JWH-018 synthesis

[WillD]

Many reagents are still legal, although the synthesis is partially hard

 

[Aaryan]

what type of equipments will i be needing ?

 

[WillD]

what type of equipments will i be needing ?

AaryanEquipments:
Flask 1L-5L-10L
Beakers 0,2-0,5-1L
Hot plates
Overhead stirrer
Pyrex(c) glass forms or silicon forms
Buchner funnel (with paper filter)
Bunsen flask 2L-5L or more
Vacuum pump (PTFE membrane)
Rotovap or ditillation falsk-complect (optionaly)

for small amounts, in detail in PM

 

[madmoney69]

For this tek rotory evaporator is a must right?
And how big volume you would recommend?

 

[sirmtr]

The real reason is that the precursors and afterbodies of the chemical formula for the synthesis of cannabinoids are also illegal, and the Chinese dare not produce chemical formulas related to it.

 

[madmoney69]

The real reason is that the precursors and afterbodies of the chemical formula for the synthesis of cannabinoids are also illegal, and the Chinese dare not produce chemical formulas related to it.

sirmtrWhich one is illegal?

 

[sirmtr]

All synthetic cannabinoid or raw material to produce the product in China are prohibited

 

[sirmtr]

At the moment it is an international crisis, no one has strong cannabidoids like in the good old days

 

[madmoney69]

For this synthesis (jwh018) all is easy to find

 

[NoidMaster]

No video, but I can advise in detail on the process here, private message or XMPP. I have enough practical experience on this synthesis.

William Dampieri need help!!

 

[Antoine14]

Hello, during syntetization, at what point does the product become illegal? is it the last step or before?

 

[WillD]

Hello, during syntetization, at what point does the product become illegal? is it the last step or before?

Antoine14Step 2

 

[jexana23]

Microwave syntetization it a not better or eazyest ?

 

[Marvin "Popcorn" Sutton]

microwave synthesis is suitable for the production of small amounts of cannabinoid, this method allows for a large yield at once

 

[LittleFlame]

Very useful, well detailed. Thanks for your work.

 

[Khun Sa]

At the moment it is an international crisis, no one has strong cannabidoids like in the good old days

sirmtrHello! In Europe you can buy three types of active and strong cannabinoids for sure:
1. SGT-78
2. ADB-BUTINACA
3. JWH-210

Last one is weak, good only for newbies. I don’t know other available noids. :/

 

[Xanderk]

Thx for sharing your knowledge, William.

 

[MrSung]

Reaction scheme:
View attachment 1235

Reagents:
Indole, cas: 120-72-9
Dichloromethane, cas: 75-09-2
Tin tetrachloride, cas: 7646-78-8
1-naphthoyl chloride, cas: 879-18-5
Nitromethane, cas: 75-52-5
Ethyl acetate, cas: 141-78-6
Sodium hydroxide, cas: 1310-73-2
TBAB, cas: 1643-19-2
1-bromopentane, cas: 110-53-2
Water


Step 1. 3-(1-naphthoyl)indole.
View attachment 1236
1. To a stirring solution of indole (1000 g) in CH2Cl2(15 liters) was added SnCl4(2000 ml) in a single portion with an ice bath cooling.
2. After the ice bath was removed, the mixture was stirred at room temperature for 30 min, and then 1-naphthoyl chloride (1627 g) was added in small portions to the suspension, followed by nitromethane (10 liters).
3. The mixture was stirred for 2 h at room temperature.
4. After being quenched with ice and water (20 liters), organic material was extracted with ethyl acetate (15 liters) and the mixture was filtered to remove inorganic precipitates.
5. The organic phase was dried over Na2SO4 and concentrated at reduced pressure to give the 3-(1-naphthoyl) indole as a crystalline solid.


