Phenylacetone (P2P) synthesis from benzaldehyde with butanone

[cokemuffin]

I saw the video, but i'm mainly interested in large scale manufacture, getting 6l chloroform that way is not really cheap and efficient. I'll probably try to further chlorinate DCM to chloroform.

 

[Sneaky.Base]

.

 

[jokerr]

I realized my mistake.
thanks a lot by faster

 

[Fenster]

I ended up with a very very dark organic layer with DCM. I then distilled this under vacuum which removed the DCM and then a yellow oil came over. This was frozen overnight and the first time needed to be manipulated to crystal, second time was 60g solid xtal mass sulfur coloured and smelling of camphor.

 

[Fenster]

@jokerr I don't think gpatton is interested. I asked for soooo much help and they seemed to just wait until I got frustrated and then disarming language by accusing me of not following procedure. I've have DM the op and no response.

I have the original forensics write up. Might shed some light. This write up is honestly dog shit here.

 

[handle]

Looks like it's a 1:4.44 ratio of benzaldehyde to butanone

 

[G.Patton]

Hi. It means that you have to combine extracts, add aqueous NaHCO3 solution and extract it (yes liquid / liquid extraction), then separate layers. You have to check pH of organic solution after this procedure. It have to be neutral (pH 6.5-7.5).

 

[skanderbeg]

Hello I have a question. Everything is clear but how do you heat that gigantic thing to 55° or reaction+stirring at high speed will generate heat itself?

 

[G.Patton]

Laboratory FAQ==>Reflux and heating techniques​

 

[Mo0odi]

Is there an alternative to peroxide hydrogen ?

 

[Ortist]

Original twodogs procedure uses perboric acid made in-situ from acetic acid & sodium perborate. Perboric route is a bit messy and requires filtering

 

[TheNut22]

I used one time performic acid, and it worked, but not as well as peracetic acid.

 

[billythekid]

per boric and GAA makes peracetic

 

[Mo0odi]

We can provide hydrogen peroxide but with a concentration of 6%

 

[Slayer]

Can we use magmetic stirer with heating function and flask as a batch reactor or any alternative for batch reactor ?

 

[Riot]

Have good day ı have question ı want to m ake small rate of synthes , is there alternative for batch reactor and can ı use acetic asid %99 as a glacial acetic asid thank you

 

[G.Patton]

Hello, this is same
Yes, you can use three-necked round bottom flask

 

[Riot]

Thanks patton

 

[Riot]

Patton ı have magnetic stirer with heater how can ı properly heat my round bottom flask ?

 

[G.Patton]

Dear Riot, read Laboratory FAQ section please.

 

[the money]

Is there a video about the synthesis of P2P from benzaldehyde

 

[Riot]

I need some help.
does heptahydrate Na2SO4 will do the work as anhydrous ?
can ı drop hcl over the time of 1.5 or hcı is necessary in this reaction
ın step1 1. we chilled in 0 degree using water bath and then we flow hcl gas or remove water bath and then flow hcl

thanks.

 

[Riot]

*edit*
hcı gas necessary in this reaction ?

 

[Sneaky.Base]

This method looks awesome, otc cheap chemicals.
Why expensive dcm while chloroform exists. If you want a long time coock you ll understand making chloroform is the job you have to do.
The write up method shared here is perfect, it shows it written by a professional . I ll wonder if there are any video a bout this method. Tnx for sharing this nice write up willi

 

[Mo0odi]

I support your words

 

[Dj.Tizo]

same here

 

[waltjr5858]

The chloroform yields are horrible from bleach and would take forever to make a decent amount. Use toulene

 

[TheNut22]

Yes, I also support, this whole synthesis works very well.