Syntese af 2C-phenylethylaminer

[NarwhalFucker419]

Er der nogen, der har oplysninger om bromering af 2C-H med n-bromsuccinimid? Jeg har set nogle få mennesker nævne det andre steder, men jeg har ikke fundet nogen beskrivelser.

 

[Raxmil]

Jeg leder også efter dette, men jeg kunne ikke finde de detaljerede oplysninger
Hvad jeg ved er, at du kan gøre det i GAA eller DCM, men ingen idé om forholdet

 

[amieri]

There's a person in maybe theehive on Reddit.i believe the also have a mescaline synth posted too and a few others.

 

[btcboss2022]

Jeg er i tvivl om det sidste trin i 2CB-syntesen. Der står "Reaktionsblandingen fik lov til at vende tilbage til stuetemperatur, blev filtreret, og de faste stoffer blev vasket sparsomt med kold eddikesyre", indtil jeg ved, at eddikesyre bliver fast ved 16-17C, så hvad betyder kold eddikesyre nøjagtigt?
Tak skal du have.

 

[G.Patton]

Hej. Jeg går ud fra, at den kolde syre betyder stuetemperatur, fordi der er en forklaring på, at reaktionen frigiver varme.

 

[btcboss2022]

Ok ok, det tænkte jeg også, men jeg foretrak at få det bekræftet, da du ved, at når vi siger kold, mener vi normalt fra fryseren og ikke RT hahaha, men med eddikesyre er det ikke muligt ;-) tak

 

[w2x3f5]

Jeg forstår ikke helt, hvorfor man vasker aminhydrobromid, det er umuligt at bruge det, det brænder. Det er bedre at rense og få hydrochloridet, og tabene er mindre, for at undgå tvivlsomme forsøg på at vaske pulveret fra brom.

 

[nujrc]

Jeg forstår, at den resterende elementære brom vil fordampe i luften fra produktet, ligesom ethvert opløsningsmiddel, så der vil ikke være nogen rimelig mængde tilbage med tiden. Fremstilling af HCL uden tørring af HBr - held og lykke med at få et mere rent produkt, fordi du muligvis skal håndtere bromsalte i brom / GAA-opløsning og brom selv.

 

[w2x3f5]

Jeg kan ikke se nogen problemer med at slå resterne af brom med thiosulfat, derefter bringe ph til et alkalisk medium og opsamle olien med et opløsningsmiddel.

 

[situ1984]

(R)-(+)-α-methylbenzylamin CAS-nummer:
3886-69-9 Kommer det fra lungerne? Eller absorberes det af maven? Kan det bruges direkte?
(R)-(+)-α-methylbenzylamin CAS-nr:
3886-69-9 Kommer det fra lungerne? Eller optages det af maven? Kan det bruges direkte?

 

[G.Patton]

Det har ingen psykologiske effekter.

 

[amieri]

Hvor får man fat i 2,5 dimethynitrostyren?

 

[HerrHaber]

Henry-kondensation af 2,5-dimethoxybenzaldehyd med nitromethan i nærvær af en primær amin som katalysator.

 

[amieri]

It blows my mind how far I've come in this since I wrote this . You guys are all works of inspiration thanks for sharing

 

[taricshop]

Er det muligt at erstatte elementært brom med hbr-syre i 2cb-syntese?
@G.Patton

 

[Newbee]

@HEISENBERG @WillD @G.Patton
Question to you guys.Is it possible to perform bromination of 2ch to 2cb by NBS (N-Bromosuccinimide)
instead of elemental bromine (br2)

 

[G.Patton]

Hello.
Yes, I think so.

 

[amieri]

That's seems to be the new go to I see alot.i need to get some succinimide acid n give it a try.

 

[Newbee]

i found some writeups on thehivee but im not sure about it i also cant try do it on my own. but NBS seems to be safer to use than BR

 

[amieri]

I use a 2×2×4 grow tent in its side with a 8" inline fan going out the building as a hood up on a folding table definitely does the job,still wear a mask non the less. Make sure you have a 5% sodium thiosulphate solution on hand in case of a accident and a rubber made bin with enough of that solution to run through you glass at the end.and think every step out. You got this my friend can't wait to hear of your success.

 

[Swirly]

Yes, you can brominate with NBS on 2c-h HCl, you can read in my post.
You could even risk NBS bromination on 2c-h freebase in DCM or on the oxalate/sulfate salts.

Have a read:

https://bbgate.com/en-gb/threads/a-mostly-kitchen-friendly-synthesis-of-2c-b.13198/#post-73488

 

[amieri]

Sure you can, obviously dig as deep as you can researching hand but the fact you came this far says a lot.so keep pushing and if you waste something you at least gain the experience.now safety if thats what your concerned about thats a horse of a different color

 

[Rabidreject]

I just wanted to say thanks for this incredibly involved set of syntheses.
It is really impressive.
It’s funny, I made quite a few different nitrostyrene’s and nitropropene’s and then when I started reducing them and getting decent yields on active molecule’s, I started thinking okay, well it can’t be that much harder to produce the 2c-x compounds, then you see people making 2c-b and presumably other haloginated 2c’s and you think ah okay.

Then you start digging into the alkylated 2c compounds and my oh my does the chemistry take a jump in complexity!!

Anyway, I’m pretty convinced that my next major project is going to have to be the ethylated 4 position.
Is that a friedl-crafts alkylation you do to the 2,5-dimethoxyacetophenone, I mean in order to get from that to the 2,5-dimethoxy-1-ethylbenzene?

I think the most annoying part of it is that I’m going to have to get a vacuum pump that runs to super high vacuum!

Anyway, be prepared to be bugged by me a lot in the coming months/years because once I set my mind to something, I WILL learn how to get it done. It often involves harassing old posters! Ha