Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.
- Thread starter William Dampier
- Start date
Will NMP be suitable for Pyrrolidine replacement?
I think no. Not as is, , perhaps if you can strip the methyl off of your nitrogen atom, it occupies the bond that you need to attach the velarophenone to
Ethyl acetate boils at 77c at atmospheric pressure, which suggests that yes, you can conventionally distill it ( without vacuum) but I imagine it's done under vacuum to minimize side reactions
II'm going to retract that you can even distill it without vacuum. Through out the synthesis, we are repeatedly told to keep the rm below 65c, and obviously 77c is higher than 65c
What can replace pyrrolidine then?
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
What can replace pyrrolidine then?
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
What are isomers removed for?
What is ethanol for?
D benzoyl-D-tar acid?
Hexane?
They just poured everything into a pile...? Does it make sense?
Thanks in advance
IIt makes sense .
Nothing , if you use something else, you get somethings else
1 enantiomer is not active or not very active, a common theme is drugs, since he's using D dibenzoyl tartaric acid, the D is the active isomer.
D-BENZOYL TARTARIC ACID probably only attaches to D-a-pvp. Such is the case with meth and many chiral chemicals, it is sterically hindered from attaching to the other isomer( the shape of th drugs is such that it blocks the attachment) which makes one isomers a Lewis acid salt ( dissolves in water)and the other is not propagated by the tartaric acid, so remains base, imiscible in water. that's how they are separated
Hexane is just one part of a dual solvent crystallization technique ( the other being dcm)
Nothing , if you use something else, you get somethings else
1 enantiomer is not active or not very active, a common theme is drugs, since he's using D dibenzoyl tartaric acid, the D is the active isomer.
D-BENZOYL TARTARIC ACID probably only attaches to D-a-pvp. Such is the case with meth and many chiral chemicals, it is sterically hindered from attaching to the other isomer( the shape of th drugs is such that it blocks the attachment) which makes one isomers a Lewis acid salt ( dissolves in water)and the other is not propagated by the tartaric acid, so remains base, imiscible in water. that's how they are separated
Hexane is just one part of a dual solvent crystallization technique ( the other being dcm)
I'm assuming the ethanol because both the base and the acid salt dissolve in it. ifnyou used other solvents one or the other ( base or hcl) would not dissolve, so ethanol is the preffered choice for mixed base /salt ( I'm assuming"
What then can replace pyrrolidine... with methylamine? Or will there be another substance at the output?