¿Por qué utilizar dcm en lugar de otros disolventes?
- By waltjr5858
Dcm is awesome and boils off super low... I'll use the or hexane. Toulene... too high more heat and work
Amphetamine Synthesis From P2NP via SnCl2 and Zn
- Thread starter yuiopjkl
- Start date
¿Cuánto ácido deseado hay que añadir al final?
- By blacky2340
Vierta 10 ml de acetona en 1 ml de ácido sulfúrico concentrado al 97%+ en proporción 10:1. Utilice una pipeta o una jeringa para dejar caer la solución lentamente hasta alcanzar un pH de 5,5. Si se sobreacidifica, añadir más freebase, si se sobreacidifica mucho y se convierte en líquido entonces a a/b y recristalizar.
Hola, ¡gracias por su informe! Es realmente interesante. 10g de base libre de amf es un rendimiento del 80,4%, bastante bueno. ¿Cuánta sal obtuviste?
i just did this synthesis successfully ! (i was very astonished, that it works, like described...!)
i used 1,7g P2NP
- created sncl2 sol. from h202 and conc HCL first, until total dissolution, quenched oxidizing agent w. Bisulfite.
- dissolved p2np in acetone / EtoH and brought solutions of sncl2/p2np-solvent together in 250ml RBF
vigourously stirred for 2hrs.
------SKIPPED OXIME ISOLATION !!!!! -----
instead gave antoher dash of conc. HCL in to the whole
and gave finely divided active-C powder a hydrogen absorber in to RM.
then three portions of Zn-dust were introduced in several heaps...with subsequent hcl/EtoH addition.
as the reagents were used up i gave a small am. of AcOH to the whole and let it further react out a 15mins.
- now i slowly alkalized to ph 12 (metal precipitates formed immediate and sank...no hassle in base extraction....did with xylene/pet.ether/naphta mixture (+a small emulsion preventing splash of 2-propanol , every extraction step...)
i pooled organic xtracts, washed them with conc.brine f. rocksalt....)
afterwards the washed org.phases were run trough fine filtering apparatus.
added a 100mls of H20 and then titrated with Hcl until ph 5,5 ~
the acidic solution was equiv. mixed with acetone / ethanol-2propanol
with concentration under stirring with surface vent.
then the pasty residue was further refined...
I OBTAINED almost 1,3g amph-hcl (hygroscopic but useable!)
so that is a fine well thought route to go, THANKS TO ORIGINAL MASTERMIND
i used 1,7g P2NP
- created sncl2 sol. from h202 and conc HCL first, until total dissolution, quenched oxidizing agent w. Bisulfite.
- dissolved p2np in acetone / EtoH and brought solutions of sncl2/p2np-solvent together in 250ml RBF
vigourously stirred for 2hrs.
------SKIPPED OXIME ISOLATION !!!!! -----
instead gave antoher dash of conc. HCL in to the whole
and gave finely divided active-C powder a hydrogen absorber in to RM.
then three portions of Zn-dust were introduced in several heaps...with subsequent hcl/EtoH addition.
as the reagents were used up i gave a small am. of AcOH to the whole and let it further react out a 15mins.
- now i slowly alkalized to ph 12 (metal precipitates formed immediate and sank...no hassle in base extraction....did with xylene/pet.ether/naphta mixture (+a small emulsion preventing splash of 2-propanol , every extraction step...)
i pooled organic xtracts, washed them with conc.brine f. rocksalt....)
afterwards the washed org.phases were run trough fine filtering apparatus.
added a 100mls of H20 and then titrated with Hcl until ph 5,5 ~
the acidic solution was equiv. mixed with acetone / ethanol-2propanol
with concentration under stirring with surface vent.
then the pasty residue was further refined...
I OBTAINED almost 1,3g amph-hcl (hygroscopic but useable!)
so that is a fine well thought route to go, THANKS TO ORIGINAL MASTERMIND
* MAJOR ! update:...
I DID ONE MORE "GOD-MOVE" AFTER THIS SURPRISE RESULT:.....