Step 2. 1-pentyl-3-(1-naphthoyl)indole.
View attachment 1237
1. Weigh 2000 g of the 3-(1-naphtoyl) indole, 1300 g sodium hydroxide, 800 g TBAB and add them into 10 L flask.
2. Pour 1500 g 1-bromopentane and 3000 ml of water into the flask.
3. Mix the reaction mixture, until two different layers are separated, and the entire hydroxide is dissolved.
4. When it dissolves, the flask will be heated.
5. As soon as two layers were divided and the entire hydroxide was dissolved, put the flask on the tile, and turn the heating to the maximum.
6. Install an overhead stirrer in the flask. It is necessary to mix well enough so that the layers are homogenized.
7. The overhead stirrer can work on constant stirring the entire reaction.
8. The heating at boiling continue until the contents of the flask appear to look as much as possible (several in the "milk" color), without a clear layer dedication (usually 15-30 min passes before).
9. Then remove the flask from heating and let it be to a clear separation into two layers.
10. We need the top layer. The product can crystallize directly in the flask, which makes it difficult to extract it. Therefore, we do everything quickly.
11. Remove the top layer neatly from the flasks into the glasses, or immediately into silicone forms.
12. Leave at room temperature by 24 hours until it hardens. We take silicone forms precisely for the ease of extracting the product after crystallization, it fully solidifies and takes the form, in which it was poured.
13. We take out and crush the crystallized product. Dry on paper and trays. With a warm room and ventilation, drying usually takes two days. Yield: 3000 g.

William DampierThis is impressive and very educative, i will definitely need your guidance on my journey Mr Dampier.

 

[MrSung]

Reaction scheme:
View attachment 1235

Reagents:
Indole, cas: 120-72-9
Dichloromethane, cas: 75-09-2
Tin tetrachloride, cas: 7646-78-8
1-naphthoyl chloride, cas: 879-18-5
Nitromethane, cas: 75-52-5
Ethyl acetate, cas: 141-78-6
Sodium hydroxide, cas: 1310-73-2
TBAB, cas: 1643-19-2
1-bromopentane, cas: 110-53-2
Water


Step 1. 3-(1-naphthoyl)indole.
View attachment 1236
1. To a stirring solution of indole (1000 g) in CH2Cl2(15 liters) was added SnCl4(2000 ml) in a single portion with an ice bath cooling.
2. After the ice bath was removed, the mixture was stirred at room temperature for 30 min, and then 1-naphthoyl chloride (1627 g) was added in small portions to the suspension, followed by nitromethane (10 liters).
3. The mixture was stirred for 2 h at room temperature.
4. After being quenched with ice and water (20 liters), organic material was extracted with ethyl acetate (15 liters) and the mixture was filtered to remove inorganic precipitates.
5. The organic phase was dried over Na2SO4 and concentrated at reduced pressure to give the 3-(1-naphthoyl) indole as a crystalline solid.


Step 2. 1-pentyl-3-(1-naphthoyl)indole.
View attachment 1237
1. Weigh 2000 g of the 3-(1-naphtoyl) indole, 1300 g sodium hydroxide, 800 g TBAB and add them into 10 L flask.
2. Pour 1500 g 1-bromopentane and 3000 ml of water into the flask.
3. Mix the reaction mixture, until two different layers are separated, and the entire hydroxide is dissolved.
4. When it dissolves, the flask will be heated.
5. As soon as two layers were divided and the entire hydroxide was dissolved, put the flask on the tile, and turn the heating to the maximum.
6. Install an overhead stirrer in the flask. It is necessary to mix well enough so that the layers are homogenized.
7. The overhead stirrer can work on constant stirring the entire reaction.
8. The heating at boiling continue until the contents of the flask appear to look as much as possible (several in the "milk" color), without a clear layer dedication (usually 15-30 min passes before).
9. Then remove the flask from heating and let it be to a clear separation into two layers.
10. We need the top layer. The product can crystallize directly in the flask, which makes it difficult to extract it. Therefore, we do everything quickly.
11. Remove the top layer neatly from the flasks into the glasses, or immediately into silicone forms.
12. Leave at room temperature by 24 hours until it hardens. We take silicone forms precisely for the ease of extracting the product after crystallization, it fully solidifies and takes the form, in which it was poured.
13. We take out and crush the crystallized product. Dry on paper and trays. With a warm room and ventilation, drying usually takes two days. Yield: 3000 g.

William DampierIs this reaction very exothermic? what are some of the safety precautions that one should involve?

 

[WillD]

Is this reaction very exothermic? what are some of the safety precautions that one should involve?

MrSungWhere it is written about cooling, yes, the reaction is exothermic. Add reagents very neat and slow

 

[Khaled]

Where it is written about cooling, yes, the reaction is exothermic. Add reagents very neat and slow

William DampierWhat is an alternative to Tin (IV) chloride?