. ! with good recovery wrhyng kadt was assas8
 

HerrHaber

Don't buy from me
Resident
Joined
Jan 15, 2023
Messages
436
Reaction score
227
Points
43
what about getting it from Isopropyl thyptamine with a direct methylatin by Me2SO4but I ont know if 1H is prone to be methylated therefore a most convinient protection on the nr. ! with good recovery wrhyng kadt was assas8
HerrHaberPlease excuse my languade for I was sedated and tried to write in a hurry, I meant if by any chance dimethylsulphate could be used to methylate monoisopropyltryptamine without methylating the heterocyclic indole nitrogen (N1) and what may be the most convenient protection/deprotection method? thank you! And sorry for both my "french" and lack of common sense, I promise I'm better when not sedated.

P.S. administration should refuse me posting incoherent chemistry.
 
  • Free product samples

    Testing products from new vendors and manufacturers.

    Get free samples for testing now!

  • Always stay in touch with BB forum. Element/Matrix.

    Connect notifications to always stay in touch with the forum!

    Connect

  • The BB Forum team is looking for cooperation:

    • Traffic arbitrage specialists
    • Spammers
    • Advertising agencies
    • Bloggers/Vloggers
    • TOR sites directories
    • Creative people who can create viral content
    • Administrators of Telegram Channels and Groups

      We will pay more for your traffic than our competitors! $0.1 per visitor!!!If you are interested in, write to the administrator.
Top