• This forum actively discusses synthesis of psychoactive substances. Our forum is a research activity and does not encourage anyone to produce, distribute or use drugs! If you are less than 18 years old. then leave the forum immediately!

Bromination of 4-methylpropiophenone with CuBr2 (large scale)

William Dampier

Well-known member
Expert
Joined
Jul 19, 2021
Messages
580
Reaction score
347
Points
63
Reaction scheme:
VmX7FJ2Zlz


Synthesis:
1. Added to the flask, 1000 g 4-methylpropiophenone.
2. Poured 6000 ml of acetonitrile or ethyl acetate, and start stirring.
3. While stirring, slowly add the copper(II) bromide 1800 g.
4. Put a reflux condenser on the flask.
5. Heated under reflux for 24 hours.
6. After this time, stop heating and stirring.
7. Distilling the solvent, if needed, to obtain dry bromoketone.
8. We leave away ethyl acetate, if we plan to react in it. Theoretical yield: 1400 g.
 
Last edited by a moderator:

beetlebb

Member
Joined
Jan 7, 2022
Messages
35
Reaction score
25
Points
18
What is the obtain or actual yield on this synthesis?
 

William Dampier

Well-known member
Expert
Joined
Jul 19, 2021
Messages
580
Reaction score
347
Points
63
Approximately 1 kg of finished substance
 

ab4mp_1

New member
Joined
May 20, 2022
Messages
2
Reaction score
0
Points
1
With ethyl acetate used, this is mostly complete in 1 hour. Complete in 2 hours.
 

Morpheus77

New member
Joined
Apr 8, 2022
Messages
6
Reaction score
0
Points
1
Can this method be used with valerophenone to get a-bromovalerophenone?
 
Top