Dichloromethane, dichloroethane work great, makes the job a lot easier, getting a stab from NaBH4 also works great. Additional acid can not be used for the stab, the reaction is slower due to the lack of additional acid, but in dichloroethane the reaction is faster than in THF. The yield is presumably above 90 percent, the exact yield will be published later, after a few checks.
Methamphetamine synthesis from 1- Phenyl -2 Propanone (P2P) by reductive amination with Sodium Triacetoxyborohydride (STAB)
- Thread starter K-Cyanide
- Start date
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- Tags
- methamphetamine p2p synthesis
Does this work in the same manner with ammonia or ammonium acetate to form amphetamine?
Need an easy way to go to amphetamine from the ketone. Titanium(IV)isopropoxide is an option, but expensive.
Need an easy way to go to amphetamine from the ketone. Titanium(IV)isopropoxide is an option, but expensive.
Please who knows the kind of meth one get from the reaction? D or L or DL?
Apparently one can do the reaction, including STAB synthesis, completely in DCM, but in THF it is faster and a little cleaner
Only downside would be more nabh4 used
Ill try this soon and share my results
Only downside would be more nabh4 used
Ill try this soon and share my results
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