I SUCCEEDED IN MODIFYING THE SYNTHESIS - AND DID A REDUCTIVE AMINATION
WITH REFINED P2P AND METHYLAMMONIUMACETATE (OR KIND OF)
IT YIELDED METHAMPHETAMINE RACEMATE.... VERY UNEXPECTED QUANTITY- QUALITY AS SAME AS THE USUAL NABH4 ROUTE I PREFERRED BEFORE...
IT WENT DOWN FROM Imine formation -[ACIDIFIED VARIANT]...... TO HYDROCHLORIDE OF SLIGHT PINK APPEARANCE OVER NIGHT !
-->AT ROOM TEMPERATURE<----
PLEASE dont be mad at me but i decided to keep specifics for myself**
it is a whole new approach to phenetylamine syntheses in general ....
CREDITS TO THIS COMMUNITY PRO INSTRUCTIONAL P2P PURIFICATION TUTORIALS / I WENT TROUGH THE HASSLE OF THE WHOLE WORKUP TECHNIQUES OF THE BB-gate wisdom ...
THE PHENYLACETONE I DERIVED BY : Fe/H+ --P2NP---> Phenyl-2-Propanone
**(exception 4 you, Patton ..i made a writeup , documenting specs etc. i think you get what these
synthesis-dynamic principles hold in value )
I DID ONE MORE "GOD-MOVE" AFTER THIS SURPRISE RESULT:.....
I SUCCEEDED IN MODIFYING THE SYNTHESIS - AND DID A REDUCTIVE AMINATION
WITH REFINED P2P AND METHYLAMMONIUMACETATE (OR KIND OF)
IT YIELDED METHAMPHETAMINE RACEMATE.... VERY UNEXPECTED QUANTITY- QUALITY AS SAME AS THE USUAL NABH4 ROUTE I PREFERRED BEFORE...
IT WENT DOWN FROM Imine formation -[ACIDIFIED VARIANT]...... TO HYDROCHLORIDE OF SLIGHT PINK APPEARANCE OVER NIGHT !
-->AT ROOM TEMPERATURE<----
PLEASE dont be mad at me but i decided to keep specifics for myself**
it is a whole new approach to phenetylamine syntheses in general ....
CREDITS TO THIS COMMUNITY PRO INSTRUCTIONAL P2P PURIFICATION TUTORIALS / I WENT TROUGH THE HASSLE OF THE WHOLE WORKUP TECHNIQUES OF THE BB-gate wisdom ...
THE PHENYLACETONE I DERIVED BY : Fe/H+ --P2NP---> Phenyl-2-Propanone
**(exception 4 you, Patton ..i made a writeup , documenting specs etc. i think you get what these
synthesis-dynamic principles hold in value )
- By binkley78
Well done tripped over a n fell into dreamland. Don't see how sharing it wld take money outta Ur pocket though. Isn't that the point of this joint to help people learn new things n say fuk U to j law n the system / war on drugs. U just fuelin the fire like the rest to line Ur own pockets n fuk every one else
No creo que esto funcione. Espero que sí y tendré que probarlo.
Espero que lo consigas, compañero, yo fracasé.
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Te escribiré, amigo mío, no dejes de rezar para que esta síntesis se haga realidad, gracias. 
Hola amigos, ¿esta reacción no produce simplemente feniletilamina (PEA) o es que soy tonto (fuerte posibilidad)
Part of this method allows you to get phenylacetone. But stage 2 can be difficult.
Hola amigo mío
He leído tu comentario y me ha gustado
¿Cómo conseguiste anfetamina pura (en el segundo paso)?
Por favor, aconséjeme qué método de producción de anfetamina es mejor y, en última instancia, tiene un mayor porcentaje de pureza
Y que obtuvo las materias primas a través de la tienda
(No tengo un laboratorio profesional)
He leído tu comentario y me ha gustado
¿Cómo conseguiste anfetamina pura (en el segundo paso)?
Por favor, aconséjeme qué método de producción de anfetamina es mejor y, en última instancia, tiene un mayor porcentaje de pureza
Y que obtuvo las materias primas a través de la tienda
(No tengo un laboratorio profesional)
Zonder de kosten van 300 gram P2NP .
alle grondstoffen voor 200 gram amfetamine free base kosten hier €416,68???
Mooi recept alleen het kan totaal niet uit
Haha good one, its one of the most otc reduction to amphetamine, and probably the best route to norephedrine analogs from the nitroalcohol 