1-Phenyl-2-nitropropene (P2NP) Video Synthesis From Benzaldehyde and Nitroethane. Henry Reaction.

[UWe9o12jkied91d]

Are you 100% sure secondary amines work? I've read they kinda do with bad yield.

 

[G.Patton]

No, not 100%. I know that they work well as organic base agent to start electrophilic addition reactions. And much easier and cheaper to be bought.

 

[s3v3n]

if i cant use methylamin, can i synthesise butylamin or cyclohexylamin myself or is this very difficult? thanks

 

[G.Patton]

You can, but nobody do this. Much easy to buy.

 

[s3v3n]

can you recommend any sources, i didnt find any right away

 

[G.Patton]

You can open Listing and search around suppliers websites. I've seen something there.

 

[yin-yang]

That nitro group sucks up election density so much that you can even do this nitroaldol reaction reaction without any base catalyst. Methylamine can deprotonate nitroalkene. Ive tested works fine.

 

[G.Patton]

What the yield did you get?

 

[yin-yang]

On par with butylamine 60% but I synthesized both nitroethane and benzaldhyde myself and didn't do a proper clean up.

 

[MadHatter]

You put the jar in the SEA?

 

[Mo0odi]

Can anyone provide me the CAS number for cyclohexylamine?

 

[UWe9o12jkied91d]

108-91-8 @Mo0odi
--

I can confirm that secondary amines don't work so well.I did 250g scale with 10ml dibutylamine.Only slight yellowing after 3h @65-70.I decided to salvage the situation by adding monoethanoloamine at which point the RM darkened significantly and went turbid.I left it refluxing for an additional 20-30 minutes at high heat and turned it off letting it cool to room temp, pured over ipa, frozen.First milking got me around 170g of P2

 

[Mo0odi]

Thank you
What do you mean by amines?

 

[UWe9o12jkied91d]

Compounds containing an NH group, derivatives of ammonia (NH3).A few examples : Methylamine. Hexamine, Amphetamine, dibutylamine.A primary amine is is a compound that has only one of the H's in NH3 replaced by something else ex. methylamine, while secondary amines have 2 of the H's replaced by something, for example Dibutylamine, this is explained simply, there is a bit more to it but just so you understand.

The message was meant for the thread anyways, not you.We were disscusing if secondary amines can catalyze this reaction from the topic, and I indeed confirmed dibutyialmine atleast dosen't work so well.

 

[Mo0odi]

@UWe9o12jkied91d
Thanks for your explanation

 

[KDR]

Hi! What is your opinion about synthesis of benzaldehyde from styrene via ozonolysis? and Do you think is possible to sinth. bzdhd from salicylic acid or from phenol?

 

[G.Patton]

Hello, this topic about P2NP synthesis. You can make new theme with your question.

 

[Fenster]

Anyone tried Phenethylamine as the catalyst?

 

[UWe9o12jkied91d]

I'm betting yes provided it can be freebased, if you're getting it from supplements the binders may prevent this, keep us posted, I'm curious.I was halfway to using amphtamine base as a catalyst once when I was out of propene, this would also be interesting to know.

 

[Evilcarrot2]

Hi just a quick question:
I did 100ml nitroethane
142ml benzaldehyde
And after re crystallising p2np with IPA got 149.2g after 2 days in a vacuum dessicator at full vac and 2 days air dried. Does that sound about right yied or could it be improved
Kind regards newb