p2np nabh4 amfetaminsyntese spørgsmål

[SoldadoDeDrogas]

Tuco, min ven,
Jeg kiggede på one pot synth-opskriften, og CuCl2/H2O-opløsningen er i 1/2 forhold, hvilket betyder, at for 200 mg CuCl2 ville du bruge 400 mg H2O som din opløsningsandel.
Temperaturen stiger ikke, måske fordi det er så lille en skala. Du bruger også en to-liters kolbe - det er lidt stort til det, du arbejder med, ikke?
Når CuCl2-opløsningen er tilsat, holdes temperaturen på 80 °C i 30 minutter ved hjælp af ekstern opvarmning. Har du en varmeplade, du kan bruge?
Tilsæt din NaOH-opløsning til basen. Adskil den vandige fase med IPA, og reducer den tilbage til freebase med vakuum.
Opløs freebase i acetone, og tilsæt H2SO4 til pH 6.
Placer i fryseren i ca. 12 timer.
Saml saltet, og vask det med kold, tør acetone, indtil det er hvidt.

Hvis du stadig har problemer med disse portioner, vil jeg foreslå, at du bruger et større parti. Det er en tråd på 45 sider, og det er ikke den eneste. Der må være mere information derinde, som du kan bruge. Læs, broder.

 

[TucoSalamanca.]

Lad mig fortælle dig, hvordan du gør det, først vil jeg tilføje 10 ml ipa 80 ml H2O, så vil jeg tilføje 3,5 g nabh4, så vil jeg tilføje 2 g p2np, ikke over 60 grader, så vil jeg opløse kobberchlorid 456 mg i 1 ml vand og tilføje det, ikke over 80 grader, så vil jeg opvarme det til 80 grader i 30 minutter, jeg vil tage det øverste lag og tilføje opløsningen med 16 ml vand 25% naoh, så vil jeg lave ph 6 og lægge det i fryseren.

 

[SoldadoDeDrogas]

Efter freebasering med NaOH-opløsning. Du tilsætter IPA for at opløse freebasen i vandlaget. Adskil vandlaget, og inddamp det for at få freebasen tilbage.
Tilsæt derefter freebase til acetone og tilsæt H2SO4 indtil pH 6 - derefter kan du placere den i fryseren. Der vil dannes faste stoffer, og du skal filtrere. Vask de faste stoffer med kold, tør acetone, indtil de er hvide.

 

[Chemdogkm]

Smalllllll scale. Had good success with nabh4 synth at p2np 10g scale,but yield was only 20%

 

[GhostChemist]

yield in AMP synthesis (P2NP+NaBH4) must be 60-70%
http://bbzzzsvqcrqtki6umym6itiixfhn...esis-from-p2np-with-nabh4-cucl2-1kg-scale.70/

 

[OneTensionSkyRed]

I have some interesting information on NaBH4/Cu reduction of nitropropenes. Some say that this reaction produces hydroxylamine as the main product or even as the only product. The reason is that nitropropenes are harder to reduce unlike nitrostyrenes. So NaBH4/Cu gives phenylethylamine when reducing phenyl-2-nitrostyrene but with p2np it gives N-OH instead of amine - or at least a large part of the product is N-OH with some part as amine. The problem is that amphetamine and it's hydroxylamine have very similar boiling points and melting points for their salts and they're hard to separate and analyse.
People are saying that p2np reduced by amalgam and the same p2np reduced by NaBH4/Cu have very distinct effects for users.
Can anyone confirm or debunk this? Has anyone tried analysing the product by TLC?

 

[waltjr5858]

Agreed but only the way most people run it... it will make full ampehtamine but the size and shape of the catalyst is extremely important for it to really work. Otherwise stuck with that intermediate. If the copper is just dumped into an unknown quantity of nabh4 in solution yes hydroxylamine will most likely be the product....call it almost ampehtamine. Best way is to use thf and methanol 10:1 and get the 1-phenyl-2-nitropropane intermediate with no addition reaction this way. Then destroy remaining nabh4 and isolate propane. Dissolve in the normal 2:1 isopropanol water and now we will be using a set amount of nabh4 to make proper cu nanoparticles which will absolutely reduce fully. A little finely ground carbon will also raise catalyst activity greatly. Use ratio of 1:2:0.15 for each mole of propane use 2 moles of nabh4 and 0.15 copper with about the same activated carbon. So little bits and your catalyst should start as brownish color. With the catalyst it is just increasing surface area and absorbing hydrogen and the meditates an electron transfer.... 30 mins 80c... boom fully reduced. I would practice on solvent volume to get that brown to brown red catalyst color. Without complicated equipment that's the only way I can tell the catalyst will function the way i want. I have it written down somewhere how much alcohol and water to use per gram of nabh4... that's what really matters. Don't want the copper reduced all the way immediately and inactive. I'll look.