how to cure cocaine reverse tolertance

[amphguy7686]

i need to know chemicals that downregulates dopamine receptors,I am a cocaine, crack, methylphenidate and amphetamine user and have recently developed reverse tolerance needing fewer doses to go into a psychotic break, how can I build up my tolerance again?

 

[Paracelsus]

Hello. This is an interesting question. Please specify - how long have you been using these substances and what dosages have you reached before the reverse tolerance manifested itself? When did it start approximately? Do you have any chronic diseases? Maybe there is a start of taking medications?

 

[Willaim2023]

hi, reduce the amount of food you consume before your next drink, reduce intense exercise and active thoughts, and quit smoking, drinking and drinking spicy and stimulating edible items.

 

[Mr Gonzo]

It is my understanding that prolonged use of these chemicals, cause the receptor site to reduce in receptive size from over stimulation. I'm not sure how this is reversed?

 

[Paracelsus]

Yes, tolerance develops in part because of this. But there are many more reasons, and we cannot fully grasp an important part of them. Nevertheless, there is poorly confirmed evidence of a decrease in tolerance after a long (actually long) break in the use and/or use of certain pharmacological drugs, such as Memantine. I repeat, this is not even scientific data, but rather the feedback of individual people after experimenting on themselves.

 

[Mr Gonzo]

I agree 100% with that, I was being specific about the chemical being cocaine. Reading what I have written I should have been more clear with that, non the less addictions, miss use and tolerance are all interesting and not given enough thought or time being discussed. I recently quit nicotine after 25 years use, it was my 5th attempt, this time it was like I did not even try to quit I just stopped. This gets me thinking addiction is 50% a issue of the human condition.

 

[NinjaFlakkaZombie]

Did I misread this? OP is concerned about going psychotic. As in the problems u get from pyros. He's not concerned about tolerance.

If I haven't misread I'd advise you to see a psychiatrist and find a neuroleptic that you could either take if ur getting super manic or to take while youbtske a break this second option is gonna be hard I'm on the same meds as u and i couldnt stop Ritalin and unless il broke cocaines even harder) if these drugs are making u pduchotic seek professional help (but I'd advise u to keep this from wholever is writinhng ur Ritalin scripts buy thats up to u)

 

[Paracelsus]

Yes, the discussion has moved towards tolerance, but in order to give the OP at least an approximate answer to the case, more details are needed. In general terms, of course, it is worth going to the doctors, being examined and possibly taking medications. These are obvious recommendations.

 

[amphguy7686]

Yes, the discussion has moved towards tolerance, but in order to give the OP at least an approximate answer to the case, more details are needed. In general terms, of course, it is worth going to the doctors, being examined and possibly taking medications. These are obvious recommendations.

Paracelsusparacelsus do you think bpc 157 can help me?

 

[Paracelsus]

paracelsus do you think bpc 157 can help me?

amphguy7686BPC 157 is a very interesting and potentially promising substance. However, in research, it demonstrates effects that are the opposite of your requests, as far as I understood. Thus, BPC 157 may counteract the consequences of dopamine-related nigrostriatal neuronal damage, dopamine vesicle depletion, dopamine receptors blockade, and the consequences of reduced dopaminergic activity. All these notions suggest a special interaction of gastric peptide with dopaminergic system and an ability of BPC 157 to counteract the effect of a noxious agent within the central dopaminergic system and through dopamine, the interaction with other systems as well. In addition, BPC 157 acts on other neurotransmitter systems. It is difficult to predict how your neurochemistry will react to taking it.

 

[amphguy7686]

I used a lot of cocaine, Ritalin and crack over 3 years and now I'm feeling a kind of reverse tolerance with sensitization of doopaminergic receptors, I'm experiencing psychotic episodes with less dosage than before, do you think memantine can solve my problem?I read some articles that say dopamine agonists can help, but what I wanted was substances to reset my receptors

 

[Paracelsus]

I used a lot of cocaine, Ritalin and crack over 3 years and now I'm feeling a kind of reverse tolerance with sensitization of doopaminergic receptors, I'm experiencing psychotic episodes with less dosage than before, do you think memantine can solve my problem?I read some articles that say dopamine agonists can help, but what I wanted was substances to reset my receptors

amphguy7686Can you specify how psychotic episodes manifest themselves? How exactly have the dosages changed? Do you have any psychiatric diagnoses? If it is more convenient, you can write to me in private messages.

 

[amphguy7686]

do you guys think that bpc 157 can help me?

 

[craris100]

Ketotifene fumarate and diphenhydramine clean the dopamine and serotonine receptors plus increasing them density.

Ketotifene fumarate 2mg every day before sleep
Diphenhydramine 50mg befote sleep.

After 1 day you can feel the difference taking a simple coffee

 

[craris100]

Ketamine and dextrometorphane stimulate NMDA receptors increasing dopamine and serotonine sensivity.

You can combine tirosine with your stimulants for enhance effects.

 

[amphguy7686]

yes but i think my problem is supersensitivity in certain points of my brain, i dont know who is better a sensitizing or desensitizing agent, i think bpc 157 can help me

 

[Emelrich]

yes but i think my problem is supersensitivity in certain points of my brain, i dont know who is better a sensitizing or desensitizing agent, i think bpc 157 can help me

amphguy7686what makes you believe bpc-157 would be of help?