Synthesis of 3,4-methylendioxybenzylmethylketone from piperonal (glycide ester route)(small scale)

[William Dampier]

This synthesis of glycidat works, but for hydrolysis would better use hydrochloric acid. And bromopropionate can replace to chloropropionate.

 

[C14]

hello one question please , the first step it is for pmk methyl glycidate or pmk ethyl glycidate,?? Thanks becouse in another forum ethyl glycidate and hier methyl

 

[C14]

Hier say pmk ethyl glycidate now i am comfused

 

[William Dampier]

Methyl, ethyl, tert-butyl, isopropyl, etc ethers

 

[ukises]

Dcm?

 

[William Dampier]

It depends on what starting reagents you have. Do you have a piperonal?

 

[realboss]

Man I have piperonal
Can I use bmk glycidate video
As a reference and use piperonal as a starting chemical and make pmk can you help man

 

[Fring]

thtas what i thought ... and in fact this is real, the problem is due to we were doing the olg GLY conversion and with this new, when we see a tottally differerent result we all thinks there's something wrong, and the key its just vacuum distillation..it losses a small part of water and gives the Ketone... different colour, very dark red or brown

 

[William Dampier]

The chemical structure of any ester of glycidate consists of the same acid and alcohol. What alcohol was for etherification - such an acid ester. Saponification of ethers with alkali - in all cases, the same.

The typical Darzen reaction uses the ethyl version of the ether.

 

[summer_child]

Ethyl a-bromopropionate might present a challenge to get or make. One could replace it with ethyl propionate and perform an epoxidation with performic acid. View attachment 5322 View attachment 5323

 

[William Dampier]

Well available in China
Yes, you are now talking about another interesting route. Alpha-methylcinnamic acid is also available in China.

 

[summer_child]

True , but I always like to think of synthesis pathways that can be completed by going to the local hardware store even if they are less efficient.
Edit: I noticed the picture is my other posts don't show up so I added them here

 

[2-79-790125]

This would be a great one to flesh out for the "Simplest Recipes" project. Perhaps start with listing the CAS# next to each chemical. I don't think any of these starting chemicals are on the watch list in the US............ nice. : )

 

[realboss]

Man I have piperonal
Can I use bmk glycidate video
As a reference and use piperonal as a starting chemical and make pmk can you help man