any 3CMC synthesis method?

[tajira]

Hello! can somebody provide me 3-cmc synthesis method?

 

[Bazooka90]

I would like to know also about that

 

[Selassi]

Yes im very curious too... Help would be greatly appreciated ofcourse

 

[William Dampier]

What are your starting reagents?

 

[Selassi]

Chloropropiophenone, but its the same route as with methylpropiophenone right?

 

[Selassi]

2-bromo, 3-chloropropiophenone to be exact

 

[dark_side_of_chemistry]

Chloropropiophenone, but its the same route as with methylpropiophenone right?

SelassiYes

 

[Bazooka90]

If i am right, we can use the same method like for 4mmc synthesis, replacing 2-Bromo-4-Methylpropiophenone with 2-bromo, 3-chloropropiophenone?

 

[dark_side_of_chemistry]

Exactly all bromoketones we do the same ... if we bromine a compound, then we carry out amincaje some amine. mostly using SN2 for this.

 

[Bazooka90]

Not the same ... After acidified the 3-cmc doesn't crystallize. It will be in water phase. You have to evaporate a lot of water after acidified to get Cristals.

SynthMasterHow can i do this process?

 

[William Dampier]

If i am right, we can use the same method like for 4mmc synthesis, replacing 2-Bromo-4-Methylpropiophenone with 2-bromo, 3-chloropropiophenone?

Bazooka90You just need to recalculate the proportions a little, and some features of crystallization

 

[Bazooka90]

You just need to recalculate the proportions a little, and some features of crystallization

William DampierCan you please tell which portions must be recalculated and how?

 

[Selassi]

You just need to recalculate the proportions a little, and some features of crystallization

William DampierOk ok... So cryssing is different, it will not fall out with HCl and tempreduction or how?

Couldnt find this post from SynthMaster which is quoted above

 

[William Dampier]

In general, the process is almost the same for all replaced compounds, do not worry about it. If you have reagents, write in private messages, I will help with synthesis in detail.

 

[Selassi]

You just need to recalculate the proportions a little, and some features of crystallization

William Dampier Which features do we need to change for crysallization? Does cmc crystallize with the freezermethod used in mmc-variants?

 

[William Dampier]

Which features do we need to change for crysallization? Does cmc crystallize with the freezermethod used in mmc-variants?

Selassinecessarily

 

[rafael1985]

Somebody can help with 3 cmc synthesis after acidification is still oil

 

[G.Patton]

Somebody can help with 3 cmc synthesis after acidification is still oil

rafael1985How did you do this? Can you describe your procedure?

 

[rafael1985]

How did you do this? Can you describe your procedure?

G.PattonProcedure was the same like with 4 mmc but I put I think too much 35% HCL is possible to rescue this only is

 

[G.Patton]

Procedure was the same like with 4 mmc but I put I think too much 35% HCL is possible to rescue this only is

rafael1985what pH did you reach?