- Jul 5, 2021
- Reaction score
Most popular amphetamine-type drugs are synthesized similarly. The main precursors benzaldehyde, which is condensed with nitroethane or nitromethane to obtain the appropriate phenyl-nitropropene (PNP) or phenyl-nitrostyrene (PNS), and then the resulting PNP or FNS is reduced to amphetamine or phenylethylamine, or the PNP is converted to phenylacetone for subsequent reduction to methamphetamine.
To synthesis substituted amphetamines, such as TMA, MDA, DOB, etc., appropriate substituted benzaldehydes are used. For example, the initial reagent for the production of MDA is 3,4 methylenedioxybenzaldehyde (piperonal).
To synthesis phenylethylamines in condensation, nitromethane is used instead of nitromethane. After the reaction, phenyl-nitrostyrene is obtained, which is reduced to obtain the necessary final substance.
For example, mescaline is prepared from 3,4,5 trimethoxybenzaldehyde, which is condensed with nitromethane to obtain the corresponding 3,4,5 trimethoxyphenyl nitrostyrene, which is then reduced to mescaline.
Methamphetamines are synthesized by reductive methylamination of phenylacetone, which can be obtained from phenyl-nitropropene, or by other available methods.
General schemes of synthesis:
a) amphetamine (phenamine) - is obtained by reducing unsupposed nitropropene, that is, in one mixing;
b) Methamphetamine (pervitin) - obtained by reductive methylamination of phenylacetone, which in turn is obtained from unsubstituted nitropropene - in two mixing;
c) Love Drug (MDA) - obtained by reducing 3,4-methylenedioxy-nitropropene - in one mixings;
d) MDMA is obtained by reducing methylamination of 3,4-methylenedioxy-phenylacetone, which in turn is obtained from 3,4-methylenedioxy-nitropropene, in two mixings;
e) MDME - obtained by reducing ethylation of 3,4-MD-phenylacetone, which, in turn, is obtained from 3,4-MD-nitropropene - for two kneadings;
f) 2,5-DMA - obtained by reducing 2,5-dimethoxy-nitropropene - in one mixing;
g) DOB - obtained by bromination of 2,5-DMA - that is, for two kneads;
h) 2C-B - obtained by bromination of 2C-H, which is obtained by reducing 2,5-dimethoxy-nitrostyrene - for two kneads;
i) 4F-A - obtained by the reduction of 4-fluoro-nitropropene - in one mixing;
j) 4F-MA is obtained by reducing methylamination of 4-fluoro-phenylacetone, which in turn is obtained from 4-fluoro-nitropropene in two mixings;
k) PMA - obtained by the reduction of 4-substituted nitropropene - in one mixing;
l) PMMA - obtained by reducing methylamination of 4-substituted phenylacetone, which, in turn, is obtained from 4-substituted nitropropene - in two kneadings;
m) TMA - obtained by reducing 3,4,5-trimethoxy-nitropropene - in one mixing;
n) TMA-2 - obtained by reducing 2,4,5-trimethoxy-nitropropene - per knead;
o) TMA-6 - obtained by reducing 2,4,6-trimethoxy-nitropropene - per knead;
p) Mescaline, obtained by reducing 3,4,5-trimethoxy-nitrostyrene, per knead.
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