Reaction scheme:
View attachment 1416
Synthesis:
1. 25 liters of acetonitrile and 5 liters of water were added into the 200 L reactor.
2.1000 g a-methylstyrene, 5202 g potassium peroxymonosulfate and 127 g sodium iodide were added to the reactor.
2. The reaction mixture was stirred for 24 h at room temperature.
3. After this time, the reaction mixture was diluted with 85 liters of water and extracted with 30 liters DCM.
4. Water layer discarded, DCM extract was removed to afford a yellow oil.
5. Yield of phenylacetone, about 1000 g.
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