What is "best" depends on a lot of constraints, I guess.
For one NaBH4 route, see
"Fully Validated, Multi-Kilogram cGMP Synthesis of MDMA", Stage 3: Reductive Amination to MDMA·HCl.
That is Reductive Amination of MDP2P or 1-(3,4-methylenedioxyphenyl)-propan-2-one
Of course you can create MDP2P in a different way.
Would like the best route to synthesis of mdma with nabh4 and 40% methylamine on methanol..if possible without use dcm
thanks
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