fentanilo sintesis desde los compuestos chinos

[chinacat]

Why do people even care about fentanyl. If we can make money putting better things into the community why don't we focus on that.

 

[Teck Tonik]

From my understanding that's not the case, I was under the impression fetty is easy to synthesize. Are you positive?

 

[Dimitry_Mendeleev]

Hedgie, I hope you don't mind, but since you were going down that road, I figure I could add one of the patents related to it's synthesis. If you feel insulted, my appologies.

The EU patent EP2252149A2 entitled A METHOD FOR THE PREPARATION OF FENTANYL. check it out, its straight forward and relatively easy to follow, plus most chemicals are easy to handle. The steps are well defined and anyone with a chemistry background can follow easily.
Here is right out from the patent:

EXAMPLE 2:

In a three neck round bottom flask equipped with mechanical stirrer and water condenser, 15.36 gm (o.lO moles) of 4-piperidone hydrochloride monohydrate and 9.3gm (0.10 moles) of aniline was added. To this mixture, 6.5 gm (O.lOmoles) of zinc and 0.6 gm (0.10 moles) of 90% acetic acid were added. The reaction mixture was stirred at room temperature for 24 hrs and at 50 to 7O0C for 24 hrs. Water was then added to the reaction mixture and filtered. Crushed ice was added to the filtrate and was neutralized with excess of aqueous sodium hydroxide solution. The crude 4- anilinopiperidine was obtained by filtration.

In two neck round bottom flask equipped with condenser 17.6 gms (0.10 moles) of 4-anilinopiperidine obtained from step 1, and 100 ml of 100% sodium hydroxide was added. The reaction mixture was heated up to 14O0C and 18.5 gms (0.1 moles) of 2-phenethyl bromide was then added. The reaction mixture was stirred for 4 hrs. After the completion of the reaction, the reaction mixture was poured in the ice cooled water. The crude product was obtained by filtration and recrystallised from petroleum ether (60 to 8O0C) to give colourless crystals of 4-anihno-N-phenethyl piperidipure fentanyl N-(l-ρhenethyl-4-piperidyl)ρropionanilide). In two neck round bottom flask equipped with condenser pressure equalizing funnel and calcium chloride guard tube, a solution of 28.0 (0.10 moles) of 4-anilino_N- phenethyl piperidme prepared in step II, in 100 ml of dichloroethane was taken. To this solution, 18.5gm (0.20 moles) of propionyl chloride was added drop wise through pressure equalizing funnel with continuous stirring. After the completion of the addition, the mixture was further stirred for 1 hrs. After the completion of the reaction, the reaction mixture was washed with 20% sodium hydroxide solution. The aqueous phase was extracted with 2x100 ml of dichloromethane. The combined organic extract was dried over sodium sulphate and concentrated to give crude fentanyl. The crude product was recrystallised from petroleum ether (60 to 8O0C) to give colourless crystals of pure fentanyl having mp 82 to 830C.

beetlebbthis information has some issue , zinc reacts with acetic acid and forms zinc acetate and then react with NaOH on neutralization to form Zinc Oxide ,and it will precipitate on neutralization not piperidone .....

 

[Dimitry_Mendeleev]

Can someone explain me is it necessary to make crude fentanyl in pure fentanyl . Is it bad if I use crude fentanyl ?

madmaximusyou can wash it with acetone 2-3 times to pure enough ..

 

[Dimitry_Mendeleev]

i need someone who can supply me with crude Fent. do anyone have any contact that want to make money?

millionmind22ask for ultra pure pharmaceutical grade fent... mail id - [email protected] , he is reliable and trustworthy i deal with him ..

 

[Dimitry_Mendeleev]

ca

From my understanding that's not the case, I was under the impression fetty is easy to synthesize. Are you positive?

Teck Tonikcant say i haven't try.