GHB (Gamma-Hydroxybutyrate) Synthesis FAQ

[Rumpelstiltskin]

What is the reaction temperature of Naoh with GBL. Because boiling is not good but how do we then know that the reaction is taking place.

In other words. To which temperature should i bring and hold the Reaction Mixture ?

 

[DMTCalendar]

What is the reaction temperature of Naoh with GBL. Because boiling is not good but how do we then know that the reaction is taking place.

In other words. To which temperature should i bring and hold the Reaction Mixture ?

RumpelstiltskinLike .. I'd toss a reflux condenser on it for a while.. I've never actually burned GHB to the disgusting plastic ish stuff.. maybe 100c then wait 30m and check the PH again.. cool the sample you're ph ing to room temp.. play it by ear.. adjust heat gently.. keep a journal so you can tweak your skillz.. Always use GBL to adjust if you have it.. (I reckon).. Praise, Aunt B, smutty goddess.
much love, (some friendly envy, heh)
chemmy

 

[Katty Korner]

For the reaction of the bromobutyric acid with sodium ethoxide, can it be made any "denser"?

60 grams in 500ml of ethoxide solution is not ideal to me, if it could say be double that, or more, then I think we could be talking.

Could this be done with higher concentration of sodium ethoxide solution, to get it "denser" in terms of how much reactants and product can be made? What percentage is the original solution, as per the post?

 

[Irving Langmuir]

I'd advise anyone trying to synthesize GHB via GABA to be very careful about the excipients added to GABA (if you buy it as a dietary supplement, for example), as some make GABA insoluble in water.

 

[TheAlchemist23]

Literally my first synth back in 2006...I still remember the hyper-simplicity in doing this one step synth from the butyro-lactone to Sodium Oxibate; back then I used the "Chems-R-Us" synth route which worked wonder. After more than 300 compounds tested in 15-16y, NaGHB remains, especially when coupled with an upper (DYOR, be safe guys), one if not THE most wonderful recreational combo ever. No gabapentinoid ever provided the euphoria while producing zero hangover like this wonderfully simple endogenous carbohydrate!