(+)-Lysergic acid total synthesis

[V€ctor Company]

If I follow this synthesis and complete it, can I start blotting this onto my sheet to produce 200-300ug tabs or do I need to follow William dampiers synthesis (link below) to have LSD I can start blotting onto the papers.

William dampiers synthesis:

LSD synthesis from lysergic acid via PyBOP

Reagents: Lysergic acid (cas 82-58-6)2.80 g; Methylene chloride (DCM; CH2Cl2) 190 ml; N,N-Diethylmethylamine (cas cas 616-39-7) 1.81 g; PyBOP (cas 128625-52-5) 5.70 g; Diethylamine (cas 109-89-7) 0.84 g; Ammonium hydroxide (NH4OH) 100 ml 7.5 M; Sodium bicarbonate (cold saturated aq solution)...

bbgate.com

 

[nickelred_afdav]

If I follow this synthesis and complete it, can I start blotting this onto my sheet to produce 200-300ug tabs or do I need to follow William dampiers synthesis (link below) to have LSD I can start blotting onto the papers.

William dampiers synthesis:

LSD synthesis from lysergic acid via PyBOP

Reagents: Lysergic acid (cas 82-58-6)2.80 g; Methylene chloride (DCM; CH2Cl2) 190 ml; N,N-Diethylmethylamine (cas cas 616-39-7) 1.81 g; PyBOP (cas 128625-52-5) 5.70 g; Diethylamine (cas 109-89-7) 0.84 g; Ammonium hydroxide (NH4OH) 100 ml 7.5 M; Sodium bicarbonate (cold saturated aq solution)...

bbgate.com

V€ctor CompanyIf you had the facilities or knowledge to carry out this synthesis, you wouldn't have to ask this question.

This is a quite dangerous and complicated procedure, utilizing procedures like catalytic hydrogenation which require special equipment, not to mention the facilities to handle dangerous chemicals such as thionyl chloride and hydrogen cyanide. Plus, if you did any cursory research at all on LSD manufacture you would understand that this synthetic procedure is hardly useful to the clandestine chemist, and that most clandestine production of LSD gets lysergic acid from hydrolysis of related (gray-market sourced) compounds.

I would recommend reading through a general chemistry and an organic chemistry textbook and starting with a simpler synthesis of another compound. You'll probably kill yourself if you try this synthesis with your current level of knowledge.

 

[V€ctor Company]

If you had the facilities or knowledge to carry out this synthesis, you wouldn't have to ask this question.

This is a quite dangerous and complicated procedure, utilizing procedures like catalytic hydrogenation which require special equipment, not to mention the facilities to handle dangerous chemicals such as thionyl chloride and hydrogen cyanide. Plus, if you did any cursory research at all on LSD manufacture you would understand that this synthetic procedure is hardly useful to the clandestine chemist, and that most clandestine production of LSD gets lysergic acid from hydrolysis of related (gray-market sourced) compounds.

I would recommend reading through a general chemistry and an organic chemistry textbook and starting with a simpler synthesis of another compound. You'll probably kill yourself if you try this synthesis with your current level of knowledge.

nickelred_afdavThanks for the honest advice man, a noob chemist like me should stick to importing it until I have acquired some more experience

 

[azides]

If you had the facilities or knowledge to carry out this synthesis, you wouldn't have to ask this question.

This is a quite dangerous and complicated procedure, utilizing procedures like catalytic hydrogenation which require special equipment, not to mention the facilities to handle dangerous chemicals such as thionyl chloride and hydrogen cyanide. Plus, if you did any cursory research at all on LSD manufacture you would understand that this synthetic procedure is hardly useful to the clandestine chemist, and that most clandestine production of LSD gets lysergic acid from hydrolysis of related (gray-market sourced) compounds.

I would recommend reading through a general chemistry and an organic chemistry textbook and starting with a simpler synthesis of another compound. You'll probably kill yourself if you try this synthesis with your current level of knowledge.

nickelred_afdavYes it's not too difficult. but if you have to ask basic questions like what is BASE hydrolysis and "How to cleave methyl esters" you need lots to learn. However it's all here not including the Dihydro compounds as well