GBL synthesis

[rothschild33]

The following is a novel synthesis method for GBL.

excerpt:

In to a 100 ml round-bottomed double necked flask containing, THF (0.02 mol,
1.44g), 50% aq. hydrogen peroxide (0.06 mol, 4.08g) and Se02 ( 15mol%, 0.22g).
The reaction was continued with vigorous stirring at 35 oc for 15h. The reaction
mixture was then filtered through a Buckner funnel, passed through a short
column of silica gel to remove the catalyst and concentrated under reduced
pressure. The resulting residue was analyzed by high resolution GCMSD, El,
quadrapole mass analyzer, EM detector. The conversion of THF to GBL was
determined on the basis of the weight of the residue left after evaporation and
selectivity for GBL formation was determined by GC. Based on these analyses,
the conversion of THF was found to be 88 % with the 100 % selectivity for the
formation of GBL.

source:

An Improved Process For The Production Of Gamma Butyrolactone - Patent

The present invention relates to an improved process for the synthesis of highpurity gamma-butyrolactone by the liquid phase oxidation of tetrahydrofuranwith hydrogen peroxide as environmentally benign oxidant in the presence ofcatalytic amount of selenium (IV) oxide in the temperature range ambient

www.quickcompany.in

I have a question about this procedure. Is it possible to use a lower concentration of hydrogen peroxide such as 30% instead of 50% due to regulatory reasons while adjusting the amount of H2O2 used in the reaction?

 

[Fenster]

The yields are way low, don't waist your THF this way. Just do the GABA > NaNO2 route.

 

[rothschild33]

How is an 88% conversion of THF considered low?

 

[Fenster]

It never works out that way, besides THF is worth more then the final product. Seriously just buy kg of GABA for next to nothing.

 

[kızılkos]

It never works out that way, besides THF is worth more then the final product. Seriously just buy kg of GABA for next to nothing.

Fenstercan you explain the gaba method

 

[Billnye195]

Hey guys. I'm new to the community. Does anyone have the synthesis from BDO - GBL? If so please share. This forum is the best thing I've ever seen. Your all legends.

 

[HIGGS BOSSON]

Hey guys. I'm new to the community. Does anyone have the synthesis from BDO - GBL? If so please share. This forum is the best thing I've ever seen. Your all legends.

Billnye195

Dehydrogenation of 1,4-Butanediol (BDO) to gamma-Butyrolactone (GBL).​

A mixture of 90.1 g (1 mole) 1,4-butanediol, 4 g of copper chromite catalyst and 0.15 g of powdered reagent grade sodium hydroxide (or better KOH) was stirred vigorously and heated under reflux. At about 200 °C, a lively evolution of hydrogen occurred, and the temperature dropped about 10 °C and the dehydrogenation proceeded smoothly. The evolution of gas (39 L/2 mol per mole 1,4-butanediol reacted) ceased in about 3 h. The reaction mixture was cooled to room temperature, filtered from the catalyst and distilled under reduced pressure to give gamma-butyrolactone in about 80% yield and unreacted 1,4-butanediol in about 10% yield.

GHB (Gamma-Hydroxybutyrate) Synthesis FAQ

 

[T0lek511]

Is better and safer just buy GBL from china as cleaner

 

[BamBam]

Is better and safer just buy GBL from china as cleaner

T0lek511Have you got a link to find this cleaner in china. I’ve searched everywhere for something like this and found nothing.

 

[T0lek511]

And cheaper

 

[lucine]

The following is a novel synthesis method for GBL.

excerpt:


source:

An Improved Process For The Production Of Gamma Butyrolactone - Patent

The present invention relates to an improved process for the synthesis of highpurity gamma-butyrolactone by the liquid phase oxidation of tetrahydrofuranwith hydrogen peroxide as environmentally benign oxidant in the presence ofcatalytic amount of selenium (IV) oxide in the temperature range ambient

www.quickcompany.in

I have a question about this procedure. Is it possible to use a lower concentration of hydrogen peroxide such as 30% instead of 50% due to regulatory reasons while adjusting the amount of H2O2 used in the reaction?

rothschild33Does none of the pdfs in the link load or download for anyone else?
Can someone post the url to the main pdf document which describes the synth?

 

[evian]

check my listing guy, i sell as a cleaner company