Alpha-PVP synthesis (1-10kg scale). Complete video tutorial.

[pachemguy]

How much methylamine would one use for 1kg of bk ??

 

[OrgUnikum]

How much methylamine would one use for 1kg of bk ??

pachemguy262 g is absolute minimum, realistically 280 g - 300 g.
Thats 700 g - 750 g of a 40% MeNH2 solution in water, look at the 4-MMC synth which uses EtOAc for the workup/crystallisation as it won't work as here described for the water.

 

[pachemguy]

Thanks everyone gonna try to synth pyrrolidine direct from l-proline and copper carbonate I just have this 55gal drum of 40% laying around one day she find a good use

pachemguyCopper carbonate is not a good catalyst for this reaction copper chromate or acetophenone dose a great job I also have found success with spearmint oil and turpentine

 

[pachemguy]

Thanks everyone gonna try to synth pyrrolidine direct from l-proline and copper carbonate I just have this 55gal drum of 40% laying around one day she find a good use

pachemguyWish I could get my hands on 55gal drum you ever wanna come up off some of that lmk lol

 

[Ukspice]

@William Dampier

Need help with measurements

Instead of using :Valerophenone
I will buy liquid : 2-Bromovalerophenone

If I want to use 1litre

2-Bromovalerophenone​

What is the reagents amount I will need per I litrre:


-Hydrobromic acid (HBr) 48%;?

-Hydrogen peroxide (H2O2) 35%;?

-Pyrrolidine (CAS 123-75-1);???

-Ethyl acetate ;???

-Sodium carbonate (Na2CO3) 20% aq solution;???

-Diethyl ether (Et2O) ????

-EtOH 50 ???

-Dibenzoyl-D-tartaric acid ??

-Dichloromethane (CH2Cl2) 830 mL;

-Hexane ????

Hydrochloric acid conc. 35% (HCl);.??

WOULD REALLY HELP IF YOU CAN GET ME MEASUREMENTS FOR USE OF 1 LITRE 2-BROM. PLEASE?????

So that I can cost per reaction, also is the yield estimate about 20% loss
1 litre = 800g a-pvp?

 

[Marvin "Popcorn" Sutton]

@William Dampier

Need help with measurements

Instead of using :Valerophenone
I will buy liquid : 2-Bromovalerophenone

If I want to use 1litre

2-Bromovalerophenone​

What is the reagents amount I will need per I litrre:


-Hydrobromic acid (HBr) 48%;?

-Hydrogen peroxide (H2O2) 35%;?

-Pyrrolidine (CAS 123-75-1);???

-Ethyl acetate ;???

-Sodium carbonate (Na2CO3) 20% aq solution;???

-Diethyl ether (Et2O) ????

-EtOH 50 ???

-Dibenzoyl-D-tartaric acid ??

-Dichloromethane (CH2Cl2) 830 mL;

-Hexane ????

Hydrochloric acid conc. 35% (HCl);.??

WOULD REALLY HELP IF YOU CAN GET ME MEASUREMENTS FOR USE OF 1 LITRE 2-BROM. PLEASE?????

So that I can cost per reaction, also is the yield estimate about 20% loss
1 litre = 800g a-pvp?

UkspiceI wrote you a PM.

 

[Robertos]

I wrote you a PM.

Marvin "Popcorn" Suttonhi,i have the same question , can you ableto help?

 

[bruhh]

Is the video showing stage 4(Diastereomeric) being performed ?

 

[Poseidongo]

Can I use something else instead of valerophenone

 

[Heineken]

Can I use something else instead of valerophenone

Poseidongo2bromo valephelone can use

 

[Poseidongo]

2bromo valephelone can use

HeinekenAnything else which is available in india

 

[Heineken]

Anything else which is available in india

Poseidongoother chemicals no work to made a pvp

 

[w2x3f5]

other chemicals no work to made a pvp

HeinekenThere is the reaction of Friedel Crafts, also the Grignard reaction. you can follow these paths

 

[Poseidongo]

Is stage 4 important?

 

[Heineken]

Is stage 4 important?

Poseidongoall steps is important xD

 

[Poseidongo]

all steps is important xD

HeinekenBut in video it has shown only upto bucchner filtration that is 3rd stage

 

[Heineken]

next is made crystals like glass

 

[Poseidongo]

next is made crystals like glass

HeinekenOhh thank you so much bro. But can I stop my procedure on stage 3 as it is also producing the powder ?

 

[Heineken]

Ohh thank you so much bro. But can I stop my procedure on stage 3 as it is also producing the powder ?

Poseidongoyes but if u made crystal then u have 99% pure if u made synthesis good but this how they show on video is no good on 100%

 

[Poseidongo]

yes but if u made crystal then u have 99% pure if u made synthesis good but this how they show on video is no good on 100%

HeinekenThank you so much for guiding me brother . I think I don't have any major need to make crystal as in our country only powder substance is sold. No one buys crystals here

 

[Poseidongo]

next is made crystals like glass

HeinekenAre making those crystals important?

 

[Heineken]

Are making those crystals important?

Poseidongoof cours if u want pure product

 

[Robertos]

Hi , i have some question about STAGE 4 , any one can help ?

 

[maloo]

Does the racemic version pre stage 4 still provide a quality product? Or does stage 4 make a significant difference?