Discussion: 5-MEO-xx & Injectable opiates

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5-MEO-xx & Injectable opiates​

5-MeO-xx compounds are a group of psychoactive substances structurally related to 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT), a naturally occurring psychedelic compound found in various plant species and in the venom of the Bufo alvarius toad. These substances are part of the tryptamine class and are known for their potent psychedelic effects.

The primary mechanism of action for 5-MeO-xx compounds is agonism at serotonin (5-HT) receptors, particularly the 5-HT1A and 5-HT2A subtypes. The 5-HT2A receptor is especially notable for its role in the effects of many classic psychedelics. These compounds can cause a profound alteration in sensory perception, mood, and thought processes, largely attributed to their effects on the brain's serotonin system. They may also interact with other neurotransmitter systems, but their primary effects are through serotonin receptors.

Examples of 5-MeO-xx Compounds:

• 5-MeO-DMT: The most well-known compound in this class, it's found naturally in some plant species and the venom of the Bufo alvarius toad. It's known for its powerful, short-acting psychedelic effects, which can include intense visual and auditory hallucinations, altered perception of time and space, and profound changes in emotional and introspective states.
• 5-MeO-MIPT (Moxy): A synthetic psychedelic with stimulating and entactogenic effects. It's known for its unique combination of visual, emotional, and tactile enhancements, making it distinct from more traditional psychedelics like LSD or psilocybin.
• 5-MeO-DIPT (Foxy Methoxy): Another synthetic member of the 5-MeO family, known for its stimulatory and hallucinogenic effects. It's less commonly encountered but noted for its distinct pharmacological profile compared to 5-MeO-DMT.

Injectable opiates, also known as opioids when referring to both natural and synthetic forms, primarily work by binding to opioid receptors in the central nervous system (CNS) and the gastrointestinal tract. These receptors include mu, delta, and kappa opioid receptors, with mu receptors being the most relevant for the effects of most used opiates.

When opiates bind to these receptors, they inhibit the release of neurotransmitters like substance P and GABA (gamma-Aminobutyric acid), leading to pain relief (analgesia), euphoria, and sedation. By binding to receptors in areas of the brain and spinal cord involved in pain transmission and perception, opiates decrease the sensation of pain. Opiates also act on the limbic system, affecting emotions, which contributes to their euphoric effects.

Examples of Injectable Opiates:

• Morphine: Often used for severe pain, morphine is a standard reference point for measuring the efficacy of other opiates.
• Fentanyl: A synthetic opioid, fentanyl is much more potent than morphine and is used for severe pain, often in anesthesia or for pain management in cancer patients.
• Hydromorphone (Dilaudid): Another potent opioid, used for severe pain and as an alternative to morphine for those who may have adverse reactions to morphine.
• Heroin (Diacetylmorphine): Although not used clinically in most countries, it is a well-known illicit opiate, converted back to morphine in the brain.

While injectable opiates primarily act on opioid receptors, they can indirectly affect other neurotransmitter systems, including the serotonin and dopamine systems, but they do not directly bind to these receptors.


The interaction between 5-MeO-xx compounds and injectable opiates involves complex pharmacological dynamics. While there is limited research on the direct interactions between 5-MeO-xx compounds and opiates, potential risks arise from their differing effects on the central nervous system (CNS). Opiates depress CNS activity, while 5-MeO-xx compounds are CNS stimulants, which can lead to unpredictable and potentially dangerous effects.

While there may be a perceived enhancement of the psychedelic experience or an increase in pain relief, this combination can be hazardous. The most concerning interaction is the potential for respiratory depression. Opiates significantly depress respiratory function, and combining them with other substances can exacerbate this effect.

Side Effects and Dangers:

• Psychological Distress:The intense psychological effects of 5-MeO-xx compounds can be overwhelming, especially when combined with the disorienting effects of opiates.
• Physical Health Risks: Each class of substances carries its own health risks (e.g., dependency and tolerance with opiates, potential cardiac risks with psychedelics), which may be compounded when used together
• Increased Risk of Overdose: The combination can lead to unpredictable effects on consciousness and respiratory function, increasing the risk of overdose.

We have not come across confirmed data on acute, rapid, and fatal conditions associated with this combination. At the same time, there is no evidence of any worthwhile positive recreational effects that could cover the risks of this combination. More research is needed to understand this interaction fully, and such combinations should be avoided outside proper settings and experience.

All things considered, we recommend avoiding this combination.