Separação de isômeros de metanfetamina por ácido tartárico

[Osmosis Vanderwaal]

@G.Patton Tenho alguns problemas com esse processo que espero que você possa me explicar.
Não há menção ao D-meth-D-tartate ou ao l-meth-l-tartate. Esses são os estereoisômeros opticamente ativos e não vi nenhuma evidência ou mecanismo que sugira que eles não se formem. Por serem os estereoisômeros opticamente ativos, eles se cristalizariam a uma temperatura mais alta (ou seja, mais cedo) do que os inativos. A ordem seria: D,D; L,L; D,L; L,D.
Por que NÃO seria mais econômico e eficiente usar APENAS o ácido l-tartárico, os isômeros que ocorrem naturalmente, e remover os cristais de ,l l-meth do rm antes da concentração e da cristalização?

 

[G.Patton]

Isso se deve a obstáculos espaciais. Eles não podem ser formados. Isso é descrito na literatura com outros exemplos de aminas. Pesquise se você estiver interessado.

Você pode, depende de você. O resultado será o mesmo.

 

[EveryoneHatesCris]

Okay?

 

[Osmosis Vanderwaal]

@G.Patton I find it interesting that you are reacting ammonium chloride with sulfuric acid to make your HCL gas in this write up. I've never before heard of using that method but it is viable. Is there a reason that is preffered over the more common mixtures?

 

[G.Patton]

No difference, It's up you your local reagent availability.

 

[Osmosis Vanderwaal]

I like that there is no water to gunk up the works, like there is dehydrating HCL with H2So4. I think I'll adot this method andski the drying tube

 

[G.Patton]

It's easy to get rid of water by means of CaCl2 tube filter.

 

[Osmosis Vanderwaal]

sure, or a cold trap with H2So4 inline with the output, but if I skip that I can just have a flask, a claison adaptor with a pressure equalizing drop funnel and a hose adaptor on the side arm. 4 pieces of glass, only the drop funnel being extra from a basic distillation set

 

[prvnc]

The tartaric acid method works by selectively crystallizing d-methamphetamine as the l-tartrate salt. Control pH carefully during freebase conversion and HCl gas saturation. Hot filtration and recrystallization in ethanol boost purity but reduce yield (~30% loss normal). Always verify purity with Simon’s test. Exact tartaric acid ratios and repeat crystallizations improve results.

 

[Osmosis Vanderwaal]

theres a rule that says "a good chmist is an accurate chemist" Tartaric acid doesn't "selectively crystallise" anything. that misleading Also d-meth-l tartrate mixes more than one convention of chirality, considering
d-meth=L-Meth=R=meth=legal, and
l-meth=D-meth=S-meth=illegal

 

[FlyMcgee]

Hi, wondering if someone could shed some light on a question, I have. If someone where to follow the video on how to make the Ephedrine synthesis then do the red P/I2/Ephedrine synth could they then use that mother liquor on this d-Meth synth and obtain d-Meth? (Ice)
Cheers

 

[SoldadoDeDrogas]

It would not be necessary because when you are using ephedrine or pseudo as the starting material, the result is always pure d-isomer meth after reduction. It is when we are using P2P or another material that produces a racemic product that we are able to precipitate one of the isomers for extraction, if we choose. While leaving the other in solution.