JWH-018 synthesis

[HIGGS BOSSON]

Everything looks right!
The top layer is JWH-018 oil

 

[Gusto4205]

For the synthesis of Jwh 018 would I need a rotary evaporator or would I need distillery as well?

 

[madmoney69]

You can evaporate ethyl acetate from naphtoyl indole with warm water bath and fan

 

[Gusto4205]

Okay thank you for the clarification, I am new to this all and have everything I need on the way so trying to get all information before I start

 

[onionexpress]

you have to divide by 3 to find the amount for 1kg? Im asking cause in chemistry think works diffrent.

 

[Mora]

Everything at room temperature? And does the stering wheel need to be stainless steel?

 

[BoonDock]

Yes and everything came and was good quality.

 

[BoonDock]

Received all items and made jwh18. Customers love it!

 

[MrSung]

 

[MrSung]

Congrats and keep improving. Thumbs up

 

[charmingcho]

1-4 . The reaction mixture is quenched with ice water 20 L, extracted with ethyl acetate 15 L and filtered to remove inorganic precipitates on a nutsche filter.

Does this process use a separation funnel the water from the organic layer?

 

[G.Patton]

Yes, it takes to use separatory funnel in small scale synthesis

 

[curiousbob221]

Hi, we ordered the 109555-87-5 direct from supplier, but they sent 83-34-1.....3-methylindole.
Could this product replace the 109555-87-5 in this synthesis?
If not is there another route using the 83-34-1 or is this product no good.
Help appriechated.

 

[HerrHaber]

Sorry mate the suppliers seem to be mocking you 3-methyl indole is also known as skatole and it is the litteral smell of shit (I'm afraid I'm not joking) and unfortunately it can't be used for the preparation because the 3 position is occupied by methyl (did not say it is impossible since oxidation of the methyl to carboxylic acid which in turn could theoretically rather than in practice be converted to the acyl chloride to further Friedel-Crafts it with naphtalene is just my imagination and never heard of anyone doing this) Best advice is buy indole since it's probably the cheapest building block in the whole molecule.

 

[charmingcho]

Why doesn't the result of my experiment harden after three days? The experiment was conducted in the same way, but the purity cannot be improved by recrystallizing without hardening

 

[G.Patton]

Actually I don't know why but some people get oily product. It has same psycho activity.

 

[charmingcho]

Did you proceed the same way and get the results of the solid state?

 

[G.Patton]

I didn't. It is quite usual problem of organic synthesis. Many organic reactions give oily product, which is have to be crystalized. You have to apply some chemical tricks in order to get crystalline product. Sometimes flash chromatography is only one way. Sometimes you need just find appropriate crystallization solvent.

 

[SynthethicADHD]

Is a batch reactor essential ? I remember previously there was no batch reactor. If they are essential now how much will a 50L batch reactor set someone back.

Any info appreciated

 

[G.Patton]

You can use a reaction flask with a suitable capacity for your synthesis scale.

 

[madmoney69]

Scale down, to 20 flask