Fenethylline (Captagon) synthesis

[MadHatter]

Thank you for an excellent write-up as usual!
But I can't really see the point of the drug itself? Why ingest a prodrug that gives you a minor amount of speed and a pretty useless asthma medication? Theophylline has no psychostimulating effects I'm aware of, and I know the medicaton quite well.

 

[41Dxflatline]

Thank you for an excellent write-up as usual!
But I can't really see the point of the drug itself? Why ingest a prodrug that gives you a minor amount of speed and a pretty useless asthma medication? Theophylline has no psychostimulating effects I'm aware of, and I know the medicaton quite well.

MadHatterYou'll never been a middle eastern warlord with that attitude

 

[Mo0odi]

.yap

 

[Mo0odi]

Thank you for an excellent write-up as usual!
But I can't really see the point of the drug itself? Why ingest a prodrug that gives you a minor amount of speed and a pretty useless asthma medication? Theophylline has no psychostimulating effects I'm aware of, and I know the medicaton quite well.

MadHatterCaptagon has a very large effect and strength, like methamphetamine. It increases strength, alertness and euphoria. It is the ideal substance for warriors in the Middle East.

 

[Mo0odi]

Thank you for an excellent write-up as usual!
But I can't really see the point of the drug itself? Why ingest a prodrug that gives you a minor amount of speed and a pretty useless asthma medication? Theophylline has no psychostimulating effects I'm aware of, and I know the medicaton quite well.

MadHatterIt does not cause harm to the body like methamphetamine

Unfortunately, there is not much information about its synthesis

 

[cyb3r0]

The reaction mixture is stirred under reflux for 4 hours, filtered while hot and the precipitate dissolved in distilled water and the solution neutralized to pH 7 to give the unreacted theophylline and the synthesized symmetric 1,2-bis(7-theophyllinyl)ethane. Trituration of the taken to dryness filtrate under reduced pressure with petroleum ether or water affords the desired chloroalkyl derivative (3) in crystalline form in 99 % yield from the theoretical. The compound (3) obtained are then recrystallized from ethanol

G.PattonAnd the other point here, do you leave it here at a certain temperature?

 

[G.Patton]

And the other point here, do you leave it here at a certain temperature?

cyb3r01,2-dichloroethane boiling point (~83 deg C), read topic about Reflux please

 

[cyb3r0]

1 mol of 7-(2-Chloroethyl)theophylline (3) and 2.5 mols of 1-phenyl-2-aminopropane (4) are heated for 6 hours in an oil bath in 1 L Round-bottom flask (RBF), if necessary with addition of alcohol or toluene

G.PattonDoes water or alcohol need to be placed here for the reaction to take place for four hours, or does it react without that and does it need a condenser?

 

[G.Patton]

Does water or alcohol need to be placed here for the reaction to take place for four hours, or does it react without that and does it need a condenser?

cyb3r0You don't need to add anything else. Yes, you have to use reflex condenser.

 

[cyb3r0]

Thank you so much

 

[cyb3r0]

In the oil bath, what type of oil is used, and what is the required temperature?

 

[G.Patton]

In the oil bath, what type of oil is used, and what is the required temperature?

cyb3r0

was heated at 100 °C

Mineral oil for oil bath

 

[cyb3r0]

7-(2-Chloroethyl)theophylline (3) (0.22 mg, 0.9 mmol) and 1-phenyl-2-aminopropane (4) (0.49 g, 3.6 mmol)

G.PattonMy question here is, are the ratios correct here, the kilogram and the milligram for both substances? Thank you

 

[G.Patton]

My question here is, are the ratios correct here, the kilogram and the milligram for both substances? Thank you

cyb3r0These are grams, I fixed it. Also, you could calculate it by moles.

 

[Mo0odi]

derivative (3)

G.PattonHello
I want to know more
What is meant here by derivative (3)

 

[G.Patton]

Hello
I want to know more
What is meant here by derivative (3)

Mo0odiCan you match the number (3) with the number (3) on the reaction scheme?

 

[Mo0odi]

Hydrochloric acid (HCl) alcoholic solution;

G.PattonHello
I want your help
How do I make this solution, what is the percentage of acid in the alcohol, and what type of alcohol is used here?

 

[G.Patton]

Hello
I want your help
How do I make this solution, what is the percentage of acid in the alcohol, and what type of alcohol is used here?

Mo0odiAbout what are you talking about? EtOH.

 

[Mo0odi]

Hydrochloric acid (HCl) alcoholic solution;

G.PattonI mean, how can I make this solution, what is the method

 

[G.Patton]

I mean, how can I make this solution, what is the method

Mo0odiSorry, I don't understand your request. Reformulate it clearly please.

 

[Mo0odi]

I mean in [method 1-2] there is a hydrochloric acid (hcl) alcohol solution.

My question here is how can I make this solution

 

[41Dxflatline]

I mean in [method 1-2] there is a hydrochloric acid (hcl) alcohol solution.

My question here is how can I make this solution

Mo0odiYou literally just mix them together. I will simplify it for you, if you want a 4% solution get 100ml of your alchol and add 3.6ml of alcohol to it. assume 1% of concentration is 0.9 in 100ml and you will have no trouble.

 

[Mo0odi]

You literally just mix them together. I will simplify it for you, if you want a 4% solution get 100ml of your alchol and add 3.6ml of alcohol to it. assume 1% of concentration is 0.9 in 100ml and you will have no trouble.

41DxflatlineThank you