Isomer seperation for Meth

[Charlie3]

Does anyone here know how to seperate between the D and L isomer for racemic meth?

 

[UWe9o12jkied91d]

Yes, there is a bunch of threads on this.Try searching for them, same methods that apply to amphetamine will work for methamphetamine.
You can use any of the 2 tartric acids, along with a host of carboxy acids.

 

[Acab1312]

Hello


From phenylisopropyl(methyl)amine freebase;

Extract the freebase amine with toluene. Prepare a solution of dextrorotary tartaric acid(1), 50g in 300ml dH2O, stir to dissolve. Extract the amine by adding in 25ml portions with vigorous shaking the acid soln. to the Toluene containing the free amine. The aqueous layer will gain a purple/red color, is separated, and placed in a separate beaker. Repeat this until no appreciable color change to the aqueous layer takes place. Pour all the aqueous extracts in an evaporating dish and let stand undisturbed for several hours until the l-amine d-tartarate crystals precipitate out of solution. Decant the mother liquor and wash the crystals with 2x25ml dH2O, adding the wash to the mother liquor. Basify the mother liquor which contains the desired d-amine d-tartarate salt. Extract w/ toluene, dry the solvent, gas w/HCl, filter the precipitate and recrystalize.

That was the easiest thing after trying a lot. As well as the most effective, for me

 

[btcboss2022]

Hello


From phenylisopropyl(methyl)amine freebase;

Extract the freebase amine with toluene. Prepare a solution of dextrorotary tartaric acid(1), 50g in 300ml dH2O, stir to dissolve. Extract the amine by adding in 25ml portions with vigorous shaking the acid soln. to the Toluene containing the free amine. The aqueous layer will gain a purple/red color, is separated, and placed in a separate beaker. Repeat this until no appreciable color change to the aqueous layer takes place. Pour all the aqueous extracts in an evaporating dish and let stand undisturbed for several hours until the l-amine d-tartarate crystals precipitate out of solution. Decant the mother liquor and wash the crystals with 2x25ml dH2O, adding the wash to the mother liquor. Basify the mother liquor which contains the desired d-amine d-tartarate salt. Extract w/ toluene, dry the solvent, gas w/HCl, filter the precipitate and recrystalize.

That was the easiest thing after trying a lot. As well as the most effective, for me

Acab1312How much freebase you use initially for that amounts? I guess around 150gr?
Thanks.

 

[Acab1312]

How much freebase you use initially for that amounts? I guess around 150gr?
Thanks.

btcboss2022Hello glad to see you again. Unfortunately, I cannot tell you how much it will be enough for. But 100g are used, but some of the h20/tataric acid remains.

 

[btcboss2022]

Hello


From phenylisopropyl(methyl)amine freebase;

Extract the freebase amine with toluene. Prepare a solution of dextrorotary tartaric acid(1), 50g in 300ml dH2O, stir to dissolve. Extract the amine by adding in 25ml portions with vigorous shaking the acid soln. to the Toluene containing the free amine. The aqueous layer will gain a purple/red color, is separated, and placed in a separate beaker. Repeat this until no appreciable color change to the aqueous layer takes place. Pour all the aqueous extracts in an evaporating dish and let stand undisturbed for several hours until the l-amine d-tartarate crystals precipitate out of solution. Decant the mother liquor and wash the crystals with 2x25ml dH2O, adding the wash to the mother liquor. Basify the mother liquor which contains the desired d-amine d-tartarate salt. Extract w/ toluene, dry the solvent, gas w/HCl, filter the precipitate and recrystalize.

That was the easiest thing after trying a lot. As well as the most effective, for me

Acab1312Method tested and works effectively, I used a similar method but this one works better thanks ;-) (I did it in larger amounts the amounts posted are for 150gr of freebase)

 

[Acab1312]

Method tested and works effectively, I used a similar method but this one works better thanks ;-) (I did it in larger amounts the amounts posted are for 150gr of freebase)

btcboss2022Hello great that it worked so well for you . Thank you now I know a bit more.

 

[Mr.Blanks00]

Hello


From phenylisopropyl(methyl)amine freebase;

Extract the freebase amine with toluene. Prepare a solution of dextrorotary tartaric acid(1), 50g in 300ml dH2O, stir to dissolve. Extract the amine by adding in 25ml portions with vigorous shaking the acid soln. to the Toluene containing the free amine. The aqueous layer will gain a purple/red color, is separated, and placed in a separate beaker. Repeat this until no appreciable color change to the aqueous layer takes place. Pour all the aqueous extracts in an evaporating dish and let stand undisturbed for several hours until the l-amine d-tartarate crystals precipitate out of solution. Decant the mother liquor and wash the crystals with 2x25ml dH2O, adding the wash to the mother liquor. Basify the mother liquor which contains the desired d-amine d-tartarate salt. Extract w/ toluene, dry the solvent, gas w/HCl, filter the precipitate and recrystalize.

That was the easiest thing after trying a lot. As well as the most effective, for me

Acab1312friend means dextromethamphetamine is in aqueous solution. have you ever tried with levotartarid acid and what is the procedure.

 

[Acab1312]

friend means dextromethamphetamine is in aqueous solution. have you ever tried with levotartarid acid and what is the procedure.

Mr.Blanks00Yes correctly the desired product is in the aqueous solution if they go according to the recipe. To avoid the problem with the distinction of wine acids (too much understand what else is meant by L or D). I always take the cheapest wine acid, which is naturally produced where.

