Methamphetamine Synthesis from Ephedrine by Using I2 and H3PO2

[ImRegistered]

Would this synthesis work with p2p ?

 

[hacke8]

Would this synthesis work with p2p ?

ImRegisteredNo, this is only suitable for ephedrine. P2P uses amalgam or other lines.

 

[hacke8]

Other then nabh4 or tinfoil, what other methods can I look into?

ImRegisteredYes, there are many ways to choose the BB forum that suits you.

 

[caydiantak]

does this work with pseudo?

 

[hacke8]

does this work with pseudo?

caydiantakYes, this thread only applies to ephedrine and pseudoephedrine.

 

[ZMI_AA0B]

Is there any question about the distillation of anhydrous sodium sulfate after drying in Figure 16? After DCM distillation, amphetamine will be separated from DCM

 

[ZMI_AA0B]

Will the distillation of DCM methamphetamine also be carried out together with Figure 17

 

[ZMI_AA0B]

May I ask if the reason why there is no white sediment when introducing hydrogen chloride is because the extract is not dry? Or are there any other reasons that could have caused it

 

[ZMI_AA0B]

How to operate an information expert if you want to

 

[hacke8]

How to operate an information expert if you want to

ZMI_AA0BAfter the reaction is completed, add water to neutralize the acid, then adjust to alkaline PH10+ and extract it with DCM. After extraction, add sodium sulfate to dry (30 minutes to 1 hour) and filter, evaporate DCM (90-110 degrees) at normal pressure, leaving a light yellow liquid (free base of methamphetamine) and filtered after adding petroleum ether. The filtrate passes through the hydrogen chloride gas to obtain the white powder of methamphetamine hydrochloride.

 

[ZMI_AA0B]

After the reaction is completed, add water to neutralize the acid, then adjust to alkaline PH10+ and extract it with DCM. After extraction, add sodium sulfate to dry (30 minutes to 1 hour) and filter, evaporate DCM (90-110 degrees) at normal pressure, leaving a light yellow liquid (free base of methamphetamine) and filtered after adding petroleum ether. The filtrate passes through the hydrogen chloride gas to obtain the white powder of methamphetamine hydrochloride.

hacke8Teacher, what I don't understand is that if I use toluene for extraction and sodium sulfate for dry distillation, will toluene be distilled together with amphetamine

 

[ZMI_AA0B]

After the reaction is completed, add water to neutralize the acid, then adjust to alkaline PH10+ and extract it with DCM. After extraction, add sodium sulfate to dry (30 minutes to 1 hour) and filter, evaporate DCM (90-110 degrees) at normal pressure, leaving a light yellow liquid (free base of methamphetamine) and filtered after adding petroleum ether. The filtrate passes through the hydrogen chloride gas to obtain the white powder of methamphetamine hydrochloride.

hacke8Teacher, toluene is a non-polar solvent. Does that mean that after toluene is extracted, dried and filtered, hydrogen chloride can be directly introduced

 

[hacke8]

Please carefully check all reagents and all processes for errors.

 

[ZMI_AA0B]

Teacher, may I ask if the subsequent operation is the same if DCM is changed to toluene? Thank you for your guidance, teacher

 

[ZMI_AA0B]

Teacher, is it feasible to replace DCM with toluene without DCM? Is it correct to distill toluene after drying, leaving behind a yellow liquid instead of distilling it all together

 

[hacke8]

Teacher, is it feasible to replace DCM with toluene without DCM? Is it correct to distill toluene after drying, leaving behind a yellow liquid instead of distilling it all together

ZMI_AA0BYes, as long as it is a non-polar solvent. You can also put hydrogen chloride gas directly into the dried solvent without distillation.

 

[ZMI_AA0B]

Yes, as long as it is a non-polar solvent. You can also put hydrogen chloride gas directly into the dried solvent without distillation.

hacke8You are the most enthusiastic here. Only you can reply to me. If I succeed, I will definitely thank you

 

[ZMI_AA0B]

You are the most enthusiastic here. Only you can reply to me. If I succeed, I will definitely thank you

ZMI_AA0BTeacher, this is how I operate. Can you help me take a look! After heating and refluxing, I extracted it with toluene and poured it into anhydrous sodium sulfate to dry it. After filtration, I distilled the toluene and left behind amphetamine before introducing hydrogen chloride

 

[ZMI_AA0B]

May I ask which non-polar solvents can be used to extract methamphetamine

 

[hacke8]

May I ask which non-polar solvents can be used to extract methamphetamine

ZMI_AA0BYes, you can use toluene, benzene, xylene, either. They will not be distilled with the solvent because their boiling point is higher than that of the solvent. You can directly enter the hydrogen chloride gas after drying, without affecting it.

 

[ZMI_AA0B]

Yes, you can use toluene, benzene, xylene, either. They will not be distilled with the solvent because their boiling point is higher than that of the solvent. You can directly enter the hydrogen chloride gas after drying, without affecting it.

hacke8Excuse me, teacher. After heating and refluxing, first add alkaline solution with a pH value of 10 or above, and then add sodium thiosulfate before extracting with toluene. Can you teach me the next steps? Thank you

 

[ZMI_AA0B]

After the extraction is completed, keep your toluene solution, and add sodium sulfate to the solution to dry. Filter, then put hydrogen chloride gas into the solution, and the white powder is your product.

hacke8Teacher, how do those powders turn into crystals

 

[hacke8]

Teacher, how do those powders turn into crystals

ZMI_AA0BYou can use petroleum ether, it depends on your own schedule, and the powder recrystallizes into ice. You can refer to the ICE theme.

 

[ZMI_AA0B]

Is sodium sulfate drying a mixture of toluene extracted from amphetamine and sodium sulfate for sealing