Phenylacetone (P2P) synthesis via BMK ethyl glycidate

[chem19]

@G.Patton hello,
Need your blessings and support.
In step 6 NaOH solution 30% 450 ml is required.
I have NaOH pellet. How much of these pellet are needed with how much water, to make desirable 450 ml solution.
Plz guide me, as I m getting different different answers.
Thanks in advance
Regards

 

[G.Patton]

@G.Patton hello,
Need your blessings and support.
In step 6 NaOH solution 30% 450 ml is required.
I have NaOH pellet. How much of these pellet are needed with how much water, to make desirable 450 ml solution.
Plz guide me, as I m getting different different answers.
Thanks in advance
Regards

chem19Hello
450*0.3=135g of NaOH is loaded into the beaker, add there water to reach 450 ml risk.

 

[chem19]

Hello
450*0.3=135g of NaOH is loaded into the beaker, add there water to reach 450 ml risk.

G.Patton@G.Patton Thank you so much. You are best. God bless you. If I succeed i will definitely contribute to your bb project. I wish if I could be your experimental chemistry student. Thank you so much again.

 

[Throw-off]

Anyone tried the new BMK Oil? cas 41232-97-7. A decade ago you could just get BMK powder make a solution with methanol 1:1 and drip it straight into the al/hg you would be done same day.. is hydrolysis required with all the new BMK derivatives? 5449 sodium salt sucks compared to the old school BMK.

 

[G.Patton]

Anyone tried the new BMK Oil? cas 41232-97-7. A decade ago you could just get BMK powder make a solution with methanol 1:1 and drip it straight into the al/hg you would be done same day.. is hydrolysis required with all the new BMK derivatives? 5449 sodium salt sucks compared to the old school BMK.

Throw-off

Anyone tried the new BMK Oil? cas 41232-97-7

You need to carry out alkaline hydrolysis and than acid one as for PMK glycidates.

A decade ago you could just get BMK powder make a solution with methanol 1:1 and drip it straight into the al/hg you would be done same day..

It isn't true, you couldn't make meth from BMK glycidic acid sodium salt directly. You need to get P2P at first.

 

[Throw-off]

You need to carry out alkaline hydrolysis and than acid one as for PMK glycidates.

It isn't true, you couldn't make meth from BMK glycidic acid sodium salt directly. You need to get P2P at first.

G.PattonI'm not saying it was a sodium salt, I know it wasn't a sodium salt the texture of the powder looked totally different consistency from BMK derivative 5449.

 

[guideme]

Hello experts, this is my first Post. Hope I will get response.
I got 200 ml glycidate ester
My question is how much sodium hydroxide solution,water and solvent should I use in step 11,14,15,
And HCl in step 18. Thanks

 

[guideme]

Hello experts, this is my first Post. Hope I will get response.
I got 200 ml glycidate ester
My question is how much sodium hydroxide solution,water and solvent should I use in step 11,14,15,
And HCl in step 18. Thanks

guideme@G.Patton will I get a reply.i m noob. But I have chemical access

 

[G.Patton]

@G.Patton will I get a reply.i m noob. But I have chemical access

guidemeYou can calculate them by yourself. It has a direct dependence and can be scaled down proportionately.

 

[guideme]

You can calculate them by yourself. It has a direct dependence and can be scaled down proportionately.

G.PattonG.Patton Plz correct me if I m wrong
For 700ml of Glycidic easter, you used 450 ml of 30% sodium hydroxide solution,
so for 200 ml I have to use 128.5 ml sodium hydroxide solution, and 142.8ml distilled water and 142.8 ml toulene.

Or if something else.plz notify me.

 

[G.Patton]

G.Patton Plz correct me if I m wrong
For 700ml of Glycidic easter, you used 450 ml of 30% sodium hydroxide solution,
so for 200 ml I have to use 128.5 ml sodium hydroxide solution, and 142.8ml distilled water and 142.8 ml toulene.

Or if something else.plz notify me.

guidemeHow did you calculate 700ml number? From this batch, you'll get in theory 658ml of glycidic ester (100% yield). In a real synthesis it will be less.

so for 200 ml I have to use 128.5 ml sodium hydroxide solution, and 142.8ml distilled water and 142.8 ml toulene.

proportion is correct but you need to take not 700 ml. Count it for 530ml (for instance 80% yield).

 

[panchaspsycho]

Hello experts, this is my first Post. Hope I will get response.
I got 200 ml glycidate ester
My question is how much sodium hydroxide solution,water and solvent should I use in step 11,14,15,
And HCl in step 18. Thanks

guidemeHCL addition is usually 2-3 times the amount of the glycidate powder or doing it by eye you add HCL slowly until it stops reacting with the water-glycidate solution.