 

[btcboss2022]

friend means dextromethamphetamine is in aqueous solution. have you ever tried with levotartarid acid and what is the procedure.

Mr.Blanks00Same process and D isomer will remain in the solid.

 

[jakespage]

Hello


From phenylisopropyl(methyl)amine freebase;

Extract the freebase amine with toluene. Prepare a solution of dextrorotary tartaric acid(1), 50g in 300ml dH2O, stir to dissolve. Extract the amine by adding in 25ml portions with vigorous shaking the acid soln. to the Toluene containing the free amine. The aqueous layer will gain a purple/red color, is separated, and placed in a separate beaker. Repeat this until no appreciable color change to the aqueous layer takes place. Pour all the aqueous extracts in an evaporating dish and let stand undisturbed for several hours until the l-amine d-tartarate crystals precipitate out of solution. Decant the mother liquor and wash the crystals with 2x25ml dH2O, adding the wash to the mother liquor. Basify the mother liquor which contains the desired d-amine d-tartarate salt. Extract w/ toluene, dry the solvent, gas w/HCl, filter the precipitate and recrystalize.

That was the easiest thing after trying a lot. As well as the most effective, for me

Acab1312Dose the separation of D & L just apply to P2P

 

[UWe9o12jkied91d]

Dose the separation of D & L just apply to P2P

jakespagephenylacetone is not chiral

 

[Acab1312]

Dose the separation of D & L just apply to P2P

jakespageUnfortunately, I do not quite understand your question. If it is related to the fact that they make their synthesis via ephedrine, the separation of the isomers is not necessary. If they start from p2p, a separation of the isomers is always necessary to form crystals, this separation is exactly related to the synthesis of p2p. I hope I could help you.

 

[jakespage]

Unfortunately, I do not quite understand your question. If it is related to the fact that they make their synthesis via ephedrine, the separation of the isomers is not necessary. If they start from p2p, a separation of the isomers is always necessary to form crystals, this separation is exactly related to the synthesis of p2p. I hope I could help you.

Acab1312How do I tell if its P2P or ephedrine synthesis ? And yes that was a big help on that last Question thank you

 

[Acab1312]

How do I tell if its P2P or ephedrine synthesis ? And yes that was a big help on that last Question thank you

jakespageI am glad that I could help them. Ephedrine and P2P are precursor products that are the main components of methamphetamine synthesis. Because precursors because they can organize the most easily, that would be their synthesis route. In large quantities, ephedrine is difficult to organize (mainly extraction from drugs) and expensive. P2P is probably the better option for most of us, despite taking extra steps to the final product. In the forum there are several syntheses for the production of P2P, as well as the conversion of BMK (cas. 5449-12-7) to P2P, and it is relatively cheap. In lists there are dealers for BMK

 

[hunter12]

Hello


From phenylisopropyl(methyl)amine freebase;

Extract the freebase amine with toluene. Prepare a solution of dextrorotary tartaric acid(1), 50g in 300ml dH2O, stir to dissolve. Extract the amine by adding in 25ml portions with vigorous shaking the acid soln. to the Toluene containing the free amine. The aqueous layer will gain a purple/red color, is separated, and placed in a separate beaker. Repeat this until no appreciable color change to the aqueous layer takes place. Pour all the aqueous extracts in an evaporating dish and let stand undisturbed for several hours until the l-amine d-tartarate crystals precipitate out of solution. Decant the mother liquor and wash the crystals with 2x25ml dH2O, adding the wash to the mother liquor. Basify the mother liquor which contains the desired d-amine d-tartarate salt. Extract w/ toluene, dry the solvent, gas w/HCl, filter the precipitate and recrystalize.

That was the easiest thing after trying a lot. As well as the most effective, for me

Acab1312Hi, why does my aqueous layer not changing colour? I used clean distilled meth freebase and added toluene, then vigorous stirring while adding mixture of H2O and l-tartaric acid

 

[hunter12]

Hello


From phenylisopropyl(methyl)amine freebase;

Extract the freebase amine with toluene. Prepare a solution of dextrorotary tartaric acid(1), 50g in 300ml dH2O, stir to dissolve. Extract the amine by adding in 25ml portions with vigorous shaking the acid soln. to the Toluene containing the free amine. The aqueous layer will gain a purple/red color, is separated, and placed in a separate beaker. Repeat this until no appreciable color change to the aqueous layer takes place. Pour all the aqueous extracts in an evaporating dish and let stand undisturbed for several hours until the l-amine d-tartarate crystals precipitate out of solution. Decant the mother liquor and wash the crystals with 2x25ml dH2O, adding the wash to the mother liquor. Basify the mother liquor which contains the desired d-amine d-tartarate salt. Extract w/ toluene, dry the solvent, gas w/HCl, filter the precipitate and recrystalize.

That was the easiest thing after trying a lot. As well as the most effective, for me

Acab1312This is what i get after heavy mixing

 

[Charlie3]

Thanks alot guys!

 

[Researcherr]

@Acab1312 could you please send me PM? Want to ask you question about Wine acid (g) / water (ml) / racemic meth oil (g) ratios for separation

 

[Frit Buchner]

It's all really more an art than a science because the optically active stereoisomer will crystalize first (D aka R with D tartaric acid, L aka S with the natural L Tartaric) but the other stereoisomer WILL eventually crystalize, so you have to remove the mother liquor at some point and the point is definitely less than the 50% that you hope is D. I'm thinking the math works out to about 28% is what you can recover in one titration.you would have to know what rour enantiomeric excess or ratio is and you would also have to weigh the crystals to actually make science of it and those are hard things to do.