neutralization of amphetamine free base to amphetamine sulfate. questions and answers that may be bothering you.

[Mystery_chemistry]

Hello everyone . the thread was created due to the fact that I have a few unanswered questions.

questions :
1.should amphetamine free base (oil) be mixed with a solvent toluene / dcm etc before neutralization?
if so, in what proportions? 20-30% of the oil volume will be OK?

2. in what ratio to dilute sulfuric acid with IPA? does this affect performance?
I use a ratio of 1: 4 acid / IPA , I also used a ratio of 1:10 acid / IPA

3. What could be the cause of the drop in performance? I'm going down from the pH to 5-6. diluted acid is slowly added in portions of 50-100 ml. the agitator fired all the time. recently I added IPA to the oil (could it cause a drop in efficiency?) from a liter of oil I came out 700-800g after drying. the weight of the oil was 960g pH 12. I understand that about 960g of amphetamine sulphate should come out, right?

 

[G.Patton]

Hello everyone . the thread was created due to the fact that I have a few unanswered questions.

Mystery_chemistryHi. All these questions are answered or described before. Look at here.

1.should amphetamine free base (oil) be mixed with a solvent toluene / dcm etc before neutralization?

yes, ~50/50% is okay

2. in what ratio to dilute sulfuric acid with IPA? does this affect performance?
I use a ratio of 1: 4 acid / IPA , I also used a ratio of 1:10 acid / IPA

Prepare a solution of sulfuric acid in acetone in a volume ratio of 1:10. I took the technical acetone...

the weight of the oil was 960g pH 12. I understand that about 960g of amphetamine sulphate should come out, right?

Not right. 960 g Amph oil is 7.1 mole, hence, you have to get 3.55 mole of amph sulphate 1308 g.

. the agitator fired all the time.

What do you mean? Stirrer?

What could be the cause of the drop in performance?

You could lose amph sulphate during washing

 

[Mystery_chemistry]

Hi. All these questions are answered or described before. Look at here.

yes, ~50/50% is okay



Not right. 960 g Amph oil is 7.1 mole, hence, you have to get 3.55 mole of amph sulphate 1308 g.

What do you mean? Stirrer?

You could lose amph sulphate during washing

G.PattonThanks a lot for the answer, that is 1l of oil is mixed with 1l of solvent. acid with acetone or IPA in a ratio of 1:10

which solvent is the best? I would go towards the dcm, it will evaporate faster

 

[Mystery_chemistry]

Not right. 960 g Amph oil is 7.1 mole, hence, you have to get 3.55 mole of amph sulphate 1308 g.

G.Pattonhow to calculate the ratio of concentrated sulfuric acid per such volume. I know that you need to add acid slowly, but it would be nice to know how much solution you need to prepare in this ratio of 1:10

 

[G.Patton]

which solvent is the best? I would go towards the dcm, it will evaporate faster

Mystery_chemistrywhatever you want

 

[Mystery_chemistry]

I found somewhere that there is 180 ml of sulfuric acid per 1 liter of amphetamine oil. I wonder if the ratio of 180ml: 720ml IPA will give a pH of 5-6. assuming 1:10 you will need to add a lot of this solution. won't it affect performance?

aaa and I have a question about the power. does the pH have anything to do with the strength of the product? what do you think about adding 50-100g of L-phenylalanine to the finished product to enhance the effect?

 

[G.Patton]

won't it affect performance?

Mystery_chemistryYou can evaporate IPA after washing and get amph sulphate from washing solution.

does the pH have anything to do with the strength of the product?

no

what do you think about adding 50-100g of L-phenylalanine to the finished product to enhance the effect?

senseless rumors

 

[dazrich]

what does determine strength g patton my good sir?
or does it simply loose power the more you mess reaction stages up meaning if everything goes just right it will be high strength but say if it gets to hot it looses strength or is it yeild thats lost instead?
in other words what would you say is key to getting best strength?
sorry if this is in wrong place or its been described somewhere else, i cant find it if it is.