Otázka na syntézu amfetamínu p2np nabh4

[SoldadoDeDrogas]

Tu je môj priateľ,
Pozrel som si recept na syntézu v jednom hrnci a roztok CuCl2/H2O je v pomere 1/2, čo znamená, že na 200 mg CuCl2 by ste použili 400 mg H2O ako podiel vášho roztoku.
Teplota sa nezvyšuje možno preto, že je to taký malý rozsah. Taktiež používate dvojlitrovú banku - trochu veľkú na to, s čím pracujete, nie?
Po pridaní roztoku CuCl2 sa teplota udržiava na 80 C počas 30 minút pomocou vonkajšieho ohrevu. Máte horúcu platňu, ktorú môžete vytočiť?
Pridajte svoj roztok NaOH k báze. Oddeľte vodnú fázu pomocou IPA a redukujte späť na voľnú bázu pomocou vákua.
Rozpustite voľnú bázu v acetóne a pridajte H2SO4 až do pH 6.
Umiestnite do mrazničky na ~12 hodín
Zozbierajte soľ a premyte ju studeným suchým acetónom, kým nebude bielej farby.

Ak máte stále problémy s týmito dávkami, odporúčam použiť väčšiu dávku. Toto je 45-stranové vlákno a nie je jediné. Musí tam byť viac informácií, ktoré môžete použiť. Čítaj, brat.

 

[TucoSalamanca.]

Poviem vám, ako to urobiť, najprv pridám 10ml ipa 80ml h2o, potom pridám 3,5gr nabh4, potom pridám 2gr p2np, nepresahujúce 60 stupňov, potom rozpustím chlorid meďnatý 456mg v 1ml vody a pridám ho, nepresahujúce 80 stupňov, potom to zahrievam na 80 stupňov 30 minút, odoberiem vrchnú vrstvu a pridám roztok s 16ml vody 25% naoh, potom urobím ph 6 a dám to do mrazničky.

 

[SoldadoDeDrogas]

Po uvoľnení roztokom NaOH. Pridáte IPA, aby sa freebase rozpustil vo vrstve vody. Oddeľte vodnú vrstvu a odparujte, aby ste získali späť freebázu.
Potom pridáte freebázu do acetónu a pridáte H2SO4 až do pH 6 - Potom môžete umiestniť do mrazničky. Vytvoria sa tuhé látky a vy ich prefiltrujete. Tuhé látky premyte studeným suchým acetónom, kým nezískajú bielu farbu.

 

[Chemdogkm]

Smalllllll scale. Had good success with nabh4 synth at p2np 10g scale,but yield was only 20%

 

[GhostChemist]

yield in AMP synthesis (P2NP+NaBH4) must be 60-70%
http://bbzzzsvqcrqtki6umym6itiixfhn...esis-from-p2np-with-nabh4-cucl2-1kg-scale.70/

 

[OneTensionSkyRed]

I have some interesting information on NaBH4/Cu reduction of nitropropenes. Some say that this reaction produces hydroxylamine as the main product or even as the only product. The reason is that nitropropenes are harder to reduce unlike nitrostyrenes. So NaBH4/Cu gives phenylethylamine when reducing phenyl-2-nitrostyrene but with p2np it gives N-OH instead of amine - or at least a large part of the product is N-OH with some part as amine. The problem is that amphetamine and it's hydroxylamine have very similar boiling points and melting points for their salts and they're hard to separate and analyse.
People are saying that p2np reduced by amalgam and the same p2np reduced by NaBH4/Cu have very distinct effects for users.
Can anyone confirm or debunk this? Has anyone tried analysing the product by TLC?

 

[waltjr5858]

Agreed but only the way most people run it... it will make full ampehtamine but the size and shape of the catalyst is extremely important for it to really work. Otherwise stuck with that intermediate. If the copper is just dumped into an unknown quantity of nabh4 in solution yes hydroxylamine will most likely be the product....call it almost ampehtamine. Best way is to use thf and methanol 10:1 and get the 1-phenyl-2-nitropropane intermediate with no addition reaction this way. Then destroy remaining nabh4 and isolate propane. Dissolve in the normal 2:1 isopropanol water and now we will be using a set amount of nabh4 to make proper cu nanoparticles which will absolutely reduce fully. A little finely ground carbon will also raise catalyst activity greatly. Use ratio of 1:2:0.15 for each mole of propane use 2 moles of nabh4 and 0.15 copper with about the same activated carbon. So little bits and your catalyst should start as brownish color. With the catalyst it is just increasing surface area and absorbing hydrogen and the meditates an electron transfer.... 30 mins 80c... boom fully reduced. I would practice on solvent volume to get that brown to brown red catalyst color. Without complicated equipment that's the only way I can tell the catalyst will function the way i want. I have it written down somewhere how much alcohol and water to use per gram of nabh4... that's what really matters. Don't want the copper reduced all the way immediately and inactive. I'll look.