Synteza wideo 1-fenylo-2-nitropropenu (P2NP) z benzaldehydu i nitroetanu. Reakcja Henry'ego.

[HIGGS BOSSON]

Problemy z nitroetanem w Europie rozpoczęły się w 2007 roku, a następnie stopniowo wszystkie kraje wprowadzały ograniczenia dotyczące tego cennego odczynnika. Obecnie istnieją dwa sposoby: poszukiwanie dostawców w krajach o słabym prawodawstwie i rozwiniętym przemyśle chemicznym, na przykład w Bangladeszu, lub samodzielna synteza, której metodologię zaproponowaliśmy.

 

[Alojz]

Czym można zastąpić lub zsyntetyzować nitroetan?

 

[Kvadprime]

You can find methods of syntes nitroethane in another thread

 

[Kvadprime]

I have aniline as a base - what yeilds can it give?

 

[G.Patton]

Try and figure out. Share us your research data. In theory, it's quite weak base and it would be not enough to eliminate -OH group.

 

[Kvadprime]

ok, I'll definitely write how everything went... I'm still waiting for my new labware to arrive

Thx

 

[rampage]

has anyone done the microwave version of this synthesis, curious as to the outcome?

 

[William Dampier]

This is an effective method. I irradiate at maximum power in short time intervals so that the mixture does not have time to boil.

 

[rampage]

that is the key, stopping the irradiation just prior or as soon as you see 1 tiny bubble rise up, did this method with very good success, simple but very effective. would be very interested if there's other synths that can be done using the microwave??

 

[William Dampier]

Stop when strong boiling begins. Yes, this is visible by bubbles. There are many different syntheses with MW, there are also on the forum. I think that ultrasound for p2np should also work well.

 

[Chemdog010297]

Can u use trimethoxybenzaldehyde, dimethoxybenzaldehyde, or fluorobenzaldehyde for this synth ?

 

[homestead]

Why is cyclohexylamine in the video but not in the ingredient list?

 

[GhostChemist]

n-Butylamine is in the starting reagents
Cyclohexylamine is variant of catalyst

 

[homestead]

Okay so cyclohexylamine is definitely required?

 

[Idontcarethatmuch]

No it isn't. "variant" and "catalyst" should say everything. Shouldnt it?

 

[Chemtrail]

Disagree.

There are a variety (cyclohexylamine, butylamine, ammonium acetate, methylamine, etc. ) of such catalysts

With benzaldehyde and nitroethane ---> P2NP

 

[Idontcarethatmuch]

So you don't disagree with me?

 

[GhostChemist]

n-Butylamine or Cyclohexylamine or another catalyst

 

[GANG64]

I have everything, nitroethane, benzaldehyde, N-butalamine, GAA, who wana halp me for synthesis P2NP?

 

[GhostChemist]

Method of synthesis in this post and videotutorial can help you

 

[Chemdog010297]

If you have no ability to freeze precipitate the p2np, can u separate the alcohol layer and evaporate solvent or acid extract ?

 

[GhostChemist]

Evaporation is bad idea
Better is adding some portions of water

 

[Chemdog010297]

Why so ? Evaporation or acid precipitation could make this process 12 hours shorter, cost a little more, but faster. It is doable correct ? Evan to p2np oil or acidify to salt form ? Idk chemistry in that much detail, but I would assume it is somehow doable

 

[GhostChemist]

"p2np oil or acidify to salt" - p2np can't be forming the stable salts, this is nonsense (we do not consider anion salts in this case)

1. p2np decompose upon overheating
2. In the presence of base or acid, this instability is amplified: base may trigger Michael-type polycondensation, while acid can cause isomerization or hydrolysis