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I have an Idea of a possible Synthesis route of aMT using tryptophan as the starting material.
I have looked for a synthesis like this on this forum, but I have not found anything, so if a question like this already exists I am very sorry.
The synthesis i thought of is starting with the reduction of the carboxyl groupe of tryptophan using LAH, to get an hydroxy group, and then using hydrogen iodide in the presence of red phosphorus to remove the hydroxy group and turn it into tryptamine iodide.
The tryptamine iodide would now be reduced by Lithiumaluminiumhydride to give the final product aMT
My Question now is if this synthesis would theoretically work, and what would be the ideal solvent to perform this synthesis in?
If this synthesis works aMT could be made by easily available and non suspicious recurses, which could be made with minimal equipment and knowledge.
It would be great if somebody could help me, because my chemistry skills are not really good and I do not trust myself to try this one without asking somebody if it would even work.
I have looked for a synthesis like this on this forum, but I have not found anything, so if a question like this already exists I am very sorry.
The synthesis i thought of is starting with the reduction of the carboxyl groupe of tryptophan using LAH, to get an hydroxy group, and then using hydrogen iodide in the presence of red phosphorus to remove the hydroxy group and turn it into tryptamine iodide.
The tryptamine iodide would now be reduced by Lithiumaluminiumhydride to give the final product aMT
My Question now is if this synthesis would theoretically work, and what would be the ideal solvent to perform this synthesis in?
If this synthesis works aMT could be made by easily available and non suspicious recurses, which could be made with minimal equipment and knowledge.
It would be great if somebody could help me, because my chemistry skills are not really good and I do not trust myself to try this one without asking somebody if it would even work.