Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.
- Thread starter William Dampier
- Start date
Will NMP be suitable for Pyrrolidine replacement?
I think no. Not as is, , perhaps if you can strip the methyl off of your nitrogen atom, it occupies the bond that you need to attach the velarophenone to
Ethyl acetate boils at 77c at atmospheric pressure, which suggests that yes, you can conventionally distill it ( without vacuum) but I imagine it's done under vacuum to minimize side reactions
II'm going to retract that you can even distill it without vacuum. Through out the synthesis, we are repeatedly told to keep the rm below 65c, and obviously 77c is higher than 65c
What can replace pyrrolidine then?
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
What can replace pyrrolidine then?
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
IIt makes sense .
Nothing , if you use something else, you get somethings else
1 enantiomer is not active or not very active, a common theme is drugs, since he's using D dibenzoyl tartaric acid, the D is the active isomer.
D-BENZOYL TARTARIC ACID probably only attaches to D-a-pvp. Such is the case with meth and many chiral chemicals, it is sterically hindered from attaching to the other isomer( the shape of th drugs is such that it blocks the attachment) which makes one isomers a Lewis acid salt ( dissolves in water)and the other is not propagated by the tartaric acid, so remains base, imiscible in water. that's how they are separated
Hexane is just one part of a dual solvent crystallization technique ( the other being dcm)
Nothing , if you use something else, you get somethings else
1 enantiomer is not active or not very active, a common theme is drugs, since he's using D dibenzoyl tartaric acid, the D is the active isomer.
D-BENZOYL TARTARIC ACID probably only attaches to D-a-pvp. Such is the case with meth and many chiral chemicals, it is sterically hindered from attaching to the other isomer( the shape of th drugs is such that it blocks the attachment) which makes one isomers a Lewis acid salt ( dissolves in water)and the other is not propagated by the tartaric acid, so remains base, imiscible in water. that's how they are separated
Hexane is just one part of a dual solvent crystallization technique ( the other being dcm)
I'm assuming the ethanol because both the base and the acid salt dissolve in it. ifnyou used other solvents one or the other ( base or hcl) would not dissolve, so ethanol is the preffered choice for mixed base /salt ( I'm assuming"
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What then can replace pyrrolidine... with methylamine? Or will there be another substance at the output?
- By Anarchy Labz
I wonder why basically no cathinones are ammonia based (besides the original cathinone from khat ofcourse) ? Why is 4-MMC that much more popular than 4-MC? I guess they are stronger in general but, like methcathinone is obviously stronger than cathinone but maybe some cathinones are stronger with an amino group instead of a methylamino or ethylamino group. Like some people say that MDA is stronger or better than MDMA, is there a possibility that for example the A-PVP backbone would make for a better drug if it was aminated with ammonia rather than pyrrolidine? Has anyone even tried making the popular cathinones but replaced the methyl/ethylamine/pyrrolidine without ammonia? Ammonia is very easy to get unlike methylamine. I guess some people must've tried it and were dissapointed but I've never seen anybody talk about it.
Amine=ammonia. earlier when I was looking at the result of valerophenone/ methylamine vs. valerophenone/ pyrollidine, A-pvp is way stronger than pentalone. I figure it all comes down to the QSAR. It's been studied ad nauseum in phenylethylamines, so the info is out there. I know that after 4 carbons on the chain, potency drops off (?assumable the molecule become too long for the receptor), and depending on their make- up, substituents can make mora affinity for one type of receptor or another, changing the D,N,S ratio of release. A person could collect all that data and design a drug to do basically whatever type of high you want. there are even a couple images of receptors on the internet, which one could use to design a molecule that binds incredibly tightly.
Is it really necessary use ethyl acetate in this synthesis?
Both 2-bromovalerophenone and pyrrolidine are liquid, and there is a thread in this forum to make NEP without ethyl acetate, only with 2-bromovalerophenone + ethylamine, don't use ethyl acetate would make this synthesis much safer because no risk of fire.
Both 2-bromovalerophenone and pyrrolidine are liquid, and there is a thread in this forum to make NEP without ethyl acetate, only with 2-bromovalerophenone + ethylamine, don't use ethyl acetate would make this synthesis much safer because no risk of fire.
In this case, you will most likely get local overheating upon adding pyrrolidine and resinification of the product. And at the end of the reaction, solvents will be needed for product purification anyway, for example, to remove the excess pyrrolidine. Ethylamine does not react with the same exotherm in NEP synthesis, which changes the conditions.