JWH-018 synthesis

[WillD]

Can anyone upload a video? About JWH-018 I am a novice

a114488No video, but I can advise in detail on the process here, private message or XMPP. I have enough practical experience on this synthesis.

 

[aa1178251182]

No video, but I can advise in detail on the process here, private message or XMPP. I have enough practical experience on this synthesis.

William DampierCan AlCI3 aluminum chloride replace nitromethane? Can't buy nitromethane.

 

[WillD]

No, time does not decrease. We cannot use nitromethane, we get a product, but the yield will be lowered, and it will be more difficult to clean. Maybe you can buy 1,1,1,3,3,3-hexafluoroisopropanol (HFIP)? Although its price does not allow being the best option.

 

[aa1178251182]

No, time does not decrease. We cannot use nitromethane, we get a product, but the yield will be lowered, and it will be more difficult to clean. Maybe you can buy 1,1,1,3,3,3-hexafluoroisopropanol (HFIP)? Although its price does not allow being the best option.

William DampierSir, can HFIP replace nitromethane?

 

[Claudio51]

Sir, can HFIP replace nitromethane?

aa1178251182I noticed that you do not use the column to purify the products ... which purification method do you use ?

 

[Claudio51]

I noticed that you do not use the column to purify the products ... which purification method do you use ?

Claudio51I noticed that you do not use the column to purify the products ... which purification method do you use ?

 

[French chocolate]

Does anyone have access to this noid ?

 

[Marc-Benzo]

Does anyone have access to this noid ?

French chocolateThat's the million dollar question Frenchie. I guess I'm below a noob because I'm definitely not a chemist but I can move some shit.

 

[WillD]

Is this reaction very exothermic? what are some of the safety precautions that one should involve?

MrSungWhere it is written about cooling, yes, the reaction is exothermic. Add reagents very neat and slow

 

[Khaled]

Where it is written about cooling, yes, the reaction is exothermic. Add reagents very neat and slow

William DampierWhat is an alternative to Tin (IV) chloride?

 

[G.Patton]

Can I use tin tetrachloride solution in hexane

Dr.joeProbably yes, because Hexane and DCM are miscible solvents. Take into account that you have to count volume of SnCl4 in hexane in according with concentration to add equal amount SnCl4 as in this manual.

 

[Khaled]

Probably yes, because Hexane and DCM are miscible solvents. Take into account that you have to count volume of SnCl4 in hexane in according with concentration to add equal amount SnCl4 as in this manual.

G.PattonWhat is an alternative to Tin (IV) chloride?

 

[curiousbob221]

Hi, we ordered the 109555-87-5 direct from supplier, but they sent 83-34-1.....3-methylindole.
Could this product replace the 109555-87-5 in this synthesis?
If not is there another route using the 83-34-1 or is this product no good.
Help appriechated.

 

[HerrHaber]

Hi, we ordered the 109555-87-5 direct from supplier, but they sent 83-34-1.....3-methylindole.
Could this product replace the 109555-87-5 in this synthesis?
If not is there another route using the 83-34-1 or is this product no good.
Help appriechated.

curiousbob221Sorry mate the suppliers seem to be mocking you 3-methyl indole is also known as skatole and it is the litteral smell of shit (I'm afraid I'm not joking) and unfortunately it can't be used for the preparation because the 3 position is occupied by methyl (did not say it is impossible since oxidation of the methyl to carboxylic acid which in turn could theoretically rather than in practice be converted to the acyl chloride to further Friedel-Crafts it with naphtalene is just my imagination and never heard of anyone doing this) Best advice is buy indole since it's probably the cheapest building block in the whole molecule.

 

[abbadon]

hi friends, i want ask, the ones with success in JWH-018 synthesis:
is anyone located in europe and able, to sell maybe a small amount or more of the finished product?
pm please

 

[jarmy]

Please help about Tin (IV) chloride, I could not get it, and I found Tin (Il) chloride in a solid state, not a liquid, so can I use it in the reaction

 

[HerrHaber]

Please help about Tin (IV) chloride, I could not get it, and I found Tin (Il) chloride in a solid state, not a liquid, so can I use it in the reaction

jarmySnCl2 (stannous chloride) is not a strong Lwis acid that is needed to catalize the acylation reaction; you can find a preparation on youtube where the target compound is tin triblutyl hydride but SnCl4 is prepared as an intermediate from Sn metal powder in a heated tube thru which Cl2 is passed. This is hardcore chemistry so it shouldn't be attempted by amateurs not that jwh018 is

 

[jarmy]

SnCl2 (stannous chloride) is not a strong Lwis acid that is needed to catalize the acylation reaction; you can find a preparation on youtube where the target compound is tin triblutyl hydride but SnCl4 is prepared as an intermediate from Sn metal powder in a heated tube thru which Cl2 is passed. This is hardcore chemistry so it shouldn't be attempted by amateurs not that jwh018 is

HerrHaberThank you for your interest and reply. Is there another alternative to it and what it is

 

[HerrHaber]

Thank you for your interest and reply. Is there another alternative to it and what it is

jarmy

here it is; please be safe!

 

[madmoney69]

Please help about Tin (IV) chloride, I could not get it, and I found Tin (Il) chloride in a solid state, not a liquid, so can I use it in the reaction

jarmyI have tin 4chloride.
europe only

 

[jarmy]

Thank you very much

 

[jarmy]

In the second and final step, I fixed the temperature at 70 degrees Celsius, and in the end the product came out weak. Accordingly, what is the temperature required for the reaction in the last stage?

 

[Rita]

Jwh is for beginners. For the old people, it is weak but active

 

[charmingcho]

What is the role of Na2So4?

 

[madmoney69]

What is the role of Na2So4?

charmingchodrying agent

 

[HerrHaber]

drying agent

madmoney69only if anhydrous

 

[charmingcho]

In the first step, I succeeded in obtaining it in solid form. And I tried to recrystallize it with ethanol, but it didn't get well, so I recrystallized it with IPA. And the second step is the reaction I tried to recrystalization with ipa without solidifying it properly because I was in a hurry. But it was not obtained in a solid state. Do I have to do something solid when recrystallizing? And what is the most suitable recrystallization solvent in step 2?

 

[madmoney69]