JWH-018 synthesis

[WillD]

can i connect with your project here to find support? am i here right?
I need everything from beginning. Lab supply, integreditents, knowledge.
What is the first step`? what all i have to organize before start and from where`?
please some advices i would be very thankful

abbadonContacted in PM

 

[Abusbas]

hello friend tell me please when you say :
To a stirring solution of indole (1000 g) in CH2Cl2(15 liters) you mean that i need 15 liter of CH2CI2 ?

 

[Showme61]

Hello I need help with the exact supplies required, chemicals needed and support. I want to be able to create this on my own, since its hard to come across. Also will the finished product be light in color (for example white or light yellow).

 

[Marvin "Popcorn" Sutton]

hello friend tell me please when you say :
To a stirring solution of indole (1000 g) in CH2Cl2(15 liters) you mean that i need 15 liter of CH2CI2 ?

AbusbasYep

Hello I need help with the exact supplies required, chemicals needed and support. I want to be able to create this on my own, since its hard to come across. Also will the finished product be light in color (for example white or light yellow).

I wrote to you in PM

 

[Navarroalfredo007]

Hi .Is possible to use substitute for the 1 bromopentane ,

 

[WillD]

Hi .Is possible to use substitute for the 1 bromopentane ,

Navarroalfredo007Yes. There are different replacements, but not so many powerful.

 

[David]

Hi sir
In the first part of the fifth step, what happened after adding Na2so4 and what is the crystallization, if possible, can you explain this to me?

 

[David]

In the first step, how should we get the crystal? Do we need to distill or is it possible without distillation?

 

[G.Patton]

Hi sir
In the first part of the fifth step, what happened after adding Na2so4 and what is the crystallization, if possible, can you explain this to me?

DavidAnswered in PM.

 

[G.Patton]

In the first step, how should we get the crystal? Do we need to distill or is it possible without distillation?

DavidThe organic phase was dried over Na2SO4 and concentrated at reduced pressure to give the 3-(1-naphthoyl) indole as a crystalline solid.
You have to use Rotary evaporator and additional equipment
Learn Laboratory FAQ

 

[Selassi]

Hello!
I made little of jwh-018 by your method, but it's very dark, like cocoa.
How i can clean it? I tried to recrystallize it from hot methanol.
With little water (~90% methanol by specific gravity) it precipitates more readily, but still looks bad.
You can use perchloroethylene instead of dcm and nitromethane.

I'm not sure about my naphtoyl chloride, i get it old from lab. But it melts right.

Also i was intoxicated little bit by touching it before it dried, it was hard hours.
Anyone made cb1 antagonists?

(forgot my username)

Hip-Hop-GruppeYes its very dark here too, like dark chocolate. So i guess its normal with this naphtoyl-indole, which also has this darker brown color. In contrary to the tmpc-indole in the photos.

 

[Selassi]

Its hardening as we speak so ill keep u all updated

 

[WillD]

Without experience, it is better to use ready-made 3-(1-naphthoyl)indole, under one reaction. But soon there will be a video of the full synthesis, it will become easier with questions.

 

[BoonDock]

I see many people asking for this info. I did this researching myself. It took a few days but with a few emails and google researching this is what i have found.
All you need to do is a little research to get these prices. Still having a real hard time finding Nitromethane but im looking.

Product	CAS#	Vendor	Cost	Makes	Usage Per KG	Cost per KG
Indole	120-72-9	Alibaba	10kg $535	29	334g	$18
DMC	75-09-2	USA	55G $500	41	5 Liters	$12
Tin tetrachloride	7646-78-8	Alibaba	5kg $345	16	665 ml	$21
1-naphthoyl chloride	879-18-5	Alibaba	5kg $1075	9	545g	$118
Nitromethane	75-52-5				3.5 Liters
Ethyl acetate	141-78-6	USA	5gal $280	3	5 Liters	$15
Sodium hydroxide	1310-73-2	USA	22kg $117	50	435g	$3
TBAB	1643-19-2	Alibaba	5kg $108	18	270g	$6
1-bromopentane	110-53-2	Alibaba	5kg $246	10	500g	$25

 

[Selassi]

Great work bro, a little research comes a long way...

 

[madmoney69]

Nitromethane is sold by advertised seller on this site, pls check

 

[orgasmatron]

Yes. There are different replacements, but not so many powerful.

William Dampier

I see many people asking for this info. I did this researching myself. It took a few days but with a few emails and google researching this is what i have found.
All you need to do is a little research to get these prices. Still having a real hard time finding Nitromethane but im looking.

Product	CAS#	Vendor	Cost	Makes	Usage Per KG	Cost per KG
Indole	120-72-9	Alibaba	10kg $535	29	334g	$18
DMC	75-09-2	USA	55G $500	41	5 Liters	$12
Tin tetrachloride	7646-78-8	Alibaba	5kg $345	16	665 ml	$21
1-naphthoyl chloride	879-18-5	Alibaba	5kg $1075	9	545g	$118
Nitromethane	75-52-5				3.5 Liters
Ethyl acetate	141-78-6	USA	5gal $280	3	5 Liters	$15
Sodium hydroxide	1310-73-2	USA	22kg $117	50	435g	$3
TBAB	1643-19-2	Alibaba	5kg $108	18	270g	$6
1-bromopentane	110-53-2	Alibaba	5kg $246	10	500g	$25

wait.... is this cors per kg, cost for the fraction used per kg of final product or cost per kg of each component? usage per kg is a bit shady to me as well, for example, DCM 12 USD together with 18USD indole does not match what I see.

 

[BoonDock]

wait.... is this cors per kg, cost for the fraction used per kg of final product or cost per kg of each component? usage per kg is a bit shady to me as well, for example, DCM 12 USD together with 18USD indole does not match what I see.

orgasmatronIts my chart i use. Its the cost to make 1kg and how much is used to make it. Example Indole, i buy 10kg for 535$. Based on the synthesis outlined in this thread it takes 1000g to make 3kg. I just make it in 1kg measurements and just broke it down. Indole to make 1kg would be 334g. same goes for each item. I could just multiply each by 3 to make the threads recipe.

 

[khundongdong]

is JWH-018 the easiest to synthesis amongst all the cannaniboids?

 

[BoonDock]

is JWH-018 the easiest to synthesis amongst all the cannaniboids?

khundongdongIMO 2nd, first is ur-144