4mmc freebase turns red with few acid

[Irving Langmuir]

What determines the color of 4MMC :

Yellowish - produced by ingestion of 4'-methyl-2-bromopropiophenone, making the product oily;
Yellow - Yellow-brown, brown - resins formed during overheating of the reaction mixture, iodine;
Greenish - obtained when 4'-methyl-2-bromopropiophenone gets into the final product;
Reddish, ginger, earthy colors- iodine / bromine contamination;
Blue, bluish - excess methylamine salts;
Black, dark brown pasty - n-methylpyrrolidone, DMSO, DMF.

 

[dodobird]

Most solvents used are real pain. Little research can avoid most issues.

 

[pamrz]

Is there way how to clean blue product? What are that salts? Is it save to consume?

 

[Irving Langmuir]

Recrystallization in water or IPA

 

[Bazooka90]

Which one is the color for a successful synthesis ?

 

[Irving Langmuir]

Pure mephedrone is white and odourless.

 

[dodobird]

Ph at 7 before acidification is quite low, hbr and other side reactions. For clean salt crash ph before acid usually should be above 9 or 10. Did you do Na2Co3 wash. Would be better to add Na2Co3 before acid. Depends..ea try only 125 ml to begin with. Ma40 amination hindered plus don't use acetone. Basify after amination, add very little cold dw and add hcl37 drop wise by first placing solution in ice bath. After acid 1 hr.. add ice salt slurry if needed. Cheers

 

[Irving Langmuir]

At these pH levels, you won't precipitate everything/anything. From what I've found, the pka of the amine in the mephedrone is 8, so 6.5 is a good pH for good precipitation, and the one recommended by the experts.

 

[dodobird]

What do u mean

 

[Irving Langmuir]

Acid dissociation constant - Wikipedia

en.wikipedia.org

 

[scalpere]

Why i need to basify 4MMC freebase? you mean, if my freeebase is not basic enough, i need to basify it until the pH is about 10? it cans help 4MMC freebase to give a better yield or not? I have NaOH, its the same of Na2Co3 or there are differences?

 

[Irving Langmuir]

If you have 4-MMC freebase, then it is already basic, so what do you mean? Above pH 8, you will have your freebase, below that you will form its salt (if you precipitate with HCl, you will form mephedrone hydrochloride, for example).