New Chinese Restrictions

[G.Patton]

General​

BB Forum team want to inform our community members about new restriction in China. As Ministry of Public Security, Ministry of Commerce, National Health Commission Ministry of Emergency Management, General Administration of Customs, State Drug Administration state, 7 substances are included in the management of precursor chemicals.

China Anti-Drug Network, Beijing, August 5 (Xinhua) -- In order to strengthen the management of precursor chemicals, the Ministry of Public Security, the Ministry of Commerce, the National Health Commission, the Ministry of Emergency Management, the General Administration of Customs, and the State Drug Administration jointly issued an announcement on August 2, 2024, deciding to include 7 substances including 4-(N-phenylamino)piperidine in the management of precursor chemicals. The announcement will take effect on September 1, 2024.

Appendix: Announcement on Including 4-(N-phenylamino)piperidine, 1-tert-butyloxycarbonyl-4-(N-phenylamino)piperidine, N-phenyl-N-(4-piperidyl)propionamide, cannabidiol, 2-methyl-3-phenylglycidic acid and its esters, 3-oxo-2-phenylbutyric acid and its esters, and 2-methyl-3-[3,4-(methylenedioxy)phenyl]glycidic acid esters in the Management of Precursor Chemicals.

With the approval of the State Council, 7 substances, including 4-(N-phenylamino)piperidine, 1-tert-butyloxycarbonyl-4-(N-phenylamino)piperidine, N-phenyl-N-(4-piperidyl)propionamide, cannabidiol, 2-methyl-3-phenylglycidic acid and its esters, 3-oxo-2-phenylbutyric acid and its esters, and 2-methyl-3-[3,4-(methylenedioxy)phenyl]glycidic acid ester, are included in the Appendix "Classification and Variety Catalog of Precursor Chemicals" of the "Regulations on the Management of Precursor Chemicals" (hereinafter referred to as the "Regulations"). The relevant management matters are hereby announced as follows:​

I. Management of 4-(N-phenylamino)piperidine, 1-tert-butyloxycarbonyl-4-(N-phenylamino)piperidine, and N-phenyl-N-(4-piperidinyl)propionamide

4-(N-phenylamino)piperidine, referred to as 4-AP, Chemical Abstracts Registration Number or CAS Number is 23056-29-3, Customs Code 2933399099; 1-tert-butyloxycarbonyl-4-(N-phenylamino)piperidine, referred to as 1-boc-4-AP, CAS Number is 125541-22-2, Customs Code 2933399099; N-phenyl-N-(4-piperidinyl)propionamide, English name Norfentanyl, commonly known as desphenethylfentanyl, CAS Number is 1609-66-1, Customs Code 2933399099. The above three substances are managed in accordance with the second category of precursor chemicals in the Appendix to the Regulations, and their production, operation, purchase, transportation and import and export activities shall comply with the relevant provisions of non-pharmaceutical precursor chemicals.​

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II. Management of Cannabidiol

Cannabidiol, also known as Cannabidiol in English, is abbreviated as CBD. Its CAS number is 13956-29-1 and its customs code is 2907299090. This substance is managed in accordance with the second category of precursor chemicals in the Appendix to the Regulations. Its production, operation, purchase, transportation and import and export activities shall comply with the relevant provisions of non-pharmaceutical precursor chemicals. Preclinical research on cannabidiol for medical purposes shall also comply with Article 10 of the Regulations on the Administration of Narcotic Drugs and Psychotropic Drugs.​

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III. Management of 2-methyl-3-phenylglycidic acid and its esters, 3-oxo-2-phenylbutyric acid and its esters, and 2-methyl-3-[3,4-(methylenedioxy)phenyl]glycidic acid esters

2-Methyl-3-phenylglycidic acid, English name is BMK glycidic acid, CAS number is 25547-51-7, customs code is 2918990090; 2-methyl-3-phenylglycidic acid esters refer to ester substances generated by the reaction of 2-methyl-3-phenylglycidic acid with various alcohols, English name is BMK glycidic acid esters, customs code is 2918990090.​

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3-Oxo-2-phenylbutanoic acid, English name is 3-oxo-2-phenylbutanoic acid, CAS number is 4433-88-9, customs code is 2918300090; 3-Oxo-2-phenylbutanoic acid esters refer to esters generated by the reaction of 3-oxo-2-phenylbutanoic acid with various alcohols, English name is 3-oxo-2-phenylbutanoic acid esters, customs code is 2918300090.​

