Sinteza metamfetamina iz 1- fenil -2 propanona (P2P) z reduktivno aminizacijo z natrijevim triacetoksiborohidridom (STAB)

[w2x3f5]

Diklorometan, dikloroetan se odlično obneseta, zelo olajšata delo, pridobivanje bodala iz NaBH4 se prav tako odlično obnese. Dodatne kisline ne moremo uporabiti za bodalo, reakcija je počasnejša zaradi pomanjkanja dodatne kisline, vendar je v dikloroetanu reakcija hitrejša kot v THF. Izkoristek je predvidoma nad 90 odstotkov, natančen izkoristek bo objavljen pozneje, po nekaj preverjanjih.

 

[4real]

Please can you help to break you procedure step by step? Thanks in advance

 

[ItsMee]

Ali to deluje na enak način z amoniakom ali amonijevim acetatom, da nastane amfetamin?
Potrebujem enostaven način za prehod do amfetamina iz ketona. Izopropoksid titana(IV) je ena od možnosti, vendar je drag.

 

[w2x3f5]

to morda deluje, treba je preveriti

 

[4real]

Please who knows the kind of meth one get from the reaction? D or L or DL?

 

[Speedfac]

From P2P its always racematic Meth , you have to seperate the isomers with Tartaric acid.

 

[ruen]

https://isomerdesign.com/bitnest/external/JCLIC/24.2-3.28-33

Apparently one can do the reaction, including STAB synthesis, completely in DCM, but in THF it is faster and a little cleaner
Only downside would be more nabh4 used
Ill try this soon and share my results

 

[ruen]

This method works astoundingly wery well, exactly as described in the paper. If i have time, ill share a writeup, but for now just read the paper - there is everything you need to know