1-Phenyl-2-nitropropene (P2NP) Video Synthesis From Benzaldehyde and Nitroethane. Henry Reaction.
- Thread starter GhostChemist
- Start date
i can only get 50% acetic acid locally, can i use this? if so, what changes would i make ( heat method ).
I know acetic acid can be a pain to get fully concentrated, is there a way to push it up to 80%?
Or can another acid be used?
Also are there any risks i should know about? (explosive/toxic fumes?)
I know acetic acid can be a pain to get fully concentrated, is there a way to push it up to 80%?
Or can another acid be used?
Also are there any risks i should know about? (explosive/toxic fumes?)
That's a shame =(
Might have to order some soon to do a test run using this method to see if it is legit ETNO2. I did read one post of someone claiming they have used it with no issue to produce P2NP so who knows. Wish I had an easy way of making it myself
Might have to order some soon to do a test run using this method to see if it is legit ETNO2. I did read one post of someone claiming they have used it with no issue to produce P2NP so who knows. Wish I had an easy way of making it myself
Just wondering could this method be scaled down in half of the original amounts along with a 5litre flask used for example ?
Ta
Ta
You can, but the results are worse, I never liked using acetate in this synthesis. Cyclohexylamine and butylamine are the best catalysts.
Hi s3v3n,
I did try this using benzaldehyde, nitroethane, and n-butylamine. As a template, I used 3,4-DMA from PIHKAL. Instead of the veratraldehyde and n-amylamine, I used benzaldehyde and n-butylamine, and adjusted the amounts accordingly.
The RM seems unchanged after a month. No solids have precipitated at all.
This was my last effort in a line of unsuccessful reactions with this nitroethane:
Nipron ®™ fuel enrichment additive cas 79-24-3 Pure nitroethane based, 100 ml.
This was supposed to be >98% nitroethane (NE). I didn't have any way to definitively check it, so it could be something other than NE or have high water content. Was expensive too - $125 for 100mL delivered.
I think this reaction (and I thought it was a Knovenagle reaction, not a Henry reaction!) would work, but there may be something about the unsubstituted benzaldehyde that requires different reaction conditions.
I did try this using benzaldehyde, nitroethane, and n-butylamine. As a template, I used 3,4-DMA from PIHKAL. Instead of the veratraldehyde and n-amylamine, I used benzaldehyde and n-butylamine, and adjusted the amounts accordingly.
The RM seems unchanged after a month. No solids have precipitated at all.
This was my last effort in a line of unsuccessful reactions with this nitroethane:
Nipron ®™ fuel enrichment additive cas 79-24-3 Pure nitroethane based, 100 ml.
This was supposed to be >98% nitroethane (NE). I didn't have any way to definitively check it, so it could be something other than NE or have high water content. Was expensive too - $125 for 100mL delivered.
I think this reaction (and I thought it was a Knovenagle reaction, not a Henry reaction!) would work, but there may be something about the unsubstituted benzaldehyde that requires different reaction conditions.
Use the proportions and conditions written in this topic, it works optimally.
Made by various routes. Butylamine and cyclohexylamine are the best catalysts for this process.
Made by various routes. Butylamine and cyclohexylamine are the best catalysts for this process.
Yes, ethylamine also works ok.
EDIT: Oh you said HCl, that will not work, you need to add alkali solution to it to obtain the freebase methylamine then use as in procedure.
EDIT: Oh you said HCl, that will not work, you need to add alkali solution to it to obtain the freebase methylamine then use as in procedure.
I'm not sure that methylamine base has enough base potency. You can try triethylamine or diethylamie.