1-Phenyl-2-nitropropene (P2NP) Video Synthesis From Benzaldehyde and Nitroethane. Henry Reaction.

[UWe9o12jkied91d]

I'm not sure that methylamine base has enough base potency. You can try triethylamine or diethylamie.

G.PattonAre you 100% sure secondary amines work? I've read they kinda do with bad yield.

 

[G.Patton]

Are you 100% sure secondary amines work? I've read they kinda do with bad yield.

UWe9o12jkied91dNo, not 100%. I know that they work well as organic base agent to start electrophilic addition reactions. And much easier and cheaper to be bought.

 

[s3v3n]

if i cant use methylamin, can i synthesise butylamin or cyclohexylamin myself or is this very difficult? thanks

 

[G.Patton]

if i cant use methylamin, can i synthesise butylamin or cyclohexylamin myself or is this very difficult? thanks

s3v3nYou can, but nobody do this. Much easy to buy.

 

[s3v3n]

Much easy to buy.

G.Pattoncan you recommend any sources, i didnt find any right away

 

[G.Patton]

can you recommend any sources, i didnt find any right away

s3v3nYou can open Listing and search around suppliers websites. I've seen something there.

 

[yin-yang]

That nitro group sucks up election density so much that you can even do this nitroaldol reaction reaction without any base catalyst. Methylamine can deprotonate nitroalkene. Ive tested works fine.

 

[G.Patton]

That nitro group sucks up election density so much that you can even do this nitroaldol reaction reaction without any base catalyst. Methylamine can deprotonate nitroalkene. Ive tested works fine.

wannabeechemistWhat the yield did you get?

 

[yin-yang]

On par with butylamine 60% but I synthesized both nitroethane and benzaldhyde myself and didn't do a proper clean up.

 

[MadHatter]

We take a glass jar with a tight lid, the main thing is that it closes tightly. Or a flask with a rubber stopper. Then load the following reagents. 110 ml of benzaldehyde 100 ml of nitroethane 17 ml N-butylamine Mix well and close tightly to prevent air from entering. Then put the jar or flask in a dark (no direct sunlight. Usually a cupboard is enough) a warm place, preferably 30-35 degrees, but it will be enough, and 25 will just last longer. We leave for 7-9 days, daily slightly shaking in circular motions. After loading the reagents, the rm will turn cloudy yellow. The next day you will see the rm turn transparent yellow. On rm 4 it will still be brighter but also have a yellowish tinge and water droplets will float above or below day 7 rm will become diluted tea, which means everything can be frozen, but if the rm has not turned amber, let the tea continue to infuse. after, after filtering and drying, we put the jar in the sea for a day, recrystallization should be carried out. The yield was 138 g after recrystallization and drying

elchapo
You put the jar in the SEA?

 

[Mo0odi]

Can anyone provide me the CAS number for cyclohexylamine?

 

[UWe9o12jkied91d]

108-91-8 @Mo0odi
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I can confirm that secondary amines don't work so well.I did 250g scale with 10ml dibutylamine.Only slight yellowing after 3h @65-70.I decided to salvage the situation by adding monoethanoloamine at which point the RM darkened significantly and went turbid.I left it refluxing for an additional 20-30 minutes at high heat and turned it off letting it cool to room temp, pured over ipa, frozen.First milking got me around 170g of P2

 

[Mo0odi]

Thank you
What do you mean by amines?

 

[UWe9o12jkied91d]

Thank you
What do you mean by amines?

Mo0odiCompounds containing an NH group, derivatives of ammonia (NH3).A few examples : Methylamine. Hexamine, Amphetamine, dibutylamine.A primary amine is is a compound that has only one of the H's in NH3 replaced by something else ex. methylamine, while secondary amines have 2 of the H's replaced by something, for example Dibutylamine, this is explained simply, there is a bit more to it but just so you understand.

The message was meant for the thread anyways, not you.We were disscusing if secondary amines can catalyze this reaction from the topic, and I indeed confirmed dibutyialmine atleast dosen't work so well.

 

[Mo0odi]

@UWe9o12jkied91d
Thanks for your explanation

 

[KDR]

Hi! What is your opinion about synthesis of benzaldehyde from styrene via ozonolysis? and Do you think is possible to sinth. bzdhd from salicylic acid or from phenol?

 

[G.Patton]

Hi! What is your opinion about synthesis of benzaldehyde from styrene via ozonolysis? and Do you think is possible to sinth. bzdhd from salicylic acid or from phenol?

KDRHello, this topic about P2NP synthesis. You can make new theme with your question.

 

[Fenster]

Anyone tried Phenethylamine as the catalyst?

 

[UWe9o12jkied91d]

Anyone tried Phenethylamine as the catalyst?

FensterI'm betting yes provided it can be freebased, if you're getting it from supplements the binders may prevent this, keep us posted, I'm curious.I was halfway to using amphtamine base as a catalyst once when I was out of propene, this would also be interesting to know.

 

[Evilcarrot2]

Hi just a quick question:
I did 100ml nitroethane
142ml benzaldehyde
And after re crystallising p2np with IPA got 149.2g after 2 days in a vacuum dessicator at full vac and 2 days air dried. Does that sound about right yied or could it be improved
Kind regards newb