What is the best chemical synthesis route of MDMA for commercial purposes in the European market?

[antrax]

Thank you all!!

 

[lalosalamanca84]

I need same information but till now i recive next info.

Best safe way is take PMK (powder or wax) CAS: 28578-16-7 and hydrolize him to make MDP2P (cas: 4676-39-5)

This way I changed pmk ethyl glycidate powder CAS 28578-16-7 to PMK oil (MDP2P; cas 4676-39-5).

pmk ethyl glycidate powder CAS 28578-16-7 1kg.
naoh 240g fermented in H2O 1400ml pour pmk ethyl glycidate CAS 28578-16-7
in NaOH+H2O reflux 80C 1h. After 1 hour, cool to room temperature.

Add 728 ml of 33% HCL to a mixture of all ingredients in a round-bottomed flask on ice. By adding all HCL reflux 80C 1h.
After 1 hour, cool to room temperature.

Separate the layer of water, keep the layer of oil at the bottom.

baking soda 200g + H2O 2000ml
Pour the oil layer into a mixture of 200 g baking soda + 2000 ml H2O.
Mix by stirring for 6-10 minutes, then stop.

Separate the layer of water, keep the layer of oil at the bottom.

Add 1 liter dcm for oil extraction in the aqueous layer.
The oil extracted by dcm from the water layer is mixed with the oil layer.
and dried with anhydrous sodium sulfate.
Evaporate DCM in a beaker.

PMK oil received (MDP2P; cas 4676-39-5) 550g pmk ethyl glycidate powder CAS 28578-16-7 1kg.

first step converting pmk to mpdp2p.....

e and naoh bicarbonate solutions will show how to make a 35% solution

1 kilo pmk well extracted from more than 500 ml mdp2p.... depends on how much more you extract with dcm

this step of converting pmk to mdp2p will have a moment where you will have to leave your bottle at 0 degrees .... you will do this with an ice bath around your glass .... in the description of the synthesis I will send you more details…

 

[CryoThio]

I’m guessing there are reports put out by the Netherlands, or someone over there, that goes into this. I’ve heard the leuckart and precious metal catalyst hydrogenations are how the rea big dogs do it

 

[Sig]

I’m guessing there are reports put out by the Netherlands, or someone over there, that goes into this. I’ve heard the leuckart and precious metal catalyst hydrogenations are how the rea big dogs do it

CryoThioWhen you want to know the Dutch way (cold version) dm me

 

[lalosalamanca84]

yes hi work with platinum...1 kg per 1 tone pmk

 

[CryoThio]

yes hi work with platinum...1 kg per 1 tone pmk

lalosalamanca84Is that platinum on carbon? What percent?

 

[FredDurst]

Is that platinum on carbon? What percent?

CryoThio

 

[FredDurst]

yes hi work with platinum...1 kg per 1 tone pmk

lalosalamanca84How big is your Hydrogenation device? Do you use a shaker or just stir?

 

[antrax]

what the hell is a catalyst in hydrogenation, I've searched for information but I still don't understand it, is it a chemical product that accelerates a chemical process?

 

[CryoThio]

what the hell is a catalyst in hydrogenation, I've searched for information but I still don't understand it, is it a chemical product that accelerates a chemical process?

antraxThat is exactly what a catalyst is. Without a metal like palladium, platinum, you aren't going to hydrogenate any PMK, make any mdma

 

[btcboss2022]

I sent a wrong answer sorry.

 

[PNicole]

Catalytic hydrogenation will be overly complicated and not something you will learn off hand or easily. I do not see how it can be all that popular of a reaction with large labs

Use NaBH4 reduction, no special equipment is needed. Most are buying things like CAS: 28578-16-7 and turning it into PMK fairly easily. You will need a vaccum distillation setup. As for the actually MDMA production, you will need Methylamine in Alcohol or Methylamine HCl. You would then find a way to mix the two in Methanol while keeping water formation low and absorbed by Silica gel or a different method. Then you simply Add the NaBH4 which is a powder to the reaction under mixing. You do it in around 8 parts making sure it stays cool. Once done, reaction is quenched with a tiny bit of acid or large amounts of water.

Your MDMA is present as an oil and you have to decide if you flood everything with water so that the methanol no longer dissolves the MDMA. You would then extract it with toluene. Or if you distill the reaction and vacuum distill the MDMA oil.

This will give you an idea of the most straight forward way .

 

[Iris He]

PMK etc raw materials supplier, this series is our main product

 

[Chemical Ali]

Personally SWiM prefers methanolic Metylamine (gassed into the MeOH) + NaBH4 from the MD-P2P on a larger scale. However, on a less huge scale, Al/Hg with Nitromethane (instead of directly using Methylamine!) is a really clean and easy way from ketone to secondary amine. Yields are very good with both methods.

Kind regards,
Ali

 

[CryoThio]

Imo, the leuckart is the best for large scale. On every official document about illegal drug production, the lecukar is always mentioned.

Easy to scale up, easy ingredients (ammonium carbonate and formic acid)

 

[Chemical Ali]

Imo, the leuckart is the best for large scale. On every official document about illegal drug production, the lecukar is always mentioned.

Easy to scale up, easy ingredients (ammonium carbonate and formic acid)

CryoThioActually for multi-kilo batches I would not choose the Leuckart reaction. Half a kilo, I see it working, but industrial scale you are probably best of with NaBH4 or LAH, followed by Al/Hg. I may be wrong but IMO NaBH4/methylamine in Methanol is probably the best route for industrial production out of the synthesises SWiM has personal experience with.

Kind regards,
Ali

 

[CryoThio]

Actually for multi-kilo batches I would not choose the Leuckart reaction. Half a kilo, I see it working, but industrial scale you are probably best of with NaBH4 or LAH, followed by Al/Hg. I may be wrong but IMO NaBH4/methylamine in Methanol is probably the best route for industrial production out of the synthesises SWiM has personal experience with.

Kind regards,
Ali

Chemical AliI'm pretty sure Dutch drug labs use the leuckart in huge multiple, multiple kilo batches. Yes it is inefficient, and low yielding, but it is simple and reagents are cheap and easy to get. Formic acid and ammonium carbonate are easy to get, and one can substitute methylamine, which they can get, so it is very popular.

This is all based on reports from the EU.

 

[Chemical Ali]

Yes it is a decent reaction, no doubt. SWiM did it with Ammonium formate a while back but I assume it was just a typo regarding the carbonate. Yields are actually pretty decent, I only think there are better ways for multikilos. I would place the Leuckart somewhere inbetween.

SWiM did some consulting abroad for a network in the regular Amphetamine buisness before, and they actually did the Al/Hg directly from P2NP on a huge scale, not ideal perhaps but it worked and the production was very fast. So I guess everything is possible with enough tweaking