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Methyl 3-oxo-2-phenylbutanoate (CAS number is 16648-44-5), which has been included in the "Classification and Variety Catalog of Precursor Chemicals", is controlled according to the original catalog.​

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2-Methyl-3-[3,4-(methylenedioxy)phenyl] glycidyl esters refer to esters generated by the reaction of 2-methyl-3-[3,4-(methylenedioxy)phenyl]glycidyl acid (category II precursor chemicals) with various alcohols. The English name is PMK glycidic acid esters, and the customs code is 2932999099. Methyl 2-methyl-3-[3,4-(methylenedioxy)phenyl]glycidyl ester (CAS: 13605-48-6), which has been included in the "Classification and Variety Catalog of Precursor Chemicals", is controlled in accordance with the original catalog.​

The above three substances are managed in accordance with the second category of precursor chemicals in the appendix to the Regulations, and their production, operation, purchase, transportation and import and export activities shall comply with the relevant provisions on non-pharmaceutical precursor chemicals.

This announcement shall come into effect on September 1, 2024.​

Ministry of Public Security Ministry of Commerce National Health Commission​

Ministry of Emergency Management General Administration of Customs State Drug Administration​

August 2, 2024​

Alternatives​

Nonetheless, there are alternative precursors, which are still not restricted and can be sold.

MDMA precursors:

• Catechol

Phenylacetone (P2P) precursors:

• Diethyl(phenylacetyl)malonate
• alpha-Methylstyrene
• Benzyl chloride
• Benzene
• P2NP

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Official Source​

https://www.mps.gov.cn/n6557558/c9690580/content.html

 

[WalterFan]

Appreciate it for this update, I wonder which one is most advanced replacement for bmk ?

 

[HIGGS BOSSON]

Diethyl(phenylacetyl)malonate

 

[Mona857]

In China, we call it BMK oil

 

[rasamyr]

Thanks for the update. Anyone know what would be a replacement for pmk ? Without going through Sassafras oil?

 

[G.Patton]

Catechol or Piperonal

 

[Tovenaar]

Helional

 

[Tovenaar]

With helional i mean the enamine intermediate but there are already new intermediates

 

[sassyqueen]

I was aware of the first. But not the second...

 

[YenaneY]

Can acetone enolate ion potentially under go some kind of substitution with 3,4-methylenedioxyphenyl bromide, making the acetone enolate take the place of the bromine atom?

 

[G.Patton]

Can you name this substance in IUPAC system please
I don't think that carbanion of acetone would be strong enough for SN reaction.

 

[YenaneY]

I think the IUPAC name is 1-bromo-3,4-methylenedioxybenzene. I thought about doing it in a basic environment so the acetone releases it's enolate and using a metal transfer catalyst.

 

[G.Patton]

Why do you reinvent the wheel? http://bbzzzsvqcrqtki6umym6itiixfhn...ds/mdp2p-pmk-total-synthesis-via-safrole.884/

 

[YenaneY]

Thank you, I didn't notice that

 

[MacondoNew]

Where can I find information on all banned substances in China?
Unfortunately, there is no overall picture (

 

[G.Patton]

Catalogue of Precursor Chemicals in China｜Catalogue of Precursor Chemicals Search｜Catalogue of Precursor Chemicals Download｜Latest Catalogue of Precursor Chemicals

Related catalogues of precursor chemicals include the Catalogue of Classifications and Categories of Precursor Chemicals, the Catalogue of Precursor Chemicals Subject to Import and Export Administration, and partial content of the Catalogue of Dual-Use Items and Technologies Subject to Import...

www.chemradar.com

 

[skanderbeg]

I discussed this back in May. Most of them are banned because of those retards from reuters ...

 

[arundo]

There are no other countries that would make pmk glycidates? Maybe India or others?

 

[AKWA]

India is definitely gonna fill in some of the gaps China is about to leave. And don’t forget a lot of Chinese vendors already have a stock pile in different warehouses around the world

 

[arundo]

I asked to many of them and nobody has more stock, except one I found (in theory), that still have 25kg packs, but impossible for me.

Let's see what happens.

 

[Speedfac]

Its BMK Glycidic acid (natrium salt) CAS 5449-12-7 also banned , because its only written of BMK glycidic acid, CAS number is 25547-51-7,

 

[arundo]

Well, the official chinese document, doesn't specifies the 28578-16-7, but in the text yes...

You know, bureaucrats never are experts on the matters that they legislate...