Alcohol & Xyrem/GHB
Sodium oxybate, also known as Xyrem, and gamma-hydroxybutyric acid (GHB) are both central nervous system depressants that affect the brain and body in similar ways. Both substances work by increasing the levels of a chemical called GABA in the brain through their action on two types of receptors in the brain: the GHB receptor and the GABA-B receptor.
The main chemical difference between sodium oxybate and GHB is the way in which they are structured. Sodium oxybate is a salt form of GHB and it`s generally considered to be more stable and less prone to abuse than GHB because it is more difficult to convert back into GHB in the body.
Both sodium oxybate and GHB can cause drowsiness, impaired judgment and coordination, and difficulty breathing when taken in large amounts. They can also cause withdrawal symptoms when discontinued after long-term use, including tremors, anxiety, and insomnia.
Sodium oxybate and GHB are sometimes used as a treatment for narcolepsy, a sleep disorder. They can also be used recreationally as "party drugs" due to their sedative and euphoric effects.
Alcohol is a weak agonist at the GHB receptor, which means that it can bind to the receptor and stimulate it to some extent, but not as effectively as GHB itself. Alcohol is also a weak agonist at the GABA-B receptor. In addition, alcohol can affect other neurotransmitter systems in the brain, leading to a wide range of effects on the body and mind.
It is not safe to mix alcohol and Xyrem/GHB due to the potential for serious and life-threatening side effects. All of these substances are potent central nervous system depressants, and combining them can result in heavy sedative effects, leading to an increased risk of respiratory depression, coma, and death.
These substances impair judgment and coordination, so mixing them can increase the risk of accidents and injuries.
The effects of Xyrem/GHB are unpredictable even when taken alone, and taking them with alcohol can increase the risk of overdose. Even in very small doses, the combination of alcohol and Xyrem/GHB can rapidly lead to memory loss, severe ataxia (loss of muscle control and coordination), and unconsciousness. There is a high risk of vomit aspiration (inhalation of vomit into the lungs) while unconscious.
Overall, we recommend avoiding this combination.
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