N-BUTYLAMINE Synthesis

[senseiFreu]

Hi guys, I managed to write the synthesis of n-butylamine to ChatGPT somehow, but I don't have much knowledge about chemistry and I have a few questions:
1- Does it really work?
2- Is the size of the balloon important that I used for the reaction?

here is the synthesis:

C) Synthesis of n-butylamine

CHEMICALS: Materials needed:

• 4.4 g sodium hydroxide (NaOH)
• 8.2 g sodium chloride (NaCl)
• 8.5 mL n-butanol (CH3(CH2)3OH)
• 50 mL distilled water (H2O)
• 100 mL flat-bottomed flask (250 mL)
• 100 mL round-bottomed flask (250 mL)
• Cooling bath (pre-cooled in the fridge)
• Water bath (set to 60-70 °C)

Preparation:
1- Add 4.4 g NaOH and 8.2 g NaCl to the flat-bottomed flask.
2- Add 50 mL distilled water and stir.
3- Fill the flask with 100 mL n-butanol and stir well.
4- Place the round-bottomed flask in the cooling bath.
5- Pour the NaOH/NaCl/water mixture into the round-bottomed flask.
6- Add the n-butanol from the flat-bottomed flask to the round-bottomed flask.
7- Heat slowly in the water bath and stir.
8- Continue heating and stirring for 1 hour.
9- Remove the round-bottomed flask from the cooling bath and let it cool to room temperature.
10- Carefully remove the upper layer and discard the bottom liquid layer.
11- Transfer the upper layer to the flat-bottomed flask and stir well.
12- To obtain pure n-butylamine, use a distillation apparatus to separate the mixture in the flat-bottomed flask into pure n-butylamine.

The distillation in step 12 can be carried out using the following steps:

1- Transfer the reaction mixture to a glass distillation column. Place a small amount of glass wool at the bottom of the column.
2- Place a heating source under the column and connect the column to a water-cooled condenser.
3- Begin heating the reaction mixture, and when the liquid begins to vaporize, lower the temperature of the heating source under the column to slow down the reaction.
4- The vaporized liquid will condense on the glass wool in the column and drip down back to the heating source under the column.
5- At the point where n-butylamine gas is formed, a higher temperature is required. Therefore, increase the temperature of the heating source under the column to allow the n-butylamine gas to condense at this point.
6- The condensed n-butylamine gas will be cooled by the condenser and turn back into liquid form.
7- The liquid n-butylamine will drip into a collection flask placed under the condenser.
8- Once the distillation process is complete, the n-butylamine should be collected from the collection flask and stored in another container.

 

[Joker_55555]

Hi guys, I managed to write the synthesis of n-butylamine to ChatGPT somehow, but I don't have much knowledge about chemistry and I have a few questions:
1- Does it really work?
2- Is the size of the balloon important that I used for the reaction?

here is the synthesis:

C) Synthesis of n-butylamine

CHEMICALS: Materials needed:

• 4.4 g sodium hydroxide (NaOH)
• 8.2 g sodium chloride (NaCl)
• 8.5 mL n-butanol (CH3(CH2)3OH)
• 50 mL distilled water (H2O)
• 100 mL flat-bottomed flask (250 mL)
• 100 mL round-bottomed flask (250 mL)
• Cooling bath (pre-cooled in the fridge)
• Water bath (set to 60-70 °C)

Preparation:
1- Add 4.4 g NaOH and 8.2 g NaCl to the flat-bottomed flask.
2- Add 50 mL distilled water and stir.
3- Fill the flask with 100 mL n-butanol and stir well.
4- Place the round-bottomed flask in the cooling bath.
5- Pour the NaOH/NaCl/water mixture into the round-bottomed flask.
6- Add the n-butanol from the flat-bottomed flask to the round-bottomed flask.
7- Heat slowly in the water bath and stir.
8- Continue heating and stirring for 1 hour.
9- Remove the round-bottomed flask from the cooling bath and let it cool to room temperature.
10- Carefully remove the upper layer and discard the bottom liquid layer.
11- Transfer the upper layer to the flat-bottomed flask and stir well.
12- To obtain pure n-butylamine, use a distillation apparatus to separate the mixture in the flat-bottomed flask into pure n-butylamine.

The distillation in step 12 can be carried out using the following steps:

1- Transfer the reaction mixture to a glass distillation column. Place a small amount of glass wool at the bottom of the column.
2- Place a heating source under the column and connect the column to a water-cooled condenser.
3- Begin heating the reaction mixture, and when the liquid begins to vaporize, lower the temperature of the heating source under the column to slow down the reaction.
4- The vaporized liquid will condense on the glass wool in the column and drip down back to the heating source under the column.
5- At the point where n-butylamine gas is formed, a higher temperature is required. Therefore, increase the temperature of the heating source under the column to allow the n-butylamine gas to condense at this point.
6- The condensed n-butylamine gas will be cooled by the condenser and turn back into liquid form.
7- The liquid n-butylamine will drip into a collection flask placed under the condenser.
8- Once the distillation process is complete, the n-butylamine should be collected from the collection flask and stored in another container.

senseiFreuIncomplete or wrong

 

[UWe9o12jkied91d]

Your best bet for a primary amine is to buy or if you are hell bent to make it you can sunthesize methylamine hcl by refluxing hexamine with HCl

 

[senseiFreu]

thanks both

 

[PNicole]

Wow I can only imagine the horror of synthesizing that compound. Just opening and pouring from the reagent grade bottle was a trip.

 

[wael gano]

Wow I can only imagine the horror of synthesizing that compound. Just opening and pouring from the reagent grade bottle was a trip.

PNicoleIt may smell like ammonia

 

[BlueDex]

You oxidize N-Butanol with PCC, then use the butyraldehyde and mix it with ammonia solution in water and ethanol to make the imine, then reduce it with non-toxic Aluminum Galinstan amalgam to make N-Butylamine.

 

[BlueDex]

You oxidize N-Butanol with PCC, then use the butyraldehyde and mix it with ammonia solution in water and ethanol to make the imine, then reduce it with non-toxic Aluminum Galinstan amalgam to make N-Butylamine.

BlueDexAdding Palladium on Carbon catalyst and Carbonic acid (Seltzer Water) and Formic acid and Potassium Formate and pH 5 and 20°C to 30° C for a few hours boosts the yield. Carbonic acid breaks down into Hydrogen oxide (H2O, Water) and Carbon Dioxide (CO2). The CO2 provides an inert atmosphere, and you can also flush out the flask with Argon or Nitrogen. Palladium on Carbon boost yield.

 

[xoxo2.0]

Have a look...