Synthesis of 4'-methylpropiophenone from toluene by Friedel-Crafts reaction (1kg+ scale)

[CryoThio]

Are there any other Lewis acids that can be used to synthesize 4mmc from toluene?

Aluminum chloride is hard to obtain for me.

 

[AgamemnonFromTroy]

Yes, for example Iron chloride (FeCl3) and zinc chloride (ZnCl3) but the reaction will happen at a slower rate compared to using aluminium chloride.

 

[CryoThio]

The zinc and iron chlorides are anhydrous?

Which of those two give the faster reaction?

 

[AgamemnonFromTroy]

Yes they are both anhydrous and from the two iron (iii) chloride (FeCl3) would work the best

 

[AgamemnonFromTroy]

ZnCl2* not ZnCl3

 

[Germanium]

How to synthesize 3-methylpropiophenone?

 

[oneimone]

yo yo. for small synthesis the ratio of substrates are the same 3:1:1,5 or something changes?

 

[The-Hive]

Divided it by 10

 

[The-Hive]

@Frankstone

 

[TucoSalamanca.]

in this synthesis I only have a heater balloon mixer can I not use a water bath and how many degrees should not exceed when we add propinol chloride

 

[TucoSalamanca.]

This synthesis is AlCl3.6H2O, can I use this as a catalyst?

 

[CryoThio]

I'm pretty sure it has to be anhydrous aluminum chloride.

No water, whatsoever. Issue is you can't dry aluminum chloride by heating it, iirc.

Double check this though

 

[TucoSalamanca.]

20ml Propionyl Chloride
60ml toluene
34 g zinc chloride

 

[TucoSalamanca.]

I will use zinc chloride in this synthesis How many g of zinc chloride should I use in this synthesis?

 

[G.Patton]

Same molar ratio as for AlCl3

 

[TucoSalamanca.]

how many degrees should not exceed when adding propinol chloride

 

[NovicechemistEU]

**Propionyl Chloride (CH₃CH₂COCl):**

* Molar mass: 109.5 g/mol
* Number of moles: 1000 g / 109.5 g/mol ≈ 9.13 mol

Toluene (C₇H₈):** **2.

* Molar mass: 92 g/mol
* Density (25°C): ≈ 0.87 g/mL
* Mass: 3000 mL * 0.87 g/mL = 2610 g
* Number of moles: 2610 g / 92 g/mol ≈ 28.4 mol

**Aluminum Chloride (AlCl₃):**3.

* Molar mass: 133.5 g/mol
* Number of moles: 1500 g / 133.5 g/mol ≈ 11.2 mol


**Mole Ratios:**

Now, let's determine the mole ratios by proportioning the mole numbers to each other. Let's ratio according to the smallest number of moles (here propionyl chloride):

** **Propionyl Chloride : Toluene : AlCl₃**
* **9.13 mol : 28.4 mol : 11.2 mol**
* **Molar ratios - 1 : 3.11 : 1.23**

This implies a ratio of approximately 1:3:1.

 

[TucoSalamanca.]

It doesn't matter anymore, I've given up on this project.

 

[NovicechemistEU]

A simple synthesis just need to know chemistry

 

[NovicechemistEU]

Boiling points of toluene and 4'-methylpropiophenone under vacuum damper pressure.
20 mmHg.
Toluene 16.55 degrees.
4'-methylpropiophenone 123-126 degrees