What is the actual composition?

[Frit Buchner]

Hey, I've been looking around ( yes I tried the search engine) and I am struggling to find out what these RCs actually are. I'd like to give some of them a try but there's no way I'm taking something, when I have no idea what it is.

KU crystal I recall someone saying it's a cathinone derivative it's a beta ketone?

EKU crystal, ethyl-keto amphetamine?

8clad? If it's got 8 of something it's probably an octane heptane or nonane...hmm. I don't know I couldn't come up with anything clever or funny
If you know what these or any others with cryptic bullshit names are, help a honky out.
I posted this in analytical chemistry because that's what I'm trying to do, analyze what chemicals they are. Move it, kill it, berate me, what ever you've got to do. I hope you appreciated my word salad

 

[mocnykutas]

RC chemicals was a lot form China now is shit nothing special

 

[Frit Buchner]

Right now. I think there are still magic molecules to be found but they won't be phenylethylamines, catcholamines, cathinones or tryptamines. These are wore out and there's these drug analog acts. We need to look at other drug scaffolds. I wonder what a substituted atropine could do? Harmaline looks promising, beta-carbolines haven't been explored to my knowledge

 

[41Dxflatline]

bicyclo[1.1.1]pentane replacements of phenyl rings

 

[Frit Buchner]

bicyclo[1.1.1]pentane replacements of phenyl rings

41DxflatlineThey're replacing a hexane with a pentane? What an interesting notion. Did you see my cocaphetamine drawing? But you know a hexane isn't a phenol. A cyclohexane isn't a phenol even a benzene isn't a phenol, so, just to be clear, THEY'RE SUBSTITUTING CYCLOPENTANOLS? That's wild

 

[41Dxflatline]

They're replacing a hexane with a pentane? What an interesting notion. Did you see my cocaphetamine drawing? But you know a hexane isn't a phenol. A cyclohexane isn't a phenol even a benzene isn't a phenol, so, just to be clear, THEY'RE SUBSTITUTING CYCLOPENTANOLS? That's wild

tropane"Replacement of the central, para-substituted fluorophenyl ring in the γ-secretase inhibitor 1 (BMS-708,163) withthe bicyclo[1.1.1]pentane motif led to the discovery of compound 3, an equipotent enzyme inhibitor with significant improvements in passive permeability and aqueous solubility. The modified biopharmaceutical properties of 3 translated into excellent oral absorption characteristics (∼4-fold ↑ Cmax and AUC values relative to 1) in a mouse model of γ-secretase inhibition. In addition, SAR studies into other fluorophenyl replacements indicate the intrinsic advantages of the bicyclo[1.1.1]pentane moiety over conventional phenyl ring replacements with respect to achieving an optimal balance of properties (e.g., γ-secretase inhibition, aqueous solubility/permeability, in vitro metabolic stability). Overall, this work enhances the scope of the [1.1.1]-bicycle beyond that of a mere “spacer” unit and presents a compelling case for its broader application as a phenyl group replacement in scenarios where the aromatic ring count impacts physicochemical parameters and overall drug-likeness."

They're trying this with a lot of drugs in the pharmaceutical industry lately. Don't see why Chinese RC chemists won't jump on board

 

[Frit Buchner]

I hope you guys get that I'm just fool of shit. I don't actually think I'm knowledge on the subject of chemistry. I have been studying hard, I stay up 2 nights and read patents textbooks, I try to chase down every thing I read that I don't know, and on the 3rd day I sleep for a long time. A year ago I didn't know anything useful about chemistry. I knew the names of some precursors and some reactions and now I'm struggling my ass off to calculate the enthalpy of a novel reaction that there's no information for, so... I'll stumble through it until I can do it.

 

[41Dxflatline]

There's plenty of drug receptor targets that don't rely on the classics (epinephrine, seratonin, dopamine, GABA). nAChRs and muscarinic, gabapentinoids, ghb receptor, KvLQT2, enzyme interferences.

​

 

[41Dxflatline]

Me too. Been sampling our own product have we?