Question Trouble making P2NP

[chem lover]

Hello i want to make p2np for amphetamine but its hard to get nitroethane. Can i synthesis it by electrolosys of sodium propionate and potassium nitrate ? For doing henry reaction can i use other bases instead of N_butylamine like naoh ? How much will it deacrease performance?tnx

 

[Thorium-Chemist]

For the henry reaction you can also use phenethylamine, ethanolamine or amphetamine as a catalyst.
Nitroethane can be synthesized by sodium ethyl sulfate as a starting material.

 

[HIGGS BOSSON]

Nitroethane is quite difficult to synthesize, it is easier to look for a source where you can buy it. But if you are ready to dive into chemistry, then we have published several synthesis methods, the simplest in our opinion is the ethyl sulfate method. In the near future, we will publish the simplest version of the synthesis, we are already working on it.

http://bbzzzsvqcrqtki6umym6itiixfhni37ybtt7mkbjyxn2pgllzxf2qgyd.onion/en/threads/the-simplest-syntheses-of-nitroethane.573/

 

[Chemtrail]

What Higgs Boson said

You can use other based like methylamine, ethylamine, cyclohexylamine, ammonium acetate, n butylamine

Low temperature reflux 75-90C for at least 4 hours to get full conversion to p2np

 

[mewnmewamine]

You can use *any* amine as a catalyst
ethylenediamine diacetate is probably the best one (other than the beloved who we shall not name) cos ethylenediamine can be made via a hofmann rearrangment of glycinamide, which in turn can be prepared from glycine and alcoholic ammonia.
Plus it gets like over 90% yield in lit almost quantatative

Also check out doing an aldol with mek then a baeyer villiger instead in some places mek is easier found than nitroethane

You can also use a different nitroalkane such as nitromethane to get the styrene then reduce that to the ketone with something like iron in GAA.