Acylation of Morphine Question

Katty Korner

Member
Joined
Dec 17, 2022
Messages
31
Reaction score
3
Points
8
So I've read that one can produce 6 MAM from glacial acetic acid, and catalytic amounts of sulfuric acid.

Does this work?

Also, does this work for other acids? Like propionic acid?
 

Ig0r

New member
Joined
Jan 16, 2023
Messages
5
Reaction score
5
Points
3
Hi Katty,

to answer your first question, yes it does although acetyl chloride is preferred with a Pd catalyst.
Propionic acid however requires diffrent circumstances in order to react.

Best regards
 
Joined
Sep 10, 2022
Messages
32
Reaction score
6
Points
8
I was told you could just substitute acetic anhydride with GAA and get mostly 6 MAM. Do you have any resources that show you need a catalyst for it?
 

Katty Korner

Member
Joined
Dec 17, 2022
Messages
31
Reaction score
3
Points
8
I was told you could just substitute acetic anhydride with GAA and get mostly 6 MAM. Do you have any resources that show you need a catalyst for it?
Midget_ImpingerIt's been consistently reported as needing one, but im following up with someone and it looks like it isn't necessary. Trying to sort out what is and isnt.
 
Top