1 D LSD Synthesis?

[Katty Korner]

Can anyone give a breakdown of how 1 D LSD is made?

 

[HerrHaber]

What is the 1N acyl on this one (1P, 1A, 1CP) I know. Normally the N acylation should be done on the precursor (there is a chance of acylation as a last step) so you can make all the types from the same LSD, depending on what acyl chloride is at hand. Propionyl is popular and easy to buy.

 

[HerrHaber]

What is the 1N acyl on this one (1P, 1A, 1CP) I know. Normally the N acylation should be done on the precursor (there is a chance of acylation as a last step) so you can make all the types from the same LSD, depending on what acyl chloride is at hand. Propionyl is popular and easy to buy.

HerrHaberI wonder what would be the effect if the chain is long and I have a kinky revelation right now which I wont spit here but myristoyl chloride is easy to make.

 

[HerrHaber]

What is the 1N acyl on this one (1P, 1A, 1CP) I know. Normally the N acylation should be done on the precursor (there is a chance of acylation as a last step) so you can make all the types from the same LSD, depending on what acyl chloride is at hand. Propionyl is popular and easy to buy.

HerrHaber

 

[HerrHaber]

What is the 1N acyl on this one (1P, 1A, 1CP) I know. Normally the N acylation should be done on the precursor (there is a chance of acylation as a last step) so you can make all the types from the same LSD, depending on what acyl chloride is at hand. Propionyl is popular and easy to buy.

HerrHaberAnandamide, the endogenous transmiter is an amide of arachidonic acid.

 

[LazZzZz]

Anandamide, the endogenous transmiter is an amide of arachidonic acid.

HerrHaberwhile the idea has a certin amount of stability in its idea, a few issues will first apear, the first one being the actual creation of the molecule will be a very long and inefficant process, steric hinderance and all that, the second point would be after a certain amount of carbons are added on the the amides tail, the molecule will become too non polar and not be able to diffuse through the blood brain barrier, i belive after about the 4th or 5th carbon so 1h-lsd then it becomes non psycoactive

 

[HerrHaber]

while the idea has a certin amount of stability in its idea, a few issues will first apear, the first one being the actual creation of the molecule will be a very long and inefficant process, steric hinderance and all that, the second point would be after a certain amount of carbons are added on the the amides tail, the molecule will become too non polar and not be able to diffuse through the blood brain barrier, i belive after about the 4th or 5th carbon so 1h-lsd then it becomes non psycoactive

LazZzZzI wish everyone could answer like this! are you professor? (I call people expert pretty often but professor you got a rare compliment). I honestly never thought of the entire molecular assembly is to pass the BBB, knowing it is a prodrug I could have bet it’s hydrolyzed in order to do so. Arachidonic acid goes it’s own path and LSD I’m not diving into this eternal fascinating physiology, that is how my reasoning goes and I will read. Bioconjugates are cool in their own way so it isn't shameful what I wrote knowing that dose is increased as acyl is bigger. Arachidonic acid is a frustration of mine and I hope at least one flask survived the mass destruction of my chem collection (precious because I “enforced” the DEA to give them back to me but my parents destroyed it). I will have 50g if im lucky I have an old fascination for this fat I can’t even draw the structure of (now it’s shameful for me as I present myself as a biochemist). The synthesist in me knows I won’t put into practice and yes it looks like a lot of work. Thank you for bringing light upon thid and for the stimulus of searching for more. Kindest regards!