Complete LSD Synthesis?

Blammo

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I'm wondering if anyone on this forum would be so kind as to post a complete synthesis of lsd, starting from d lysergic acid methyl ester, all the way to the finished product.

This would revolutionize lsd production.

Imo, since this forum facilitates the distribution of precursors, it would be a a good business move to do so. There would be more volume sold, and more money coming in.

Ideally it would be comprehensive. Starting with the hydrolysis of the methyl ester, using a peptide coupling reagent (one such write up already exists), alternatives to diethylmethylamine, or dimethylethylamine, I forget which, alternative coupling reagents, and how to do and the correct solvents for column chromatography.

Something like this would be incredibly useful and profitable.
 

GnarleyBarley

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"This would revolutionize lsd production."
No it fucking wouldn't! the DLame to Lysergic acid is not hard and you can find it in publications.

"Something like this would be incredibly useful and profitable."
How is spoonfeeding you profitable for anyone but yourself?

Here is a little spoonfeeding for you:
DrKdguW9hi


Now, why don't you contribute something?
 

Blammo

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Why don't you be polite and mature?

Now tell me, does the hydrolysis lead to isolysergic acid? My research says it does, and that is important information.

Point is, this whole forum is literally "here are guides to synthesize drugs without any chemistry knowledge" and you are crying hysterically about me not contributing, getting butt hurt over asking for something this forum is literally already doing, and centered around, chemistry write ups for those with little chemistry knowledge.....

Who is the real jerk here? The guy asking for yet another guide, like the countless ones already on here, that are approved by moderators and the entire forum....or the guy throwing a complete hissy fit over someone asking for something this forum is literally designed to provide....

Don't worry, we all know the answer
 

GnarleyBarley

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I am not irritated by the questions I am annoyed by the made up and ridiculous statements
"This would revolutionize lsd production." (as if this is in any way new)
"Something like this would be incredibly useful and profitable."

Also I was being polite by offering you the hydrolysis, also you can just turn iso-lsd to LSD later so iso is not a problem.
 

Blammo

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You were being condescending while trying to show that I was being lazy....that's what's called being two faced, especially when you claim being "generous" as your motivation....

So you're telling me a working step by step guide, from tart to finish, including all the little details, wouldn't make lsd more common and able to be synthesized by more people? More people making it, more demand for precursors, even cheaper lsd prices for the consumer. It would make it so there wouldn't be anything like when pickard was busted, a huge blow to the lsd community because a large scale chemist got caught. Instead, smaller chemists would be able to supply demand, and smaller scale chemists means if one is busted, there are plenty more to follow, and everyone can do it now, so there is no short supply of capable people. Unlike now, where you have to have more chemistry knowledge than most do.....

So that wouldn't change things, one bit? That wouldn't democratize lsd synthesis?

How is this any different than any of the guides on here, that already walk you step by step through the entire process of making meth, mdma, etc?
 

mycelium

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I believe what he was trying to say is that someone who has the skill to do so also has the skills to use the search function...
and to copy one set of directions, say for the hydrolysis, and paste them onto a new document where you have other instructions for coupling the newly formed lysergic acid with the diethylamine and a peptide-coupling reagent.
Unlike almost all of the other syntheses presented on this forum(most of which are copy and paste, as well ,with some editing and bold/italics/spacing/etc ), this is one with the least published information, etc(sorry my words don't seem to make much sense).
There is a video, and , wait, lemme find the link


This is how to make acid starting with D-LAME, although he makes several statements that do not align with the facts, such as stating this is hofmanns synthesis(no I don't believe it is, as they never had to make the methyl ester because lysergic acid was not on any watch list), etc.
This video also goes as far as the LSD base, and the dude says "this is liquid acid" nope, but crystalizing with .223g of d-tartaric acid per g of LSD base, makes the LSD tartrate, and recrystalie in dry MeOH

That video uses a way to cleave the ester group off, then uses shulgins synth (as outlined in tihkal )

you can also look up:
garbrecht lsd method
casey hardison pybop lsd method (quick and fast and amazing,)

there is a ton of info out there, if you look for it. maybe you could make a post containing all lsd informatiin in one post...since itndoeant exist and you want it to.

there are only a couple vendors with D-LAME, and two have it in small amounts, 10g. lots have kilos. 1g of dlame is equal to .25g la
 

GnarleyBarley

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According to
P3jy5VoYSO
this hydrolysis of the methyl ester, the yield of LA is 72% (4.59g D-lame turns into 3,14g LA) way more than 25%

Am I missing something or are you using the yields from that video posted?
 

mycelium

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Yes I was using the yield posted front he video
 
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